Protein Alignment Usp47 and USP26

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: NP_114113.1
• Gene: USP26 / 83844
• HGNCID: 13485
• Length: 913
• Species: Homo sapiens
• Alignment Length: 900
• Identity: 176/900 - (19%)
• Similarity: 289/900 - (32%)
• Gaps: 298/900 - (33%)

  Fly    77 VAGFEPQLKNHLIL-LPSGSWDGDVTKRFELPIKRVVVKK----------------------VMK 118
            :...|.:.|:.|:| ..||.:.   |.|....|:.||:|.                      :..
Human    27 IEAVERKKKDRLVLYFKSGKYS---TFRLSDNIQNVVLKSYRGNQNHLHLTLQNNNGLFIEGLSS 88

  Fly   119 SDGEKAK------------SPATGEKKKRVVGEKTKKKPASGSSSPSKAKTTSED-SLAKTSISS 170
            :|.|:.|            .|....|...|....|:|:....|......|::|:. .:||.|.:.
Human    89 TDAEQLKIFLDRVHQNEVQPPVRPGKGGSVFSSTTQKEINKTSFHKVDEKSSSKSFEIAKGSGTG 153

  Fly   171 --ESSPEKTSKIKTTAAKISKPGSEKAPRASPEECPELSTEINSKNTSSESPVAKKTAKVTSKPT 233
              :..|..|||:..|..::|:...:|..|.. ....|::.|...:|.|.|...:|..........
Human   154 VLQRMPLLTSKLTLTCGELSENQHKKRKRML-SSSSEMNEEFLKENNSVEYKKSKADCSRCVSYN 217

  Fly   234 LELLSPIKPSSPIKELDCEPVDTLSKQQLSEQLQLYPQGRNLISPVDDAPSDLFISDAEQLSDDD 298
            .|....:|.....|:|:||.                       |.:.:|..:.::        ||
Human   218 REKQLKLKELEENKKLECES-----------------------SCIMNATGNPYL--------DD 251

  Fly   299 LALGASASPTM-----LGPGYDYGAPTGDSDVEGVTGVTDPSTIGTDDGTYPALSNFYRRKYGGD 358
            :.|..:.:..|     |..||..|....|.                       |..|:
Human   252 IGLLQALTEKMVLVFLLQQGYSDGYTKWDK-----------------------LKLFF------- 286

  Fly   359 ELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGYV-GLVNQAMTCYLNSLLQALFMTPEFRN 422
                                          .|.|.... ||.|...|||:|::||:|...|.|.:
Human   287 ------------------------------ELFPEKICHGLPNLGNTCYMNAVLQSLLSIPSFAD 321

  Fly   423 ALYRWEF---------------------DNDN-EAKNIPYQLQKLFLNLQTSPKAAVETTDLTRS 465
            .|....|                     |..| |.|      :.|.|||:.:..||.|.
Human   322 DLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEIK------EMLLLNLKKAISAAAEI------ 374

  Fly   466 FGWDSTEAWQQHDIQELCRVMFDALEHKFK--NT--------------KQ------------ANL 502
            |..::     |:|..|......|.|:...:  ||              ||            ..:
Human   375 FHGNA-----QNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPV 434

  Fly   503 ISNLYEGKMNDYVKCLECNTE--KTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGN 565
            |:| :|.::...:.|..|...  ||..:.:|.|.||.|.....|   ||:.....|...|.|
Human   435 ITN-FELELLHSIACKACGQVILKTELNNYLSINLPQRIKAHPS---SIQSTFDLFFGAEEL--- 492

  Fly   566 NQYLCEKCKKKCDAHKGLH-FKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINR 629
             :|.|.||:.|...  |:| |...|.||.:||||:..:  ....:|.||     |.:.::.::..
Human   493 -EYKCAKCEHKTSV--GVHSFSRLPRILIVHLKRYSLN--EFCALKKND-----QEVIISKYLKV 547

  Fly   630 SGNSGEQNSQLNGTVDDCSTADSGSAMEDD------NLSSGVVTTA-SSSQHENDLNDEDEGIDM 687
            |.:..|      ||......::.|...:..      .::||.::.: .:::...|:.....|.|.
Human   548 SSHCNE------GTRPPLPLSEDGEITDFQLLKVIRKMTSGNISVSWPATKESKDILAPHIGSDK 606

  Fly   688 SSSTSK-------SAKQGSGPYL------YELFAIMIHSGSASG------GHYYAYIKDFDNNEW 733
            .|...|       ::::....||      .||.:  ::||..:.      .|...|::|....::
Human   607 ESEQKKGQTVFKGASRRQQQKYLGKNSKPNELES--VYSGDRAFIEKEPLAHLMTYLEDTSLCQF 669

  Fly   734 FCFNDQNVTS----ITQEDIQRSFGGPNGSYYSS-----AYTSSTNAYMLMYRQVDAKRNELVAK 789
            .....:..:|    :::.|.|.....|....|..     |:....|....:|...:.:..|...|
Human   670 HKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVAFDRIINPTKDLYEDKNIRIPERFQK 734

  Fly   790 VAD----------------------FPE-----HIKTLL--PKLHSEEETRVSRL 815
            |::                      ||:     |.|.||  .||:.::..|.|.|
Human   735 VSEQTQQCDGMRICEQAPQQALPQSFPKPGTQGHTKNLLRPTKLNLQKSNRNSLL 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066	30/141 (21%)
		peptidase_C19C	394..780	CDD:239124	101/474 (21%)
		USP47_C	1300..1534	CDD:466158
USP26	NP_114113.1	UCH_N	3..104	CDD:465227	15/79 (19%)
		UCH	296..564	CDD:425685	76/307 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..636		6/34 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	753..772		4/18 (22%)
		Peptidase_C19	<802..884	CDD:239072