DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppat-Dpck and COASY

DIOPT Version :9

Sequence 1:	NP_647985.1	Gene:	Ppat-Dpck / 38647	FlyBaseID:	FBgn0035632	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001035997.2	Gene:	COASY / 80347	HGNCID:	29932	Length:	593	Species:	Homo sapiens

Alignment Length:	563	Identity:	209/563 - (37%)
Similarity:	302/563 - (53%)	Gaps:	54/563 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TGLLVV-----SNIKHLGKSLRAIEKYVN-SLYIHLNVAGSTSTTSPVPPPPVWGR-----LISQ 58
            :||||:     |....|...|.:..:.|| :||:||....|....:.....||...     .|:.
Human    35 SGLLVLTTPLASLAPRLASILTSAARLVNHTLYVHLQPGMSLEGPAQPQSSPVQATFEVLDFITH 99

  Fly    59 LYANSSSYVGKQLDLRVLVSPLR-------PGANGSLKLRQPVDLIFSD-------AHHP----- 104
            |||.:.  |.:.||:|:|::.:|       |.......|..|.:::.:|       .::|
Human   100 LYAGAD--VHRHLDVRILLTNIRTKSTFLPPLPTSVQNLAHPPEVVLTDFQTLDGSQYNPVKQQL 162

  Fly   105 --------ELCDRLR-----ADLNISK-PTIFLDDSVISDLSAQQ----DDTQPPKVYPSVVLGG 151
                    ..|.||.     :|..|.: |...||..:.|.:....    ...||.:.|....:||
Human   163 VRYATSCYSCCPRLASVLLYSDYGIGEVPVEPLDVPLPSTIRPASPVAGSPKQPVRGYYRGAVGG 227

  Fly   152 TFDRIHLGHKIFLTQAVLRTCKRLVVGVTTSAMTKGKTLPDLILPVEERIARLREFLVDIDDTLQ 216
            ||||:|..||:.|:.|.:...::|||||....:.|.|.||:|:.|..||:..|.||||||..:|.
Human   228 TFDRLHNAHKVLLSVACILAQEQLVVGVADKDLLKSKLLPELLQPYTERVEHLSEFLVDIKPSLT 292

  Fly   217 YEIVPIDDPFGPTQVDPDLDMIVVSAETLRGGQKVNEVRSAKQLRELEIFVIDIVESNVHDGIHE 281
            ::::|:.||:||...||.|:.:|||.||.|||..:|..|....|.||.::.|.:::...|....|
Human   293 FDVIPLLDPYGPAGSDPSLEFLVVSEETYRGGMAINRFRLENDLEELALYQIQLLKDLRHTENEE 357

  Fly   282 TKVSSSNTRIDLLGTRWRRPEPRPQLPPRPYIIGLTGGIASGKSKMGERLANMGAHVIDCDKVAH 346
            .|||||:.|..:||...|.|..||:||...|:|||||...||||.:.:||..:||.|||.|.:.|
Human   358 DKVSSSSFRQRMLGNLLRPPYERPELPTCLYVIGLTGISGSGKSSIAQRLKGLGAFVIDSDHLGH 422

  Fly   347 DVYEPGQLCYTRIVQHFGQGIVSDDGRIDRSKLGPLVFADPKQLQALNGIVWPELIAEVNR-RLD 410
            ..|.||...|..:|:.||..|:..||.|:|..||..||.:.|||:.|..|:|| :||::.| .:|
Human   423 RAYAPGGPAYQPVVEAFGTDILHKDGIINRKVLGSRVFGNKKQLKILTDIMWP-IIAKLAREEMD 486

  Fly   411 ALRSQADVPRVVVLEAAVLLRAGWETNCHEVWSMIVPPDEAVRRIIERNKLSEVEAQKRLASQVP 475
              |:.|:..||.|::|||||.|||:...||||:.::|..||||||:||:.|||..||.||.||:.
Human   487 --RAVAEGKRVCVIDAAVLLEAGWQNLVHEVWTAVIPETEAVRRIVERDGLSEAAAQSRLQSQMS 549

  Fly   476 NSEIVAKSHVIFSSQWDHEFTQKQAERAWKMLTKELDSYQSSL 518
            ..::|.:|||:.|:.|:...||:|.|:||.:|.|.:.....:|
Human   550 GQQLVEQSHVVLSTLWEPHITQRQVEKAWALLQKRIPKTHQAL 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppat-Dpck	NP_647985.1	PPAT_CoAS	147..290	CDD:173915	61/142 (43%)
		CoaE	311..510	CDD:223315	94/199 (47%)
		DPCK	313..494	CDD:238980	86/181 (48%)
COASY	NP_001035997.2	PPAT_CoAS	222..368	CDD:173915	62/145 (43%)
		CoaE	388..588	CDD:223315	95/202 (47%)
		DPCK	389..565	CDD:238980	85/178 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148957
Domainoid	1	1.000	159	1.000	Domainoid score	I4103
eggNOG	1	0.900	-	-		E1_COG0237
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11889
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2496
Isobase	1	0.950	-	0	Normalized mean entropy	S2476
OMA	1	1.010	-	-		QHG49089
OrthoDB	1	1.010	-	-		D1543581at2759
OrthoFinder	1	1.000	-	-		FOG0005202
OrthoInspector	1	1.000	-	-		oto90104
orthoMCL	1	0.900	-	-		OOG6_101466
Panther	1	1.100	-	-	LDO	PTHR10695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4246
SonicParanoid	1	1.000	-	-		X3717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750