Protein Alignment Usp47 and USP9X

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: NP_001397677.1
• Gene: USP9X / 8239
• HGNCID: 12632
• Length: 2575
• Species: Homo sapiens
• Alignment Length: 1287
• Identity: 258/1287 - (20%)
• Similarity: 441/1287 - (34%)
• Gaps: 452/1287 - (35%)

  Fly    55 LQPHDNKDLVNLNAL------------------------ESQLMY--EVAGFEPQLKNHLILLPS 93
            |.|.|:..:..|.|:                        .||::|  ||.        :.:|:|:
Human  1051 LMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVV--------YALLMPA 1107

  Fly    94 GSWDGDVTKRFE--------LPIKRVVVKK---VMKSDGE-------------KAKSPATGEKKK 134
            |:...|.:..|:        ||:...::.:   :..:|.|             |....|.|....
Human  1108 GAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHV 1172

  Fly   135 RVVGEKTKKKPASGSSSPSKAKTTSEDS--LAKTSISSESSPEKTSKIKTTAAKISKPGSEKAPR 197
            |.|.|.. :....|.:..::....:.|.  :.::::.|..:|.....::..:.::::..|::|.|
Human  1173 RAVAEAC-QPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASR 1236

  Fly   198 ASPEEC-----------------------PELSTEINSKNTSSESP------VAKKTAKVTSK-- 231
            ..|:.|                       .|..|:|..|..:...|      |..:..:|.:.
Human  1237 YMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCF 1301

  Fly   232 ---PT-LELLSPIKP-------------SSPIKELDCEP-------------------------V 254
               || |:.||..|.             |..::::..|.                         :
Human  1302 ALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVL 1366

  Fly   255 DTLSKQQLSEQLQLYPQGRNLISPVDDAPSDLFISDAEQLSDDDLALGASASPTMLGPGYDYGAP 319
            .:.::::.......:...|:|::...:  |::.:.:||.|.::::        ..|....|....
Human  1367 GSTARERAKHSGDYFTLLRHLLNYAYN--SNINVPNAEVLLNNEI--------DWLKRIRDDVKR 1421

  Fly   320 TGDSDV-----EGVTGVTDPST----------IG------------TDDGTYPALSNFYRRKYGG 357
            ||::.:     ||..|||....          ||            .||..:|| ||.|.:....
Human  1422 TGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPA-SNVYLQYMRN 1485

  Fly   358 DELRAWQRVNTTGAD--------------------------------FVSSATTETEAEARQASL 390
            .||.|.|.:...|:.                                ::.:|.|..||......|
Human  1486 GELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYL 1550

  Fly   391 ---GPR---GYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWE-----FDN--------DNEAK 436
               |||   |:|||.|...|||:||::|.|:|.|..||.:...|     .|:        |||:
Human  1551 PPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNES- 1614

  Fly   437 NIPYQLQKLFLNLQTSPKAAVETTD------------LTRSFG---------------WDSTEAW 474
            |:..:........|...|.|:..|:            |...||               |.....|
Human  1615 NVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLW 1679

  Fly   475 -------QQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLD 532
                   :|||..|....:.|:|:...|......::|.:..|...|...|..|......|::|..
Human  1680 GEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTT 1744

  Fly   533 IPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLK 597
            :.:.:|      .:.::.::|..:|:.:.|:|.|.|.||||.||.|..|.|..|..|.:|.:.||
Human  1745 LNVDIR------NHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLK 1803

  Fly   598 RFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLS 662
            |||:|::....||.||...||:.|::..:                      |....:.:|.||
Human  1804 RFDYDWERECAIKFNDYFEFPRELDMEPY----------------------TVAGVAKLEGDN-- 1844

  Fly   663 SGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYI-- 725
                           :|.|.:.|..|   .:|..:.:|...|.|..:::|||.|||||||:||
Human  1845 ---------------VNPESQLIQQS---EQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQ 1891

  Fly   726 ---KDFDNNEWFCFNDQNVTSITQEDIQ----RSFGGPNGSYYSSAYTSST------------NA 771
               .|.:.|.|:.|:|.:||....:|.:    :.||   |.|....:....            ||
Human  1892 RNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFG---GEYMGEVFDHMMKRMSYRRQKRWWNA 1953

  Fly   772 YMLMYRQVDA--KRNELVAKVADF-----PEHIKTLLPKLHSEEETRVSRLGRHITVTDLALPDL 829
            |:|.|.::|.  :.:||:..:::.     |..|  ::|          |.:.|.:.
Human  1954 YILFYERMDTIDQDDELIRYISELAITTRPHQI--IMP----------SAIERSVR--------- 1997

  Fly   830 YKPRVYF----------YNPSLKK-MKITRVYVSQSFNINLVLMSAYE--MLNVEQFAPL----- 876
             |..|.|          |...:|| :....||::.....:.:|..|.|  |::::..|..
Human  1998 -KQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARFLFTTG 2061

  Fly   877 ----------------SRCRLVAYNSSM-------------DTIIQSLESCTDPALTELRAAQNY 912
                            :.|.|:.::.::             :...:.|..|..   .|:|.|...
Human  2062 FHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPS---AEVRGAFAK 2123

  Fly   913 SLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAARER-EASDVLRRSI--AL 974
            .:.|:..:..:|....                |..|..||   .|.|.:. ..||.|.|::  .|
Human  2124 LIVFIAHFSLQDGPCP----------------SPFASPGP---SSQAYDNLSLSDHLLRAVLNLL 2169

  Fly   975 RLHISE-----QQFL--------------LATVRATVPKAF--VSYDPHPTP 1005
            |..:||     ||:.              ...::.:||..|  ||.|..|.|
Human  2170 RREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGP 2221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066	30/189 (16%)
		peptidase_C19C	394..780	CDD:239124	118/453 (26%)
		USP47_C	1300..1534	CDD:466158
USP9X	NP_001397677.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		Ubl1_cv_Nsp3_N-like	<905..969	CDD:475130
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..1004
		peptidase_C19C	1560..1963	CDD:239124	118/454 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1597..1626		5/29 (17%)
		DUF3517	2102..2481	CDD:463438	31/142 (22%)