DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and Usp36

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	XP_038942129.1	Gene:	Usp36 / 303700	RGDID:	1309937	Length:	1098	Species:	Rattus norvegicus

Alignment Length:	1135	Identity:	277/1135 - (24%)
Similarity:	463/1135 - (40%)	Gaps:	269/1135 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SGEDTNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFSGKNNT 101
            |.||  |.|...:.|:||::|:.:||:|.........||:|||||:::.|...||
  Rat    18 SAED--GDLGKLLAASAKKVLLQRIEFEPASKSFSYQLESLKSKYVLLNPKAEGA---------- 70

  Fly   102 GKLVGANGHDNNGARKQAEHPNNQSHHINHHNHQHPTSNPNELPKPKRVLYPRENIRIGWKQSER 166
                   |...:|...||..|..:         :...|..:.:|.|::||:|.|.:.:.|   ||
  Rat    71 -------GRHRSGDEPQARKPGTE---------RMSGSGGDGVPAPQKVLFPVERLSLRW---ER 116

  Fly   167 KWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAMTKTLLAT 231
            .::||.|:.|:||||:||||:|.|.:.|.|||:|:|:: |...|:   .||.|::|.|...::..
  Rat   117 VFRVGAGLHNLGNTCFLNSTIQCLTYTPPLANYLLSKE-HARSCH---QGSFCMLCVMQNHMVQA 177

  Fly   232 QSNQ-SAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETT 295
            .:|. :|::|......||:|.:|...|.|||||||||:.::||::|.|   ..|.:||:..:.||
  Rat   178 FANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACL---NGYAKLDRQTQATT 239

  Fly   296 PLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLE-DMGYKCEG 359
            .:.|||||||||.|:|..|..||.|:..:.|:.|:||:|.::..|.|.....:.|. :..|.|..
  Rat   240 LVHQIFGGYLRSRVKCSVCRSVSDTYDPYLDIALEIRQAANIVRALELFVKSDVLSGENAYMCAK 304

  Fly   360 CKKKVSATKQFSLERAPITLCIQLKRF-SMIGNKLTKQISFKSRIDLSKYAARSQAAQAQPLTYR 423
            |||||.|:|:||:.|....|.:.|||| :..|.|:||.:.:...:::..|.::|   ...|:.|.
  Rat   305 CKKKVPASKRFSIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQS---SGDPVMYG 366

  Fly   424 LVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHSVCNTNAYIMFF----------E 478
            |.:::.|.|.|.|.|||........|.:|..:||.|....:..|.:..||::|:          |
  Rat   367 LYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLSQQAYVLFYLRIPGSKKSPE 431

  Fly   479 LDLSQAASPAANRP-------------------------------------------------NG 494
            ..:|:..:...:||                                                 :|
  Rat   432 GPVSRVGATLPSRPKVIPEHPKKSPGNGVVSSPLMAKRQDSLMMRKLQSPEEVGMPVSRNGSISG 496

  Fly   495 VRLTNGHSTTPVPAATVS---SPSPTRFIGPQL---PAGGANGYTNGNAQKTAIQFKQQNQQSPQ 553
            ::|.||.:....||.:.|   :|:||..  |.:   |        ....:|:|....:....:..
  Rat   497 LKLQNGCAPAKSPAGSPSPRLAPTPTHM--PTILDEP--------GEKVKKSAPPQSRTTSPTAS 551

  Fly   554 NGLQLGTGKFQD-------------TAKPPLV-----GAHAKGEATSAPTANGNKSSSPSSNSSS 600
            .|.. |||:.:.             :..|.|.     |...|||........|:.|||...:|:|
  Rat   552 QGFP-GTGESRSQRPGSWASRDSIFSTSPKLAKAITNGHRLKGEGNGVDLEKGDSSSSSPEHSAS 615

  Fly   601 N--------------HKSINQQQYLPISSDDEDIEDEMKPRPTTAQLPSMPNMTENHTEPKAKSP 651
            :              |...:|....|.:...:.:.:.:..:....:.|::.:.|...|...:..|
  Rat   616 SDAAKAPQTSEGRAAHVCDSQGTNCPATGHSKVLSNGVDAKMGKLKSPALSSTTTEPTSLMSPPP 680

  Fly   652 VK-------------------IQVKTP-----VKTPLKSLVPY------ESASEEEEAPLPNPRK 686
            .|                   |...:|     :.:|:|:..|.      .|.:....||.|.|..
  Rat   681 AKKLALSAKKASTLRRATGNDIGSPSPSAFCDLTSPMKATHPVVASPGPVSKTRAAAAPAPQPSP 745

  Fly   687 RP-SGEDSSESDQESGQTNGHSKTNGSHT-----NGSASSSVHVNNSKQKTDAIDEIFKSLKKSA 745
            .| |...||.|.:..|.:...|..:.:.|     ||..:|  |::...:..:|:....:..||:.
  Rat   746 HPHSASLSSSSAKPLGTSEPQSCCSSAWTPLPQVNGHFTS--HLHQLPEANEALHSPSRKRKKTP 808

  Fly   746 DSD----------------------EDDDEEEPSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAV 788
            ..|                      ....:::..::.......|::||||.: |.||:.
  Rat   809 SGDPQRLGRDTHLPQCLEGAPATARRKKRKKKKDLEGVGDTATQQESQSQDQ-PWSPRG------ 866

  Fly   789 IKSKTGIWKVTRNDEVDAIEDDV------------------------DVVVVEGSPVKIPTP--- 826
             :.:.|........:|..|.|..                        |::....||.....|
  Rat   867 -RKEEGTQLQVNGHQVSHILDSYHASSRKRRKRKRSEGLSQEATVCQDLLQHGCSPADHCEPEAR 930

  Fly   827 -------NKNHRNPFSSSKPSTDSPATPGAKRQKL--LNGSALKSH-QQPRVGNGYQSNATSN-- 879
                   .:..|.|....:..::.|....:.|..:  :....:..| ...|:|.|.....|.|
  Rat   931 TELQKKKKRRKRKPEPQQEEESEHPGYQRSPRPSVTPVPELCVNDHLPSDRLGLGRAPLVTWNRD 995

  Fly   880 --GSTINELLKQSY-RGYGSPVLSWNGKPAELEKELLVDAREQRQRDIDDDEENEMDRGRQRKVK 941
              ...:.|||:.|. ..||..||:|:|:|:.:.::.:.|:|..|.:.:.||.:.|.|||:::|:|
  Rat   996 QEPDVVQELLQDSSDTAYGKKVLTWDGEPSAISQDAMKDSRLARTQTVVDDWDEEFDRGKEKKIK 1060

  Fly   942 SGSAKGNNASNSTPGYNPFQEYEGQKR-WN 970
              ..|.....|    :|.||:.:.::. |:
  Rat  1061 --KFKREKKRN----FNAFQKLQSRRNFWS 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	116/308 (38%)
		UCH	172..477	CDD:278850	115/307 (37%)
		Asp-B-Hydro_N	<617..>731	CDD:191249	27/149 (18%)
Usp36	XP_038942129.1	Peptidase_C19E	121..421	CDD:239126	117/309 (38%)
Usp36	XP_038942129.1	Herpes_BLLF1	<493..>807	CDD:282904	62/326 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2718
eggNOG	1	0.900	-	-		E1_KOG1865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2551
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000177
OrthoInspector	1	1.000	-	-		otm46460
orthoMCL	1	0.900	-	-		OOG6_101457
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1006
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.860