DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppat-Dpck and coasy

DIOPT Version :9

Sequence 1:	NP_647985.1	Gene:	Ppat-Dpck / 38647	FlyBaseID:	FBgn0035632	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001004577.1	Gene:	coasy / 447838	ZFINID:	ZDB-GENE-040912-137	Length:	554	Species:	Danio rerio

Alignment Length:	561	Identity:	205/561 - (36%)
Similarity:	314/561 - (55%)	Gaps:	62/561 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STGLLVVSNIKH---------LGKSLRAIEKYVNSLYIHLNVA---GSTSTTSPVPPPPVWG--R 54
            |||:||:::..|         |..:.:.:|:   :||:||:..   |:.....||..|||..  .
Zfish     5 STGILVLTSPLHVLPLRIAPVLTSAAQVVER---TLYVHLHPGLNLGTGGQVRPVYIPPVVDLCT 66

  Fly    55 LISQLYANSSSYVGKQLDLRVLVSPLR------PGANGSLKLRQPVDLIFSDAHHPEL------- 106
            |||:||:|::...| .||:|||::.:|      ..|||.....|.:      :|.||:
Zfish    67 LISRLYSNAADICG-HLDVRVLLTNIRGQSAASSAANGPFPAPQTL------SHSPEVVLTDFPI 124

  Fly   107 -----------CDRLRA-DLNISKPTIFLDDSV-----ISDLSAQQD---DTQPPKVYPSVVLGG 151
                       |.|..| ...:..|.:   .||     :.::|..:|   ..:|.:.:..||:||
Zfish   125 PDSGQSSLITQCLRKYAGHCYVCTPGL---SSVLLHPQLKEVSGDEDRGAQMKPLETFSDVVVGG 186

  Fly   152 TFDRIHLGHKIFLTQAVLRTCKRLVVGVTTSAMTKGKTLPDLILPVEERIARLREFLVDIDDTLQ 216
            ||||:|..||..|..:.|...:|.::||....:.|.|.|.:||.|.::|:.:|.:||.|:..:|:
Zfish   187 TFDRLHGAHKTLLNISCLMANRRFIIGVCDQELLKNKVLKELIEPYDQRVEKLHDFLNDVKPSLK 251

  Fly   217 YEIVPIDDPFGPTQVDPDLDMIVVSAETLRGGQKVNEVRSAKQLRELEIFVIDIVESNVHDGIHE 281
            |:|||:.|||||:..:|:|..||||.||.:||:.||:.|....|.||.::.|.:::......|.|
Zfish   252 YDIVPLSDPFGPSITEPELQCIVVSEETRKGGEAVNKRRVQNGLAELVLYEIPLLKDAHRADIEE 316

  Fly   282 TKVSSSNTRIDLLGTRWRRPEPRPQLPPRPYIIGLTGGIASGKSKMGERLANMGAHVIDCDKVAH 346
            .|:|||:.|..||||..:.|.|...||..||:||||||..||||.:..||.::||..||||.:.|
Zfish   317 EKISSSSLRTRLLGTLLKPPSPELDLPLCPYVIGLTGGSGSGKSSIARRLEDLGAERIDCDLLGH 381

  Fly   347 DVYEPGQLCYTRIVQHFGQGIVSDDGRIDRSKLGPLVFADPKQLQALNGIVWPELIAEVNRRLDA 411
            :.|.|....|.|::|.||..|:::|..|:|..||..||.:.::|:||..|||||:...|.:|:|.
Zfish   382 EAYLPETSAYHRVIQEFGTDILNEDKSINRRVLGGKVFGNQERLKALTDIVWPEIARLVKKRIDQ 446

  Fly   412 LRSQADVPRVVVLEAAVLLRAGWETNCHEVWSMIVPPDEAVRRIIERNKLSEVEAQKRLASQVPN 476
            .:.|.  .||.|::|||||.|||....||||...:|.:|||:||::|:.:.|.:|.:||.||.||
Zfish   447 AKQQG--KRVCVVDAAVLLEAGWTHLVHEVWVATIPEEEAVKRIVQRDGVKEEDAVRRLKSQWPN 509

  Fly   477 SEIVAKSHVIFSSQWDHEFTQKQAERAWKMLTKELDSYQSS 517
            ::::..::|:..:.|:.|.||||..:||.:|.:.:...|.:
Zfish   510 AKLIDYANVVLCTLWEPEVTQKQVLKAWSLLQQRIQKRQET 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppat-Dpck	NP_647985.1	PPAT_CoAS	147..290	CDD:173915	60/142 (42%)
		CoaE	311..510	CDD:223315	88/198 (44%)
		DPCK	313..494	CDD:238980	78/180 (43%)
coasy	NP_001004577.1	PPAT_CoAS	182..323	CDD:173915	59/140 (42%)
		CoaE	346..544	CDD:223315	88/199 (44%)
		DPCK	348..527	CDD:238980	78/180 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582918
Domainoid	1	1.000	159	1.000	Domainoid score	I4069
eggNOG	1	0.900	-	-		E1_COG0237
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11889
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2363
OMA	1	1.010	-	-		QHG49089
OrthoDB	1	1.010	-	-		D1543581at2759
OrthoFinder	1	1.000	-	-		FOG0005202
OrthoInspector	1	1.000	-	-		oto39189
orthoMCL	1	0.900	-	-		OOG6_101466
Panther	1	1.100	-	-	LDO	PTHR10695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4246
SonicParanoid	1	1.000	-	-		X3717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800