DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10576 and ATG2

DIOPT Version :9

Sequence 1:	NP_001286949.1	Gene:	CG10576 / 38645	FlyBaseID:	FBgn0035630	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_850679.1	Gene:	ATG2 / 824343	AraportID:	AT3G51800	Length:	401	Species:	Arabidopsis thaliana

Alignment Length:	402	Identity:	182/402 - (45%)
Similarity:	252/402 - (62%)	Gaps:	29/402 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DVEKEPEKTIAEDLVVTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKVYK-K 66
            |...|.|.::....||||||.|.|||||.|:.|:..|...|.:.:||.:||:.:.|:|..:|| .
plant     5 DERDEKELSLTSPEVVTKYKSAAEIVNKALQVVLAECKPKAKIVDICEKGDSFIKEQTASMYKNS 69

  Fly    67 EKDLKKGIAFPTCLSVNNCVCHFSPAKNDADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAA 131
            :|.:::|:|||||:||||.|.||||..:| :..|:.||:||||:|.|||||||:..||.|:   .
plant    70 KKKIERGVAFPTCISVNNTVGHFSPLASD-ESVLEDGDMVKIDMGCHIDGFIALVGHTHVL---Q 130

  Fly   132 DQKISGRQADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISESYKCKPIEGMLSHELKQFKID 196
            :..:|||:||||.||..|...||||::.|..|..:|:|:|:::.:|.||.:||:|||:|||..||
plant   131 EGPLSGRKADVIAAANTAADVALRLVRPGKKNTDVTEAIQKVAAAYDCKIVEGVLSHQLKQHVID 195

  Fly   197 GEKTIIQNPS-EAQRKEHEKCTFETYEVYAIDVIVSTGEGVGREKDTK-VSIYKKSEE-NYMLKM 258
            |.|.::...| |....|.|   ||..||||||::.|||:|..:..|.| .:||||.|. ||.|||
plant   196 GNKVVLSVSSPETTVDEVE---FEENEVYAIDIVASTGDGKPKLLDEKQTTIYKKDESVNYQLKM 257

  Fly   259 KASRALLAEVKTKYGNMPFNIRSFEEETKARMGVVECVGHKMIEPFQVLYEK---------PSEI 314
            ||||.:::|:|..:..|||..||.||: :||:|:||||.|..::|:.|||||         |.:.
plant   258 KASRFIISEIKQNFPRMPFTARSLEEK-RARLGLVECVNHGHLQPYPVLYEKPGSCRFGFLPGDF 321

  Fly   315 VAQFKHTVLLMPNGVNLVTGIPFEAENYVSEYSVAQEELKTLLAQPLGPVKGKGKGKKA-TAG-- 376
            |||.|.||||||||.:.:|....:.   :.:.::...|:|..||..:...||.||.||| .||
plant   322 VAQIKFTVLLMPNGSDRITSHTLQE---LPKKTIEDPEIKGWLALGIKKKKGGGKKKKAQKAGEK 383

  Fly   377 --AATKVETAPA 386
              |:|:.|...|
plant   384 GEASTEAEPMDA 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10576	NP_001286949.1	APP_MetAP	3..361	CDD:294199	169/370 (46%)
ATG2	NP_850679.1	crvDNA_42K	1..394	CDD:273105	181/399 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	188	1.000	Domainoid score	I968
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4513
Inparanoid	1	1.050	311	1.000	Inparanoid score	I740
OMA	1	1.010	-	-		QHG54050
OrthoDB	1	1.010	-	-		D834026at2759
OrthoFinder	1	1.000	-	-		FOG0002945
OrthoInspector	1	1.000	-	-		oto4100
orthoMCL	1	0.900	-	-		OOG6_101895
Panther	1	1.100	-	-	LDO	PTHR10804
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1946
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840