DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and usp42

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	XP_005169520.1	Gene:	usp42 / 327528	ZFINID:	ZDB-GENE-030131-5739	Length:	1168	Species:	Danio rerio

Alignment Length:	1097	Identity:	289/1097 - (26%)
Similarity:	441/1097 - (40%)	Gaps:	298/1097 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SVLENLKSKYIVIKPGNPGAINGFSGKNNTGKLVGANGHDNNGARKQAEHPNNQSHHINHHNHQH 136
            |..|..::|.:.:.|.....:|   |.|||.              .|.|.|..|.
Zfish    44 SATELSRAKTVCMAPAIGATVN---GSNNTA--------------LQVERPREQV---------- 81

  Fly   137 PTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLV 201
            ..::.:.:..|::||:..|.:.:.|.|..|   :|.|:.|:||||:||||||.|.:...|||:::
Zfish    82 GMTSGDGIALPQKVLFSPERLCLKWNQGHR---IGAGLHNLGNTCFLNSTLQCLTYTAPLANYML 143

  Fly   202 SEQAHLADCNVAEPGSGCIICAMTKTLLATQSNQ-SAVRPFLIYSKLKQICKHMVVGRQEDAHEF 265
            :.: |...|:  |||. |::|.|...::...:|. :.::|..:.::||:|.||...|.|||||||
Zfish   144 TRE-HSKTCH--EPGF-CMMCTMQNHIIQVFANSGNVIKPISVLNELKRIGKHFRFGSQEDAHEF 204

  Fly   266 LRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLD 330
            ||:.|:||:::.|..    .:||:..:.||.:.|||||||||.|:||:|..||.||..:.|:.|:
Zfish   205 LRYTVDAMQKSCLPG----NKLDRQTQATTFVHQIFGGYLRSRVKCLNCKAVSDTFDPYLDISLE 265

  Fly   331 IRKADSLEDAFEGHFSRERLE-DMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMI-GNKL 393
            |:.|.:|..|||.....|:|: |..|||..|||.|:|:|:|::.|:...|.|.||||:.. |.|:
Zfish   266 IKTAQTLSKAFEQFVKPEQLDGDNAYKCSKCKKMVTASKRFTVHRSSNVLTISLKRFTNFNGGKI 330

  Fly   394 TKQISFKSRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSY 458
            ||.:.:...:||..:.::|   ..:|..|.|.:::.|.|.|.|.|||........|.:|..:||.
Zfish   331 TKDVRYAEHLDLRPFMSQS---HGEPQIYALYAVLVHSGFSCHAGHYYCYIKASNGQWYQMNDSS 392

  Fly   459 VRPIAMHSVCNTNAYIMFFELDLSQAASPAANRPNG-----VRLTNGHSTTPVPAATVSSPSP-- 516
            |....:.:|.|..||::|:      ..||...  ||     :..|.|.| :|.|:..:....|
Zfish   393 VSLSDIRTVLNQQAYLLFY------IRSPDVK--NGGDFSQMNHTPGQS-SPRPSIPLKMNGPQY 448

  Fly   517 --TRFIGPQLPAG--GANGYTNGNAQKTAIQFKQQNQQSPQNGLQLGTGK-FQDTAKPPLVGAHA 576
              |.|||||||..  ..:.|.|||                      |:.| :...:||   ..:.
Zfish   449 TTTSFIGPQLPPHMLKNSSYVNGN----------------------GSSKEYHGGSKP---NRNF 488

  Fly   577 KGEATSAPTANGNKSSSPSSNSSSNHKSINQQQYLPISSDDEDIEDEMK-PRPT----------T 630
            .|.....|:   :.|||.|::|||          ||:.|  ..|.|..| |:.|          .
Zfish   489 GGVTKIGPS---HTSSSASASSSS----------LPVRS--MGIPDSSKRPKLTFLIGQGKPVRP 538

  Fly   631 AQLPSMPN---MTENHTEPKAKS--------PVKIQVK--TPVKTPLKSLVPYESASEEEE---- 678
            ||..|.||   .:.:|::..:.|        |   |||  ....|....||||...|.||.
Zfish   539 AQTQSSPNCSLSSASHSQSTSSSTSTSTSGFP---QVKQVNGTHTGASFLVPYGQESSEESDQEA 600

  Fly   679 ------------AP-------------------LPNPRKRPSG-------EDSSES---DQESG- 701
                        ||                   ||:...:.:|       |:.|:|   :..||
Zfish   601 GVLENGSTKTYLAPKITNGNGVKDDAQSHDSSSLPHHTSKTNGSNGFHVCENGSDSHVCENGSGP 665

  Fly   702 ---QTNGHSKTNGSHTNGSASSSVHVNNSKQKTDAIDEIFKSLK------KSADSDEDDDEEEPS 757
               ..||.||.||.:.|.......|.::.........|:..:||      :|::....||
Zfish   666 DHTSQNGLSKANGFNHNDKVMIDPHTSSQISDLSCCSEMELNLKPAHNESRSSNPASSDD----- 725

  Fly   758 IQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKS---KTGIWKVTRNDEVDAIEDDVDVVVVEGS 819
                   ||.....::....||..:..|.|.|:|   ::.:.|.|          |.|:.....|
Zfish   726 -------HPCSSPSNKRLNLPSESSSQSVAQIQSSPKESLVLKTT----------DTDLHTETAS 773

  Fly   820 PVKIPTPNKNHRNPFSSSKPSTDSPATPGAKRQKLLNGSALKSHQQPRVGNGYQSNATSNGSTIN 884
            .|::...:..|              ...|....::.|..:|.               .|:|.|..
Zfish   774 KVELTQRHATH--------------TATGTSDLQVNNNVSLH---------------VSHGHTSP 809

  Fly   885 ELLKQSYRGYGSPVLSWNGKPAELEKELLVD---AREQRQRDID--------DDEE------NEM 932
            ..||:.||  .|...|...||:..:|....|   :.|.|.|..|        .|.|      :..
Zfish   810 HKLKEVYR--CSEGESKEAKPSHSDKFGSGDGWRSGEDRNRGSDRPHFSSTPKDRERYRHYRDHS 872

  Fly   933 DRGRQRKVKSGSAKGNNASNSTPGY--------------------NPFQ-EYEGQKRWNKNGGGG 976
            ||.|.|  ...|.:.:..|.|...|                    :.|| .:..::.||::
Zfish   873 DRSRSR--YGHSYQDSRRSTSRERYYRDRDLERHWDRFSHHRREHHYFQRRHRDERDWNRD---- 931

  Fly   977 GFPRFYNQNYR-QNFQQRNKFKFNRFGGPGSAKFQQQRALQRHLSAGGGFSRRQPSA 1032
              .||.:.:|| ..:..||.:..:...|     .::......|...|   |:.:||:
Zfish   932 --RRFGSDSYRPSGYHNRNGYSNHSHRG-----MEEAHGRATHTVNG---SKGRPSS 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	121/308 (39%)
		UCH	172..477	CDD:278850	120/307 (39%)
		Asp-B-Hydro_N	<617..>731	CDD:191249	42/186 (23%)
usp42	XP_005169520.1	Peptidase_C19E	113..412	CDD:239126	122/315 (39%)
		UCH	114..411	CDD:278850	120/307 (39%)
		DUF1777	860..>968	CDD:285811	21/120 (18%)
		PRP38_assoc	<861..933	CDD:289628	14/79 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2617
eggNOG	1	0.900	-	-		E1_KOG1865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3156
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000177
OrthoInspector	1	1.000	-	-		otm24538
orthoMCL	1	0.900	-	-		OOG6_101457
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1006
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.860