DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and ubp7

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_593108.1	Gene:	ubp7 / 2541845	PomBaseID:	SPAC23G3.08c	Length:	875	Species:	Schizosaccharomyces pombe

Alignment Length:	954	Identity:	170/954 - (17%)
Similarity:	303/954 - (31%)	Gaps:	355/954 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TANVVNAALRESLGGNSSAGSSTDQAKSGEDTNGSLQNHIVANAKRILMAKIEYEEVPNYHESVL 74
            ::.:||...:|||.. |....||...:......|...:|:..||:.:        ..|:.|...:
pombe    30 SSELVNQMKKESLAA-SVKTPSTPPKECSHLKKGVKLSHLKGNARAL--------RDPSKHLCFI 85

  Fly    75 ---ENLKSK-YIVIKPGNPGAINGFSGKNNTGKLVGANGHDNNGARKQAEHPNNQSHHI------ 129
               |.:|.: |.:....            |.|.|...| |:::.:||..|  .|:.|.:
pombe    86 CTTEKIKREDYELTLCA------------NCGYLFCCN-HESDHSRKHFE--KNKKHCVFVNIIT 135

  Fly   130 ---------------NHHN------HQHPTSN--------PNELPKPKRVLYPRENIRIGWKQSE 165
                           :..|      .|...||        ||.|..........:..:....:|.
pombe   136 LKCHCYSCDADIVIFDKKNLVVRDVQQFICSNLVSSLTKAPNVLKSNSSHFKKEKKSKHSSGKSS 200

  Fly   166 RKWQV-GTGMINVGNTCYLNSTLQALLHIPALANWLVS--EQAHLADCNVAEPGSGCIICAMTK- 226
            :|::| ..|:.|:|.||:.|||||.|....||.: ::|  :.:|          |..|:..:||
pombe   201 KKYKVISPGLKNLGATCFFNSTLQVLCACEALHD-VISPFQYSH----------SSVIVRKLTKS 254

  Fly   227 --------------TLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAY 277
                          |...:....|..||...:.:.:::........|:||||.||.|
pombe   255 PESSLLSAFIKFLETFYKSDGTISVYRPTTFFGEFRRLHPQFSESVQQDAHELLRLL-------- 311

  Fly   278 LMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFE 342
                     ||.|:.|              |.|.|..|..|:
pombe   312 ---------LDDLISE--------------EFRVLRFNLNSV----------------------- 330

  Fly   343 GHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGNKLTKQISFKSRIDLSK 407
               ||                       ||:.:|   |:      ....:|:|.::...:::::.
pombe   331 ---SR-----------------------SLQLSP---CL------TDDEQLSKSLTSFKQVNVTD 360

  Fly   408 YAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHSVCNTNA 472
                   |...|                        .|.:|......::.||   ::.|:..:..
pombe   361 -------ASLSP------------------------NSHNTSDNEQNNEDYV---SVSSLVGSET 391

  Fly   473 YIMFFELDLSQAASPAANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPAGGANGYTNGNA 537
            ..:.:..:|||::..:.::.:.....|   ::|:.|::..|          ||:......::...
pombe   392 EDITYSKELSQSSDSSQHQHDSFLPAN---SSPLAASSTKS----------LPSSELLDSSSDKG 443

  Fly   538 QKTAIQFKQQNQQSPQNGLQLGTGKFQDTAKPPLVGAHAKGEATSAPTANGNKSSSPSSNSSSNH 602
            |:.   ||.|::.:       ||..|:|                  |.::.|.|:|.:...:|..
pombe   444 QQV---FKGQHEVA-------GTNSFED------------------PNSHFNVSNSSNHEEASPK 480

  Fly   603 KSI-----NQQQYLPI------SSDDEDIE----DEMKP----------RPTTAQLPSMPNMTEN 642
            |.:     .|::.|.|      ||||..::    ||...          |.|:..:....|...|
pombe   481 KEVLKSPQFQRRSLDILRLGELSSDDMMLDKATMDEFSSSLVIKSIFTGRLTSVVMCQSCNEITN 545

  Fly   643 HTEPKAKSPVKIQV--------------------KTPVKTPLKSLVPYESASEEEEAPLPNPRKR 687
            ..||.....:.|..                    ::|.|:.:|.:|
pombe   546 TPEPIQDLSIPIHYPSSRVSRRHRFHRALRSRFSRSPKKSSVKIVV------------------- 591

  Fly   688 PSGEDSSESDQESGQTNGHSKTNGSHTNGSASSSVHVNNSKQKTDAIDEIFK-----SLKKSADS 747
                |::..|.:...|...|..|.:...|.||.    |:...|.....::.:     |:..|...
pombe   592 ----DNANDDTDQAPTTNSSSLNENLLGGHASE----NDKSLKQSPFQKLTRRLSDLSVNSSGQI 648

  Fly   748 DEDDDEEEPSIQLTNGWHPQKQSQSQSKAP--PSPKTPPSPAVIKSKTGIWKVTRNDEVDAIEDD 810
            .:.|.:...||          .|:|...:|  ..|||...  .:|:.|.:.::: .:.:.|.|:.
pombe   649 SKQDFDNSNSI----------FSESSLSSPIIEEPKTLID--CLKNFTHVEELS-GENMFACENC 700

  Fly   811 VDVVVVEGSPVKIPTPNKNHRNPFSSS-------KPSTDSPATP 847
            .:.....|||.|....:.|.:..|::|       :...|.|..|
pombe   701 CNQPNEVGSPAKGGLTSDNDKYSFNNSVYRNAYKRMLLDDPLPP 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	55/322 (17%)
		UCH	172..477	CDD:278850	55/321 (17%)
		Asp-B-Hydro_N	<617..>731	CDD:191249	23/147 (16%)
ubp7	NP_593108.1	zf-UBP	100..147	CDD:280334	10/61 (16%)
		Peptidase_C19	209..>306	CDD:271592	26/107 (24%)
		Peptidase_C19K	485..873	CDD:239132	55/300 (18%)
		UCH	<675..872	CDD:278850	15/73 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960