DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10576 and Pa2g4

DIOPT Version :9

Sequence 1:	NP_001286949.1	Gene:	CG10576 / 38645	FlyBaseID:	FBgn0035630	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_035249.1	Gene:	Pa2g4 / 18813	MGIID:	894684	Length:	394	Species:	Mus musculus

Alignment Length:	390	Identity:	211/390 - (54%)
Similarity:	278/390 - (71%)	Gaps:	5/390 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADVEKEPEKTIAEDLVVTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKVYK 65
            |:..:::.|:||||||||||||:.|:|.|:.|::::.......||..:|.:||..:.|||||::|
Mouse     1 MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFK 65

  Fly    66 KEKDLKKGIAFPTCLSVNNCVCHFSPAKNDADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAA 130
            |||::||||||||.:|||||||||||.|:|.||.||.||:||||||.|:|||||..|||.|:|.|
Mouse    66 KEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVA 130

  Fly   131 ADQKISGRQADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISESYKCKPIEGMLSHELKQFKI 195
            ...:::||:||||.||:...:|||||:|.|..|..:|:|..:::.|:.|.||||||||:|||..|
Mouse   131 QGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVI 195

  Fly   196 DGEKTIIQNPSEAQRKEHEKCTFETYEVYAIDVIVSTGEGVGREKDTKVSIYKKS-EENYMLKMK 259
            ||||||||||::.|:|:|||..||.:||||:||:||:|||..::...:.:|||:. .:.|.||||
Mouse   196 DGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMK 260

  Fly   260 ASRALLAEVKTKYGNMPFNIRSFEEETKARMGVVECVGHKMIEPFQVLYEKPSEIVAQFKHTVLL 324
            .|||..:||:.::..|||.:|:||:|.|||||||||..|::::||.|||||..|.|||||.||||
Mouse   261 TSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLL 325

  Fly   325 MPNGVNLVTGIPFEAENYVSEYSVAQEELKTLLAQPLGPVKGKGKGKKATAGAATKVETAPAVET 389
            ||||...:|..|||.:.|.||..|...|||.||.........|.|.||    |:..||.|.:.||
Mouse   326 MPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKK----ASKTVENATSGET 386

Fly 390 389
Mouse 387 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10576	NP_001286949.1	APP_MetAP	3..361	CDD:294199	200/358 (56%)
Pa2g4	NP_035249.1	crvDNA_42K	1..388	CDD:273105	211/390 (54%)
		Necessary for nucleolar localization. /evidence=ECO:0000250\|UniProtKB:Q9UQ80	2..48		19/45 (42%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9UQ80	46..54		2/7 (29%)
		Necessary for nucleolar localization. /evidence=ECO:0000250\|UniProtKB:Q9UQ80	301..394		44/90 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..394		11/33 (33%)
		Interaction with RNA. /evidence=ECO:0000269\|PubMed:17690690	361..375		4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1955
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4513
Inparanoid	1	1.050	422	1.000	Inparanoid score	I1762
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S1640
OMA	1	1.010	-	-		QHG54050
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002945
OrthoInspector	1	1.000	-	-		oto92565
orthoMCL	1	0.900	-	-		OOG6_101895
Panther	1	1.100	-	-	LDO	PTHR10804
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2037
SonicParanoid	1	1.000	-	-		X1946
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810