Protein Alignment Usp47 and USP48

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: NP_115612.4
• Gene: USP48 / 84196
• HGNCID: 18533
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 1093
• Identity: 235/1093 - (21%)
• Similarity: 365/1093 - (33%)
• Gaps: 388/1093 - (35%)

  Fly   395 YVGLVNQAMTCYLNSLLQALFMTPEFRNALYRW-------------EFDNDNEAKNIPYQLQKLF 446
            :|||.|...|||:|:.||..|:..|.|.|||..             :.:.|.|.:.|...||.||
Human    88 FVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEKDYEPQTICEHLQYLF 152

  Fly   447 LNLQTSPKAAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALE---HKFKNTKQANLISNLYE 508
            ..||.|.:..::.:...::.|.|:   .||.|.||..::....||   .|.||....|::...:.
Human   153 ALLQNSNRRYIDPSGFVKALGLDT---GQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNIVQQQFC 214

  Fly   509 GKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKC 573
            |:......|.:|..|......|.::.|.::      .:..:.:.:..|::.|.|:|:|:|.||.|
Human   215 GEYAYVTVCNQCGRESKLLSKFYELELNIQ------GHKQLTDCISEFLKEEKLEGDNRYFCENC 273

  Fly   574 KKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNS 638
            :.|.:|.:.:...|.|..|.|.|.||.||.||.|:.|||..:.|.:.|::..::...|
Human   274 QSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSEILDMEPYVEHKG------- 331

  Fly   639 QLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYL 703
                                                                         |.|:
Human   332 -------------------------------------------------------------GSYV 335

  Fly   704 YELFAIMIHSG-SASGGHYYAYIKDFDNNEWFCFNDQNVTSI----TQEDIQRSFGGPNGSY--- 760
            |||.|::||.| ||..|||.|::||..:.||:.|||:::..:    .|..|:.....|:.|.
Human   336 YELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRK 400

  Fly   761 --YSSAYTSSTNAYMLMYR-----------QVDAKRNELV-----------AKVADF-------- 793
              .......|.|||||:||           ||.|...|||           .::|:.
Human   401 PKCGKGTHCSRNAYMLVYRLQTQEKPNTTVQVPAFLQELVDRDNSKFEEWCIEMAEMRKQSVDKG 465

  Fly   794 ---PEHIKTLLPKLHS-----------------EEETRVSRLGRHITVT--DLALPDLYKPRVYF 836
               .|.:|.|..:|.:                 :|.|....:..|..:.  |...||
Human   466 KAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPIDNHACLCSHDKLHPD-------- 522

  Fly   837 YNPSLKKMKITRVYVSQSFNINLVLMSAY---EMLNVEQFAP---LSRCRLVAYNSSMDTIIQSL 895
               .:..||....|.:..|      .|.|   ..|.|:....   :.|||::...:.::...:::
Human   523 ---KISIMKRISEYAADIF------YSRYGGGPRLTVKALCKECVVERCRILRLKNQLNEDYKTV 578

  Fly   896 ESCTDPAL----------TELRAAQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMD 950
            .:....|:          :.||:.:..:|:.|     ::|:.:....||      |::.||:..|
Human   579 NNLLKAAVKGSDGFWVGKSSLRSWRQLALEQL-----DEQDGDAEQSNG------KMNGSTLNKD 632

  Fly   951 GPFLVYSAAREREASDVLRRSIAL-----RLHISEQQFLLATVRA------TVPKA--FVSYD-- 1000
                  .:..||:..:.|..:..:     .|.|||.:..|.:..|      ..|||  |.||.
Human   633 ------ESKEERKEEEELNFNEDILCPHGELCISENERRLVSKEAWSKLQQYFPKAPEFPSYKEC 691

  Fly  1001 ---------PHPTPEALQHLQNMANTQFKSITYFY--------LNVPNTDAATLEMLGVPTVESV 1048
                     .....|||..:  :||.|..|:...:        .|.|. |...|.::....||
Human   692 CSQCKILEREGEENEALHKM--IANEQKTSLPNLFQDKNRPCLSNWPE-DTDVLYIVSQFFVE-- 751

  Fly  1049 ECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRY--KRDLVEPMSQPSPS-----HG------HES 1100
                                        :||::  |.....|:|....|     ||      ...
Human   752 ----------------------------EWRKFVRKPTRCSPVSSVGNSALLCPHGGLMFTFASM 788

  Fly  1101 NSEDSSL------SDGDR-------------TLVETDNMAHRGGGDSQVSSTSH--SPQLSSPED 1144
            ..|||.|      |:...             |.:|.        ||...|.|.:  .|:| .||
Human   789 TKEDSKLIALIWPSEWQMIQKLFVVDHVIKITRIEV--------GDVNPSETQYISEPKL-CPE- 843

  Fly  1145 EAASHDAMMRVHAYCNGNGSYAAADVVDPLLLPTSTNHFFYATKV--------ECVDVVGTGSSS 1201
                    .|....|.....           |...|....|..||        :....:...||.
Human   844 --------CREGLLCQQQRD-----------LREYTQATIYVHKVVDNKKVMKDSAPELNVSSSE 889

  Fly  1202 GHQSDEEAQLRKP--------------TRAYKLLVGTHMRMGAFKKHIEQLIQVPAAHFKLQRKH 1252
            ..:..|||   ||              |:..|:   :|....|::|   |:|:....|.|
Human   890 TEEDKEEA---KPDGEKDPDFNQSNGGTKRQKI---SHQNYIAYQK---QVIRRSMRHRK----- 940

  Fly  1253 DNNLSNNQNNSLVHLIEGE-TLTVELGKTLEPDEFKAKI-HFLRLADIDNETS 1303
                           :.|| .|.|...:||:  |.|.:| |...:|..|...|
Human   941 ---------------VRGEKALLVSANQTLK--ELKIQIMHAFSVAPFDQNLS 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066
		peptidase_C19C	394..780	CDD:239124	109/421 (26%)
		USP47_C	1300..1534	CDD:466158	1/4 (25%)
USP48	NP_115612.4	Peptidase_C19L	90..419	CDD:239133	105/405 (26%)
		DUSP	484..554	CDD:399383	14/86 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	612..640		9/39 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	879..919		8/42 (19%)
		Ubl_USP48	939..1034	CDD:340493	14/60 (23%)