Protein Alignment scny and usp36

DIOPT Version :9

• Sequence 1: NP_729092.1
• Gene: scny / 38648
• FlyBaseID: FBgn0260936
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: NP_001292509.1
• Gene: usp36 / 327239
• ZFINID: ZDB-GENE-030131-5450
• Length: 1104
• Species: Danio rerio
• Alignment Length: 1138
• Identity: 283/1138 - (24%)
• Similarity: 456/1138 - (40%)
• Gaps: 292/1138 - (25%)

  Fly    43 GSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFSGKNNTGKLVGA 107
            |.|...:.::||::|:.|||:|.........||.||:||:::.|.|..|
Zfish    22 GDLNKLLASSAKKVLLQKIEFEPASKGFSYQLETLKTKYVILNPKNDAA---------------- 70

  Fly   108 NGHDNNGARKQAEHPNNQSHHINHHNHQHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGT 172
                      .::.|...:......:........:.:|.|:::|:|...:.:.|   ||.::||.
Zfish    71 ----------TSQRPTEPAQIKRQISESLSVGQSDGIPAPQKMLFPGNKLSMKW---ERVYRVGA 122

  Fly   173 GMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSG-CIICAMTKTLLATQSN-Q 235
            |:.|:||||:||||:|.|.:.|.|||:|:|:: |...|:    .|| |:||.|...::...:| .
Zfish   123 GLHNLGNTCFLNSTVQCLTYTPPLANYLLSKE-HSRSCH----QSGFCMICVMQNHIIQAFANTA 182

  Fly   236 SAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQI 300
            :|::|......||:|.:|...|.|||||||||:.::||::|.|   ..|.:||:..:.||.:.||
Zfish   183 NAIKPVSFIRDLKKIARHFRFGSQEDAHEFLRYTIDAMQKACL---NGYPKLDRQTQATTLVHQI 244

  Fly   301 FGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLE-DMGYKCEGCKKKV 364
            |||||||.|:|..|..||.|:..:.|:.|:||:|.::..|.|.....:.|. :..|.|..|||||
Zfish   245 FGGYLRSRVKCSICKSVSDTYDPYLDIALEIRQAANIVRALELFVKPDVLSGENAYMCAKCKKKV 309

  Fly   365 SATKQFSLERAPITLCIQLKRF-SMIGNKLTKQISFKSRIDLSKYAARSQAAQAQPLTYRLVSMV 428
            .|||:|::.|....|.:.|||| :..|.|:||.:.:...:::..|.::|   ...|:.|.|.:::
Zfish   310 PATKRFTVHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQS---SGDPVMYGLYAVL 371

  Fly   429 THLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHSVCNTNAYIMFF---------------- 477
            .|.|.|.|.|||........|.:|..:||.|....:..|.|..||::|:
Zfish   372 VHSGYSCHAGHYYCYVKASNGQWYQMNDSMVHSSNIKVVLNQQAYVLFYLRIPEKKNTDAKQNMV 436

  Fly   478 ----------------------------ELDLSQAAS----------PAANRPNGV---RLTNG- 500
                                        :||.:|...          |.|...:|:   :|:||
Zfish   437 HSGRTNMTPEQLKKSTLNGPLSSPQVTKKLDPAQLRKIQSVDGGLGVPVARNCSGLQSPKLSNGT 501

  Fly   501 --------------------------------HSTTPVP-------------------------A 508
                                            .|:||.|                         :
Zfish   502 SNSHALLKPASGPSLIEEPLKKVKKPTAQPHSRSSTPAPSSGLHKTNSKQLPSSTSLKSLSDSSS 566

  Fly   509 ATVSSPSPTR-FIGPQLPAGGANGYTNGNAQKTAIQFKQQNQQSPQNGLQLGTGKFQDTAKPPLV 572
            |..||.|.:| .:|.:....|.....|..| ..|...::|.:..|| .|...|.:...|..||
Zfish   567 ADTSSSSESRESVGTRSAPAGDPSSVNSPA-SPAKSTEEQKKLKPQ-ALTNVTSEPISTMSPP-- 627

  Fly   573 GAHAKGEATSAPTANGNKSSSPSSNS---SSNHKSINQQQYL---------------------PI 613
              .||..|.||..|:..:|.|.|:.:   ||.|.|.:...:|                     |.
Zfish   628 --PAKRLALSAKKASVRQSLSSSTEARPPSSFHLSSDPTHFLSPASLHPHHRFSPHSLSLQSPPS 690

  Fly   614 SSDDEDIEDEMKPRPTTAQL-PSMPNMTENHTEPKAKSPVKIQVKTPVKTPL------------- 664
            :...:|:....:|..|...| |::...|..|....:..|::.|..:...|||
Zfish   691 AHLSKDLSPLKRPSSTLEPLAPALSPQTNGHQPHSSPRPIQSQNLSASTTPLLASPVVKNKKKKL 755

  Fly   665 ---KSLVPYE----SASEEEEAPLPN--------PRKRPSGEDSSESDQESGQTN---------- 704
               .|.|..|    ||.||.::...|        .|||.:..|..|..:||.:::
Zfish   756 KRSHSEVEQEYLTASAPEEPKSRAENQKKKKKKKKRKREAEADDLEGQRESVESHLEPHQDEDWC 820

  Fly   705 -GHSKTNGSHTNG-----SASSSVHVNNSKQKTDAIDEIFKSLKKSADSDEDDDEEEPSIQLTNG 763
             |.:.:.||...|     |.:..:|.|..:...:...::.|..||......:..||.     .||
Zfish   821 LGETWSIGSAAKGDEFKLSEAEEIHQNKPQSVPEKHHDLKKKKKKKKHKLAEQLEEH-----RNG 880

  Fly   764 WHPQKQS------QSQSKAPPSPKTPPSPAVIKSKTGIWKVTRNDEVDAIEDDV-DVVVVEGSPV 821
            ....|.:      .:..|.....||.......|.|..:.:..|.....::..|: :...:|.|.:
Zfish   881 ATSSKCAVVKEIGDANEKTEELRKTKKKKKKRKPKDFLEENERQSNGGSLHIDLRETNRIESSEM 945

  Fly   822 KIPTPNKNHRNPFSSSKPST----DSPATPGAKRQKLLNGSALKSHQQPRVGNGYQSNAT----- 877
            .    |.:.|.| ..|||:.    ||....|.|        :.::|::....:|.:|.|.
Zfish   946 S----NADKRKP-DKSKPAPVIVWDSQVQDGFK--------SSQNHEEAEDMSGKKSCAVPVCWD 997

  Fly   878 --SNGSTINELLKQSY-RGYGSPVLSWNGKPAELEKELLVDAREQRQRDIDDDEENEMDRGRQRK 939
              .:...:.||||.|. :.||:.||||.|.|:.:.::.:.|:|..:...:.|:.::|.|.|:.:|
Zfish   998 GKKSCDVVQELLKNSSDKAYGTEVLSWEGDPSLISRDAVQDSRYAKNLTVIDEWDSEFDSGKVKK 1062

  Fly   940 VKSGSAKGNNASNSTPGYNPFQEYEGQKRWNKN 972
            :|                    :|:..:|||.|
Zfish  1063 IK--------------------KYKKDRRWNGN 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	118/309 (38%)
		UCH	172..477	CDD:278850	117/308 (38%)
		Asp-B-Hydro_N	<617..>731	CDD:191249	34/158 (22%)
usp36	NP_001292509.1	Peptidase_C19E	121..421	CDD:239126	119/310 (38%)
		UCH	122..420	CDD:278850	117/308 (38%)
		SOBP	<610..746	CDD:291927	34/140 (24%)
		Cas10_III	<888..>1090	CDD:276222	49/221 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2617
eggNOG	1	0.900	-	-		E1_KOG1865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3156
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000177
OrthoInspector	1	1.000	-	-		otm24538
orthoMCL	1	0.900	-	-		OOG6_101457
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4814
SonicParanoid	1	1.000	-	-		X1006
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.890