DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and Usp49

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_001129942.1	Gene:	Usp49 / 316211	RGDID:	1310513	Length:	685	Species:	Rattus norvegicus

Alignment Length:	431	Identity:	105/431 - (24%)
Similarity:	161/431 - (37%)	Gaps:	116/431 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 KPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHI----------------- 193
            ||:|.|.....:              ||:.|:|||||:||.||.|.|:
  Rat   238 KPRRQLAVAPGV--------------TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSTSEH 288

  Fly   194 --PALANWLVSEQAHLADCNVA------------EPGSGCII--CAMTKTLLATQSNQSAVRPFL 242
              |...|......:..|....|            ||...|..  .:::::|...|:.:.:.:...
  Rat   289 LFPQATNGKAQIPSRPASSTAAGFSVRSDRAQGFEPQGFCWSSGASISRSLELIQNKEPSSKHIS 353

  Fly   243 IYSKLKQICKHMVVGR------------------------QEDAHEFLRFLV---------EAME 274
            :..:|..:.:.|..|:                        |:||.|||..|:         |...
  Rat   354 LCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGST 418

  Fly   275 RAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLD--------- 330
            |..|:.|...|...|::|   .:..||.|.|.|:|.|:|||:.|.|.:.|.||.|:
  Rat   419 RRILIPFSQRKLTKQVLK---VVNTIFHGQLLSQVTCVSCNYKSNTIEPFWDLSLEFPERYHCVE 480

  Fly   331 -----IRKADSLEDAFEGHFSR-ERLEDMGYKCEGCKKK-----------VSATKQFSLERAPIT 378
                 :.:.:.|.......|:. |.||...|.|:.|..|           ..|.||..:.|.|..
  Rat   481 KGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQV 545

  Fly   379 LCIQLKRFSMIG----NKLTKQISFKSRIDLSKYAARSQAAQAQPLT--YRLVSMVTHLGASQHC 437
            |.:.||||...|    .|:...:.|...:.:..|......:.....|  |.|.::|.|.|.....
  Rat   546 LRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCGDMLSSLDKDTFAYDLSAVVMHHGKGFGS 610

  Fly   438 GHYTA-IGSTDTGSFYNFDDSYVRPIAMHSVCNTNAYIMFF 477
            ||||| ..:|:.|.:.:.:||.:...::..||.|.|||:|:
  Rat   611 GHYTAYCYNTEGGFWVHCNDSKLDVCSVEEVCKTQAYILFY 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	100/404 (25%)
		UCH	172..477	CDD:278850	100/403 (25%)
		Asp-B-Hydro_N	<617..>731	CDD:191249
Usp49	NP_001129942.1	zf-UBP	26..87	CDD:396634
Usp49	NP_001129942.1	UCH	250..651	CDD:395355	100/403 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870