DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10576 and METAP1

DIOPT Version :9

Sequence 1:	NP_001286949.1	Gene:	CG10576 / 38645	FlyBaseID:	FBgn0035630	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_055958.2	Gene:	METAP1 / 23173	HGNCID:	15789	Length:	386	Species:	Homo sapiens

Alignment Length:	115	Identity:	27/115 - (23%)
Similarity:	49/115 - (42%)	Gaps:	11/115 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 FP--TCLSVNNCVCHFSPAKNDADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAADQKISGR 138
            ||  .|.|||..:||..|.:.    .|:.||:|.:|:..:.:|:......|..||...|   ..|
Human   189 FPKSCCTSVNEVICHGIPDRR----PLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDD---GAR 246

  Fly   139 QADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISESYKCKPIEGMLSH 188
            :  ::...|..:..|:..:|.|.....|.:.:|:.:::.....:.....|
Human   247 K--LVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGH 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10576	NP_001286949.1	APP_MetAP	3..361	CDD:294199	27/115 (23%)
METAP1	NP_055958.2	Zinc finger-like, important for proper ribosome association. /evidence=ECO:0000255\|HAMAP-Rule:MF_03174	9..52
		zf-C6H2	12..53	CDD:292429
		PLN03158	14..382	CDD:215607	27/115 (23%)
		MetAP1	136..373	CDD:238519	27/115 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900