DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and Usp2

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	128/592 - (21%)
Similarity:	218/592 - (36%)	Gaps:	165/592 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GGNSSAGSSTDQAKSGEDTNGSLQNHIVANAKRILMAKIEYEEVPN--YHESVLENLKSKYIVIK 85
            ||..|..|.::.......::.:||....::...|.:|......:..  |..:...|..|..:.:.
  Fly   386 GGRLSVASRSNHGSQAGGSSSNLQQRYSSDLDNIRVAAGYSSSLTRAAYRTTATMNSVSTPVAVT 450

  Fly    86 PGNPGAINGFSGK------NNTGKLVGANGHDN------------NGARKQ-------------A 119
            ....|.|:|..|:      ..|.|:.....|.|            |.|.|.             |
  Fly   451 SELGGPISGDGGETATAMGQPTSKVTVRGAHSNRQPIECDSVVLTNKASKDATTAATPTVATATA 515

  Fly   120 EH----------------PNNQSHHINHHNHQHPTSN------PNELPKPKRVLYPRENIRIGWK 162
            .|                ||:.|..::....:.|.|:      .......:.||.|..      .
  Fly   516 THTPATSSVSTVTVTAAAPNSASDSVSRSLARSPISSTLARSGTGSSSTARSVLPPMT------P 574

  Fly   163 QSERKW---------QVGT--------------------------------GMINVGNTCYLNST 186
            .|.|.|         .:||                                |:.|:||||::||.
  Fly   575 TSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSDDGYKTASSSRDEKSEGLCGLRNIGNTCFMNSV 639

  Fly   187 LQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAMTKTLLAT-QSNQSAVRPFLIYSKLKQI 250
            :|.|.|...|..:|   ::|....:::..... |:....|.:... .:|...|.|.    :||:.
  Fly   640 IQCLSHTQELTRFL---RSHHGSRSLSTKDQQ-ILHEFAKLIQEMWTANVHTVTPM----ELKRA 696

  Fly   251 --CKHMVVG--RQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVK------------------- 292
              .||.:..  .|:||.|||||.::::..|          |:..||
  Fly   697 FSTKHRMYSDYNQQDAQEFLRFFLDSLHSA----------LNSGVKGETLNIDDNLSDNKKADLT 751

  Fly   293 -------ETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKAD--SLEDAFEGHFSRE 348
                   |.:.:..:|.|.|:|.::|.:|.:.|:||..|.||.:.:..:.  .||...:.....|
  Fly   752 WEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSSRCKLEACLDLFIREE 816

  Fly   349 RLE-DMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMI-GNKLTKQISF---KSRIDLSKY 408
            .|: |....|..||.:...||.|:::|.|..|.|.|||||.. .:||:..:.|   .|.:::..|
  Fly   817 VLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFSETRWSKLSNIVEFPTSDSELNMGSY 881

  Fly   409 AARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTG-SFYNFDDSYVR-PIAMHSVCNTN 471
            .|.|.:    .:.|.|.::..|:|::.. |||.|:...... .::.|:|:.|. .::.:.:.:::
  Fly   882 GANSNS----NVHYSLYAISNHMGSTAG-GHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSS 941

  Fly   472 AYIMFFE 478
            |||:|:|
  Fly   942 AYILFYE 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	91/377 (24%)
		UCH	172..477	CDD:278850	90/376 (24%)
		Asp-B-Hydro_N	<617..>731	CDD:191249
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	89/345 (26%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	90/344 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840