DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and usp-48

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_001361851.1	Gene:	usp-48 / 172782	WormBaseID:	WBGene00009267	Length:	1264	Species:	Caenorhabditis elegans

Alignment Length:	893	Identity:	173/893 - (19%)
Similarity:	299/893 - (33%)	Gaps:	263/893 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 HHNHQHPTSNPNELP---------KPKRVLYPRENIRIGWKQSERKWQVG---TGMINVGNTCYL 183
            |..|...:||..:.|         |.::::...:..:...|:.:::..:.   .|:||.||.||:
Worm    55 HDMHSSKSSNCRDNPFCIHRLGLEKFEKLITQEQETKEEAKKDQKRRDLNDQPAGLINGGNFCYV 119

  Fly   184 NSTLQALLHIPAL----------ANWLVSEQAHLADCNVAEPGSGCIICAMTKTLLATQSNQSAV 238
            ||.||...::|..          .|::..|...:   ||            ..|:||.|.....:
Worm   120 NSFLQVWFNVPEFRQLIYDFRPSENFVPPEAPRM---NV------------QATMLALQDIFYTL 169

  Fly   239 R--PFLIYSKLKQICKHM-VVGRQEDAHEF-LRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQ 299
            :  ||....|...:.|.: :...|:|:.|| |:|. .|:||. |....|.||..:.:|:
Worm   170 QTTPFNETDKTSNLGKLLRLNSEQQDSQEFGLKFF-NALERC-LPDHPNGKETLKRLKD------ 226

  Fly   300 IFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLEDMGYKCEGCKKKV 364
            :|.|...:.:.| .|...|...:....|.|:|....:|.||.:.:|..|.|:|  :||..|.|..
Worm   227 LFTGETCTRIVC-KCGQRSEREETAISLTLNIEGYCTLLDALDAYFGEEHLDD--FKCSKCNKTG 288

  Fly   365 SATKQFSLERAPITLCIQLKRFSMIG---NKLTKQISFKSRIDLSKYAARSQAAQAQPLTYRLVS 426
            ..:||....:.|..:.|||.|:....   .||...:::...|....:...:.:.......|.|.:
Worm   289 DVSKQSDYVKLPPVIVIQLNRYKYTSKGRQKLKTPMAYPREIPAKAFQRTNNSIPPPAEMYDLFA 353

  Fly   427 MVTHLGASQHCGH-YTAIGSTDTGSFYNFDDSYVRPIAMHSVCNTNAYIMFFELDLSQAASPAAN 490
            :..|.|.:..||| |..|.|.....:|.::|..:..|                     ...|...
Worm   354 VTIHEGNNAECGHYYDLIKSPLNQKWYRYNDEAIEAI---------------------PKPPGTE 397

  Fly   491 RPNGVRLTNGHSTTPVPAAT--------------VSSPSPTRFIGPQLPAGGA------------ 529
            :|...:.............|              ...|.|    .|:||....
Worm   398 KPTTAKTEKSRKKDKEKYPTDQKACYGLLYRRRDAFKPLP----HPKLPPEELIIDSKTEIEELF 458

  Fly   530 NGYTNGNAQKTAIQFKQQNQQSPQNGLQLGTGKFQDTAKPPLVGAHAKGEATSAPTANGNKSSSP 594
            .|.|....:|:  :.:..:.:...|.:::..||.:
Worm   459 EGLTKKKIEKS--EKRLYDLERRINKVKISYGKLE------------------------------ 491

  Fly   595 SSNSSSNHKSINQQQYLPISSDDEDIEDEMKPRPTTAQLPSMPNMTENHTEPKAKSPVKIQVKTP 659
              ..|..:|..|:..:||.:.    ::|.:......|:           .|.|.|.
Worm   492 --THSDKYKEANEVVFLPTTL----LQDVLAQEYEVAK-----------GEKKKKK--------- 530

  Fly   660 VKTPLKSLVPYESASEEEEAPLPNPRKRPSGEDSSESDQESGQTNGHSKTNGSHTNGSASSSVHV 724
                       :.|||.||       |:.:.||.                       :.|:::..
Worm   531 -----------KEASENEE-------KKKNEEDE-----------------------ALSAAIAA 554

  Fly   725 NNSKQKTDAIDEIFKSLKKSADSDEDDDEEEPSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVI 789
            :.:.|:..|..|...|   :|.::..||||             .:::|::   |:|:...|..|.
Worm   555 SEADQRDKASSEPSTS---AAATEAGDDEE-------------LRAESET---PNPENAESTQVA 600

  Fly   790 KSKTG-IWKVTRNDEVD----AIEDD-VDVVVVEGSPVKIPTPNKN--------HRNPFSSSKPS 840
            ..:|. |...|...::|    |:||: :..|.|....:|..|..:|        .|.|..|...:
Worm   601 IMETDEIMDTTPTKDIDILAKAMEDNALPTVEVPQPELKKRTRQQNGEVKYVYSQRTPRKSHNGT 665

  Fly   841 TDSPATPGAKRQKLLNGSALKSHQQPRVGNGYQS---------NATSNGSTINELLKQSYR---- 892
            ..:.::|..:.......:.|.||:.|..|:|..|         .|.|....|..|.:..:|
Worm   666 NGTNSSPQKQPVSSRVAALLSSHEIPTCGHGKMSIDPILYGDVKAVSRAPAIALLREYDFRVKIV 730

  Fly   893 -GYGSPVLSWNGKPAEL-----EKELLVDAREQRQ-----RDIDDDEE 929
             ..|..|...|.|..::     |...:...||.|:     ..::|||:
Worm   731 YDNGENVFPENEKERDVFIFTAEDICMECVREMREEGNFNNQLEDDEK 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	80/326 (25%)
		UCH	172..477	CDD:278850	80/322 (25%)
		Asp-B-Hydro_N	<617..>731	CDD:191249	15/113 (13%)
usp-48	NP_001361851.1	UCH	108..394	CDD:395355	80/332 (24%)
usp-48	NP_001361851.1	Ubiquitin_like_fold	1161..1264	CDD:421700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870