DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppat-Dpck and coasy

DIOPT Version :9

Sequence 1:	NP_647985.1	Gene:	Ppat-Dpck / 38647	FlyBaseID:	FBgn0035632	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_002942317.1	Gene:	coasy / 100490454	XenbaseID:	XB-GENE-996485	Length:	557	Species:	Xenopus tropicalis

Alignment Length:	552	Identity:	206/552 - (37%)
Similarity:	311/552 - (56%)	Gaps:	60/552 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TGLLVVSN-----IKHLGKSLRAIEKYV-NSLYIHL---------NVAGSTSTTSPVPPPPVWGR 54
            ||:|::::     ...|...|.:..|.| ::||:|.         :..||||    :|.......
Frog     6 TGVLILTSPLSALAVRLAPILASASKIVQDTLYVHFQPGLLLTGPSQPGSTS----IPATSEVCS 66

  Fly    55 LISQLYANSSSYVGKQLDLRVLVS----------PLRPGANGSLKLRQPVDLIFSD-------AH 102
            |||:||:::.|:.  .||:|||::          ||....|    |..|.:::.:|       .:
Frog    67 LISRLYSDADSHT--HLDIRVLLTNINNQSPQQLPLASVQN----LSHPPEVVLTDFQSSDGGQY 125

  Fly   103 HP--ELCDRLRADL-----NISKPTIFLD-----DSVISDLSAQQDDTQPPKVYPSVVLGGTFDR 155
            :|  :..:|..|:.     |::...::.|     :.:.||.:|  |.|.  :.|..||:||||||
Frog   126 NPAKQQLERYAANCYSCQPNLASVLLYPDYGSPGELIPSDSAA--DTTL--ESYSDVVVGGTFDR 186

  Fly   156 IHLGHKIFLTQAVLRTCKRLVVGVTTSAMTKGKTLPDLILPVEERIARLREFLVDIDDTLQYEIV 220
            :|..|||.|:...|....||:||:....:.:.|.|.:||.|.|:|:.:|.:||||:..:|.|::|
Frog   187 LHNAHKILLSVCCLLAETRLLVGMADKELLESKVLKELIEPYEQRVEKLSQFLVDVKPSLLYDVV 251

  Fly   221 PIDDPFGPTQVDPDLDMIVVSAETLRGGQKVNEVRSAKQLRELEIFVIDIVESNVHDGIHETKVS 285
            ||.||:||:..||||..||||.||.|||..||..|...:|.||.:..|.:|:...|....|.|:|
Frog   252 PICDPYGPSITDPDLKCIVVSEETQRGGLAVNRKRQENELSELAVHEIKLVKDARHAENEEEKIS 316

  Fly   286 SSNTRIDLLGTRWRRPEPRPQLPPRPYIIGLTGGIASGKSKMGERLANMGAHVIDCDKVAHDVYE 350
            ||:.|..||||..|..:....:|.:||:||||||..||||.:.:||.::||.||||||:.|..|.
Frog   317 SSSFRNRLLGTLLRPLKVNNSIPAKPYVIGLTGGSGSGKSSIAKRLEDLGAAVIDCDKLGHQCYM 381

  Fly   351 PGQLCYTRIVQHFGQGIVSDDGRIDRSKLGPLVFADPKQLQALNGIVWPELIAEVNRRLDALRSQ 415
            ||...|.:::..||..|:..||.|||..:|..||.|.:||:.|..||||.:.....:.::...||
Frog   382 PGGPAYEQVINEFGSDILCPDGTIDRKAMGSKVFTDKEQLKKLTDIVWPAIAMLAKKTMEEAASQ 446

  Fly   416 ADVPRVVVLEAAVLLRAGWETNCHEVWSMIVPPDEAVRRIIERNKLSEVEAQKRLASQVPNSEIV 480
            .  ..|.||:|||||.|||.:..||||::|:|..|||.|::.|:.:||.:|:||||:|:.:|:.|
Frog   447 G--ISVCVLDAAVLLEAGWNSMVHEVWTVIIPEKEAVTRVMGRDGISEEQAKKRLANQMSSSQRV 509

  Fly   481 AKSHVIFSSQWDHEFTQKQAERAWKMLTKELD 512
            ..|.|:..:.|:.:.||||.::||.:|.:.::
Frog   510 QLSDVVLCTIWEPDVTQKQVQKAWDLLQQRIN 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppat-Dpck	NP_647985.1	PPAT_CoAS	147..290	CDD:173915	66/142 (46%)
		CoaE	311..510	CDD:223315	90/198 (45%)
		DPCK	313..494	CDD:238980	81/180 (45%)
coasy	XP_002942317.1	PPAT_CoAS	178..323	CDD:173915	67/144 (47%)
coasy	XP_002942317.1	DPCK	344..518	CDD:238980	80/175 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3988
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11889
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2443
OMA	1	1.010	-	-		QHG49089
OrthoDB	1	1.010	-	-		D1543581at2759
OrthoFinder	1	1.000	-	-		FOG0005202
OrthoInspector	1	1.000	-	-		oto103909
Panther	1	1.100	-	-	LDO	PTHR10695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4246
SonicParanoid	1	1.000	-	-		X3717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110