Protein Alignment Ppat-Dpck and Coasy

DIOPT Version :9

• Sequence 1: NP_647985.1
• Gene: Ppat-Dpck / 38647
• FlyBaseID: FBgn0035632
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_001292911.1
• Gene: Coasy / 71743
• MGIID: 1918993
• Length: 563
• Species: Mus musculus
• Alignment Length: 560
• Identity: 197/560 - (35%)
• Similarity: 299/560 - (53%)
• Gaps: 52/560 - (9%)

  Fly     5 TGLLVVSN-----IKHLGKSLRAIEKYVN-SLYIHL----NVAG-STSTTSPVPPPPVWGRLISQ 58
            :||||::.     ...|...|.:..:.|| :||:||    |:.| :....|||.........|:.
Mouse     6 SGLLVLTTPLATLAARLPPILTSASRLVNHTLYVHLQPGMNLGGPAQPQASPVQATFEVLDFITH 70

  Fly    59 LYANSSSYVGKQLDLRVLVSPLR------PGANGSLKLRQPVDLIFSD----------------- 100
            ||..:..:  :.||:|:|::.::      |..:....|..|.:::.:|
Mouse    71 LYTGADLH--RHLDVRILLTNIQTKSTFLPVLSSVQNLAHPPEVVLTDFQTLDGSQYNPVKQQLE 133

  Fly   101 -------AHHPELCDRL------RADLNISKPTIFLDDSVISDLSAQQDDTQPPKVYPSVVLGGT 152
                   :..|:|...|      ..:|.:..|...|..::.......:...||.:.|....:|||
Mouse   134 RYATSCYSCSPQLASVLLYPDYGTGELPLEPPNALLPSTIRPASPVARSPRQPVRGYHRGAVGGT 198

  Fly   153 FDRIHLGHKIFLTQAVLRTCKRLVVGVTTSAMTKGKTLPDLILPVEERIARLREFLVDIDDTLQY 217
            |||:|..||:.|:.|.:...::|||||....:.|.|.||:|:.|..||:..|.||||||..:|.:
Mouse   199 FDRLHNAHKVLLSVACVLAQEQLVVGVADKDLLKSKLLPELLQPYAERVEHLTEFLVDIKPSLTF 263

  Fly   218 EIVPIDDPFGPTQVDPDLDMIVVSAETLRGGQKVNEVRSAKQLRELEIFVIDIVESNVHDGIHET 282
            |:||:.||:||...||.|:.:|||.||.|||..||..|......||.::.|.:::...|:...|.
Mouse   264 ELVPLLDPYGPAGSDPTLEFLVVSEETYRGGMAVNRFRLENGKEELALYQIQLLKDQSHNENEED 328

  Fly   283 KVSSSNTRIDLLGTRWRRPEPRPQLPPRPYIIGLTGGIASGKSKMGERLANMGAHVIDCDKVAHD 347
            |||||:.|..:||...:.|..||:||...|::||||...||||.:.:||.|:||::||.|.:.|.
Mouse   329 KVSSSSFRQRILGNLLQPPNERPELPSGLYVLGLTGISGSGKSSVAQRLKNLGAYIIDSDHLGHR 393

  Fly   348 VYEPGQLCYTRIVQHFGQGIVSDDGRIDRSKLGPLVFADPKQLQALNGIVWPELIAEVNRRLDAL 412
            .|.||...|..:|:.||..|:..||.|:|..||..||.:.||::.|..||||.:.......:|.
Mouse   394 AYAPGGPAYQPVVEAFGTDILHKDGTINRKVLGSRVFGNKKQMKILTDIVWPVIAKLAREEMDV- 457

  Fly   413 RSQADVPRVVVLEAAVLLRAGWETNCHEVWSMIVPPDEAVRRIIERNKLSEVEAQKRLASQVPNS 477
             :.|....:.|::||:||.|||::..||||::::|..||||||:||:.|||..||.||.||:...
Mouse   458 -AVAKGKTLCVIDAAMLLEAGWQSMVHEVWTVVIPETEAVRRIVERDGLSEAAAQSRLQSQMSGQ 521

  Fly   478 EIVAKSHVIFSSQWDHEFTQKQAERAWKMLTKEL-DSYQS 516
            ::|.:|:|:.|:.|:...||.|.|:||.:|.|.| .:||:
Mouse   522 QLVEQSNVVLSTLWESHVTQSQVEKAWNLLQKRLPKAYQT 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppat-Dpck	NP_647985.1	PPAT_CoAS	147..290	CDD:173915	63/142 (44%)
		CoaE	311..510	CDD:223315	85/198 (43%)
		DPCK	313..494	CDD:238980	77/180 (43%)
Coasy	NP_001292911.1	Phosphopantetheine adenylyltransferase	179..357		74/177 (42%)
		PPAT_CoAS	192..338	CDD:173915	64/145 (44%)
		CoaE	358..557	CDD:223315	87/200 (44%)
		DPCK	359..535	CDD:238980	76/177 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839020
Domainoid	1	1.000	154	1.000	Domainoid score	I4261
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11889
Inparanoid	1	1.050	320	1.000	Inparanoid score	I2511
Isobase	1	0.950	-	0	Normalized mean entropy	S2476
OMA	1	1.010	-	-		QHG49089
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005202
OrthoInspector	1	1.000	-	-		oto93679
orthoMCL	1	0.900	-	-		OOG6_101466
Panther	1	1.100	-	-	LDO	PTHR10695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4246
SonicParanoid	1	1.000	-	-		X3717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.840