DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10576 and Metap1

DIOPT Version :9

Sequence 1:	NP_001286949.1	Gene:	CG10576 / 38645	FlyBaseID:	FBgn0035630	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_001099946.1	Gene:	Metap1 / 295500	RGDID:	1305545	Length:	386	Species:	Rattus norvegicus

Alignment Length:	267	Identity:	59/267 - (22%)
Similarity:	87/267 - (32%)	Gaps:	92/267 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 FP--TCLSVNNCVCHFSPAKNDADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAADQKISGR 138
            ||  .|.|||..:||..|.:.    .|:.||:|.:|:..:.:|:......|..||
  Rat   189 FPKSCCTSVNEVICHGIPDRR----PLQEGDIVNVDITLYRNGYHGDLNETFFVG---------- 239

  Fly   139 QADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISESYKCKPIEGMLSHELKQFKIDGEKTIIQ 203
              ||...|...||.....|...      .|||         ||  |:...||        ..|||
  Rat   240 --DVDEGARKLVQTTYECLMQA------VDAV---------KP--GVRYREL--------GNIIQ 277

  Fly   204 NPSEAQRKEHEKCTFETYEVYAIDVIVSTGEGVGREKDTKVSIYKKSEENYMLKMKASRALLAEV 268
            ..::|.       .|.....|.       |.|:.:...|..::...::...:..||:......|.
  Rat   278 KHAQAN-------GFSVVRSYC-------GHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEP 328

  Fly   269 KTKYGNMPFNIRSFEEET-------KARMGVVECVGHKMIEPFQVLYEKPSEIVAQFKHTVLLMP 326
            ....|       .:::||       ..|.|                  |.|   |||:||:|:..
  Rat   329 MICEG-------GWQDETWPDGWTAVTRDG------------------KRS---AQFEHTLLVTD 365

  Fly   327 NGVNLVT 333
            .|..::|
  Rat   366 TGCEILT 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10576	NP_001286949.1	APP_MetAP	3..361	CDD:294199	59/267 (22%)
Metap1	NP_001099946.1	zf-C6H2	12..53	CDD:292429
		PLN03158	14..382	CDD:215607	59/267 (22%)
		MetAP1	136..373	CDD:238519	59/267 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900