Protein Alignment CG10576 and Pa2g4

DIOPT Version :10

• Sequence 1: NP_647984.1
• Gene: CG10576 / 38645
• FlyBaseID: FBgn0035630
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_001004206.1
• Gene: Pa2g4 / 288778
• RGDID: 1302994
• Length: 394
• Species: Rattus norvegicus
• Alignment Length: 386
• Identity: 212/386 - (54%)
• Similarity: 277/386 - (71%)
• Gaps: 3/386 - (0%)

  Fly     1 MADVEKEPEKTIAEDLVVTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKVYK 65
            |:..:::.|:||||||||||||:.|:|.|:.|::::.......||..:|.:||..:.|||||::|
  Rat     1 MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFK 65

  Fly    66 KEKDLKKGIAFPTCLSVNNCVCHFSPAKNDADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAA 130
            |||::||||||||.:|||||||||||.|:|.||.||.||:||||||.|:|||||..|||.|:|.|
  Rat    66 KEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVA 130

  Fly   131 ADQKISGRQADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISESYKCKPIEGMLSHELKQFKI 195
            ...:::||:||||.||:...:|||||:|.|..|..:|:|..:::.|:.|.||||||||:|||..|
  Rat   131 QGSQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVI 195

  Fly   196 DGEKTIIQNPSEAQRKEHEKCTFETYEVYAIDVIVSTGEGVGREKDTKVSIYKKS-EENYMLKMK 259
            ||||||||||::.|:|:|||..||.:||||:||:||:|||..::...:.:|||:. .:.|.||||
  Rat   196 DGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMK 260

  Fly   260 ASRALLAEVKTKYGNMPFNIRSFEEETKARMGVVECVGHKMIEPFQVLYEKPSEIVAQFKHTVLL 324
            .|||..:||:.::..|||.:|:||:|.|||||||||..|::::||.|||||..|.|||||.||||
  Rat   261 TSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLL 325

  Fly   325 MPNGVNLVTGIPFEAENYVSEYSVAQEELKTLLAQPLGPVKGKGKGKKA--TAGAATKVET 383
            ||||...:|..|||.:.|.||..|...|||.||.........|.|.|||  ||..||..||
  Rat   326 MPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGET 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10576	NP_647984.1	APP_MetAP	3..361	CDD:469704	200/358 (56%)
Pa2g4	NP_001004206.1	crvDNA_42K	1..388	CDD:273105	212/386 (55%)
		Necessary for nucleolar localization. /evidence=ECO:0000250|UniProtKB:Q9UQ80	2..48		19/45 (42%)
		RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9UQ80	46..54		2/7 (29%)
		Necessary for nucleolar localization. /evidence=ECO:0000250|UniProtKB:Q9UQ80	301..394		45/86 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..394		12/29 (41%)
		Interaction with RNA. /evidence=ECO:0000250|UniProtKB:P50580	361..375		4/13 (31%)