DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10576 and pa2g4b

DIOPT Version :9

Sequence 1:	NP_001286949.1	Gene:	CG10576 / 38645	FlyBaseID:	FBgn0035630	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_997806.1	Gene:	pa2g4b / 323462	ZFINID:	ZDB-GENE-030131-2182	Length:	394	Species:	Danio rerio

Alignment Length:	392	Identity:	211/392 - (53%)
Similarity:	274/392 - (69%)	Gaps:	1/392 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADVEKEPEKTIAEDLVVTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKVYK 65
            |:..:.:.|:|||:||||||||:..:|.|..||.||.......||..:|.:||..:..||.||:|
Zfish     1 MSGDDDQQEQTIADDLVVTKYKMGADIANLALKTVIEAAKPGVSVLSLCEKGDAFIAAETSKVFK 65

  Fly    66 KEKDLKKGIAFPTCLSVNNCVCHFSPAKNDADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAA 130
            |||::|||||||||:|||||||||||.|:|.||.||.||:||||||.|:||||:..||:.||||.
Zfish    66 KEKEIKKGIAFPTCVSVNNCVCHFSPIKSDPDYMLKDGDLVKIDLGVHVDGFISNVAHSFVVGAT 130

  Fly   131 ADQKISGRQADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISESYKCKPIEGMLSHELKQFKI 195
            .|..::||:||||.||:...:|||||:|.|..|..:|:|..:|::|:||.||||||||:|||..|
Zfish   131 KDAPVTGRKADVIKAAHLCAEAALRLVKPGNQNSQVTEAWNKIAQSFKCMPIEGMLSHQLKQHVI 195

  Fly   196 DGEKTIIQNPSEAQRKEHEKCTFETYEVYAIDVIVSTGEGVGREKDTKVSIYKKS-EENYMLKMK 259
            ||||||||||::.|||:|||..||.:||||:||:||||||..|:...:.::||:. .:.|.||||
Zfish   196 DGEKTIIQNPTDQQRKDHEKAEFEVHEVYAVDVLVSTGEGKARDSGQRTTVYKRDPSKQYGLKMK 260

  Fly   260 ASRALLAEVKTKYGNMPFNIRSFEEETKARMGVVECVGHKMIEPFQVLYEKPSEIVAQFKHTVLL 324
            .||...:||:.::..|||.:|:||:|:|||:|||||..|::::||.||:||..|.|||||.||||
Zfish   261 TSRMFFSEVERRFDAMPFTLRAFEDESKARLGVVECAKHELLQPFSVLHEKEGEHVAQFKFTVLL 325

  Fly   325 MPNGVNLVTGIPFEAENYVSEYSVAQEELKTLLAQPLGPVKGKGKGKKATAGAATKVETAPAVET 389
            |.||...:|...||.|.|.|||.|...|||.||.........|.|.|||:..|.:........|:
Zfish   326 MANGPLRITSGLFEPELYKSEYEVQDPELKALLQSSASRKAQKKKKKKASKNAESATGQPVEAES 390

  Fly   390 KA 391
            :|
Zfish   391 EA 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10576	NP_001286949.1	APP_MetAP	3..361	CDD:294199	202/358 (56%)
pa2g4b	NP_997806.1	crvDNA_42K	1..387	CDD:273105	209/385 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1871
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4513
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1794
OMA	1	1.010	-	-		QHG54050
OrthoDB	1	1.010	-	-		D375525at33208
OrthoFinder	1	1.000	-	-		FOG0002945
OrthoInspector	1	1.000	-	-		otm26050
orthoMCL	1	0.900	-	-		OOG6_101895
Panther	1	1.100	-	-	O	PTHR10804
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2037
SonicParanoid	1	1.000	-	-		X1946
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870