DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and Usp42

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_001099379.1	Gene:	Usp42 / 288482	RGDID:	1305231	Length:	1325	Species:	Rattus norvegicus

Alignment Length:	876	Identity:	239/876 - (27%)
Similarity:	382/876 - (43%)	Gaps:	179/876 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 GAINGFSGKNN----TGKLVGANGHDNNGARKQAEHPNNQSHHINHHNHQHPTSNPNE------L 144
            ||::..|..:|    .|.:.||..::|:...::::                 .|.|.:      :
  Rat    38 GAVSSISDVSNHTLSLGPVPGAVVYNNSSVPEKSK-----------------PSPPKDQVLGDGI 85

  Fly   145 PKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLAD 209
            ..|::||:|.|.|.:.|:||.|   ||.|:.|:||||:.|:.||.|.:.|.|||:::|.: |...
  Rat    86 APPQKVLFPSEKICLKWQQSHR---VGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHE-HSKT 146

  Fly   210 CNVAEPGSGCIICAMTKTLLATQSNQ-SAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAM 273
            |: ||  ..|::|.|...:....||. ..::|..:.:::::|.:|...|.||||||||::.|:||
  Rat   147 CH-AE--GFCMMCTMQTHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAM 208

  Fly   274 ERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLE 338
            ::|.|   ....:||:..:.||.:.|||||||||.|:||:|..||.||..:.|:.|:|:.|.|:.
  Rat   209 QKACL---NGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVT 270

  Fly   339 DAFEGHFSRERLE-DMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRF-SMIGNKLTKQISFKS 401
            .|.|.....|:|: :..|||..|||.|.|:|:|::.|:...|.|.|||| :..|.|:.|.:.:..
  Rat   271 KALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTISLKRFANFTGGKIAKDVKYPE 335

  Fly   402 RIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHS 466
            .:|:..|.::   ...:|:.|.|.:::.|.|.:.|.|||........|.:|..:||.|....:.|
  Rat   336 YLDIRPYMSQ---PNGEPIIYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRS 397

  Fly   467 VCNTNAYIMFFELDLSQAASPAANRPNGVRLTNGHSTTPVPAATVSSPSP-------------TR 518
            |.|..||::|:            .|.:.|: ..|.:|.|..:...|||.|             ..
  Rat   398 VLNQQAYVLFY------------IRSHDVK-NGGETTHPAHSPGQSSPRPGISQRVVNSKQAAPG 449

  Fly   519 FIGPQLPAGGANGYTNGNAQKTAIQFKQQNQQSPQNGLQLGTGKFQDTAKPPLVGAHAKGEATSA 583
            |||||||........:.|                      ||...:||            .::|.
  Rat   450 FIGPQLPPHVMKNTPHLN----------------------GTTPVKDT------------PSSSV 480

  Fly   584 PTANGNKS---SSPSSNSSS-NHKSINQQQYLPISSDDE----DIEDEMKPRPTTAQL------- 633
            .:.|||.|   :||::.|:| .:.|:|:...:|.....:    .|.:::..|...|||
  Rat   481 SSPNGNTSVNRASPATASTSVQNWSVNRPSVIPEHPKKQKITISIHNKLPVRQGQAQLNNNLHGP 545

  Fly   634 ----PSMPNMTENHTEPKAKSPVKIQVKTPVKTPLKSLVPYESASEEEEAPLPNPRKR------- 687
                ||....:...|.|.|       :::....|..|:.|.||..:    |:.|.:.:
  Rat   546 CLEAPSKAAPSSTITNPSA-------IQSTSNAPTTSVSPSESCPK----PMVNGKAKVGSSVLV 599

  Fly   688 PSG-EDSSESDQESGQTNGHSKTNG----SHTNGSASSSVHVNNSKQKTDAIDEIFKSLKKSADS 747
            |.| |.|.|||:||   .|.:|.||    :.|..|...:...:......:..:.:..:...||||
  Rat   600 PYGAESSEESDEES---KGLAKENGVDMMTSTQSSRPETADEDGEASPHELQESVMLNGANSADS 661

  Fly   748 DEDDDE---EEPSIQLTNGWHPQ----KQSQSQSKAPPSP-KTPP---------------SPAVI 789
            |..:..   :..|.|:....|.:    |.:....|..|:| ::.|               .|||.
  Rat   662 DSRESSLAFDSASCQVQPDLHTENLFNKLNGLPGKVTPAPLQSVPEDKILETFKLTNQAKGPAVE 726

  Fly   790 KSKTGIWKVTRNDEVDAIEDDVDVVVVEGSPVKIPTPNKNHRNPFSSSKPSTDSPATPGAKRQKL 854
            :|    |..|......|.....:.:..|.||::||....|.    |...|||.||..|.....|.
  Rat   727 ES----WTTTGGSSPRASVSQPEPITDETSPLEIPEAVTNG----SMKTPSTTSPLEPTISCTKE 783

  Fly   855 LNGSALKSHQQPRVGNGYQSNATSNGSTINE 885
            .:...:.|.:...|.....:...|.|:|:.:
  Rat   784 DSSVVVVSAEPMEVLPSVPALCNSTGTTLGD 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	113/308 (37%)
		UCH	172..477	CDD:278850	112/307 (36%)
		Asp-B-Hydro_N	<617..>731	CDD:191249	32/140 (23%)
Usp42	NP_001099379.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		239/876 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..86		3/38 (8%)
		Peptidase_C19E	109..409	CDD:239126	114/321 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..502		28/119 (24%)
		Herpes_BLLF1	<423..776	CDD:282904	93/408 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..590		12/61 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..674		19/74 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..780		20/69 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	802..849		3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..1032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1146..1259
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1290..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2718
eggNOG	1	0.900	-	-		E1_KOG1865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2551
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000177
OrthoInspector	1	1.000	-	-		otm46460
orthoMCL	1	0.900	-	-		OOG6_101457
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1006
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.860