Protein Alignment Usp47 and USP7

DIOPT Version :9

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_016879141.1
• Gene: USP7 / 7874
• HGNCID: 12630
• Length: 1113
• Species: Homo sapiens
• Alignment Length: 1150
• Identity: 259/1150 - (22%)
• Similarity: 427/1150 - (37%)
• Gaps: 376/1150 - (32%)

  Fly   350 FYRRK--YGGDELRAWQRVNTTGADFV--SSATTE--TEAEARQA----SLGPRGYVGLVNQAMT 404
            |:.::  :|.....||..|......|:  ...|.|  .:|:|...    |....|||||.||..|
Human   158 FFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGAT 222

  Fly   405 CYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFGWD 469
            ||:|||||.||.|.:.|.|:|....:.|:.:|::|..||::|..||.|.| .|.|..||:||||:
Human   223 CYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK-PVGTKKLTKSFGWE 286

  Fly   470 STEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIP 534
            :.:::.|||:||||||:.|.:|:|.|.|.....|..|:.|||..|::|.|.:....|.:.:.||.
Human   287 TLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQ 351

  Fly   535 LPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRF 599
            |.::  |..:.:.|..:    :|..|.|||:|:|...:...: :|.||:.|.:.|.:|.|.|.||
Human   352 LSIK--GKKNIFESFVD----YVAVEQLDGDNKYDAGEHGLQ-EAEKGVKFLTLPPVLHLQLMRF 409

  Fly   600 DFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSG 664
            .:|.||...||:|||..||:.|.|:.|:.::
Human   410 MYDPQTDQNIKINDRFEFPEQLPLDEFLQKT---------------------------------- 440

  Fly   665 VVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKDFD 729
                        |..|                    |..|.|.|:::|||...||||..|:....
Human   441 ------------DPKD--------------------PANYILHAVLVHSGDNHGGHYVVYLNPKG 473

  Fly   730 NNEWFCFNDQNVTSITQED-IQRSFGGPNGSYYSSAYTSSTNAYMLMYRQVDAKRNELVAKVA-- 791
            :.:|..|:|..|:..|:|: |:.::||.:...   :....||||||:|.: ::|.:|::..|.
Human   474 DGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDL---SVRHCTNAYMLVYIR-ESKLSEVLQAVTDH 534

  Fly   792 DFPEHIKTLLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKMKITRVYVSQSFN 856
            |.|:.:...|     :||.|:....|                        |:.:...:|:    .
Human   535 DIPQQLVERL-----QEEKRIEAQKR------------------------KERQEAHLYM----Q 566

  Fly   857 INLVLMSAY------EMLNVEQFAPLSRCRLVAY-------NSSMDTIIQSLESCTDPALTELRA 908
            :.:|....:      :|.:.|:         |.|       |||:...:|||.........::|.
Human   567 VQIVAEDQFCGHQGNDMYDEEK---------VKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRL 622

  Fly   909 AQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREASDVLRRSIA 973
                   :.::.|:...:......|........::||.  .:.|:.::....:.|
Human   623 -------WPMQARSNGTKRPAMLDNEADGNKTMIELSD--NENPWTIFLETVDPE---------- 668

  Fly   974 LRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYF-YLNVPNTDAATL 1037
                       ||...||:||....:|       :.....|.:.:.:|:.|. ::..| ......
Human   669 -----------LAASGATLPKFDKDHD-------VMLFLKMYDPKTRSLNYCGHIYTP-ISCKIR 714

  Fly  1038 EMLGVPTVESVECASGGDVVDAAMM--NGVAPGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGHES 1100
            ::|      .|.|...|.:.|.:::  ..|.|.......|||
Human   715 DLL------PVMCDRAGFIQDTSLILYEEVKPNLTERIQDYD----------------------- 750

  Fly  1101 NSEDSSLS---DGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMMRVHAYCNGN 1162
            .|.|.:|.   |||..:.:.|:                      ||::.:.
Human   751 VSLDKALDELMDGDIIVFQKDD----------------------PENDNSE-------------- 779

  Fly  1163 GSYAAADVVDPLLLPTSTNHF--FYATKVECVDVVGTGSSSGHQSDEEAQLRKPTRAYKLLVGTH 1225
                         |||:..:|  .|    ..|||:....:..:...             .:|...
Human   780 -------------LPTAKEYFRDLY----HRVDVIFCDKTIPNDPG-------------FVVTLS 814

  Fly  1226 MRMGAFK--KHIEQ-------LIQVPAAHFKLQRKHDNNLSNNQNNSLVHLIEGETLTVELGKTL 1281
            .||..|:  |.:.|       |:|    .||.|...|     ...|.|.|..|| ||. :|.:..
Human   815 NRMNYFQVAKTVAQRLNTDPMLLQ----FFKSQGYRD-----GPGNPLRHNYEG-TLR-DLLQFF 868

  Fly  1282 EPDEFKAKIHF----LRLADIDNETSKLPCVCEWVYNANTTAEQAKKELVAKLHRIDAKYATLSV 1342
            :|.:.| |:::    :::.|.:|..| ..|
Human   869 KPRQPK-KLYYQQLKMKITDFENRRS-FKC----------------------------------- 896

  Fly  1343 QNCRIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPK-DDSLTLFVRRWCPAK 1406
                |||..     :...::.|||.|....:  ..:::||::.|:...| ...|.|
Human   897 ----IWLNS-----QFREEEITLYPDKHGCV--RDLLEECKKAVELGEKASGKLRL--------- 941

  Fly  1407 LEFGKFQEITLDQDSEIRLSLS-------QISDIPIDKLSYMKLN 1444
            ||...::.|.:.|:.|:...||       :|.:||:|::...|.|
Human   942 LEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKEN 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	127/386 (33%)
		UCH	395..776	CDD:278850	125/381 (33%)
USP7	XP_016879141.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820