DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and usp9

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	XP_005167793.1	Gene:	usp9 / 568683	ZFINID:	ZDB-GENE-061019-1	Length:	2594	Species:	Danio rerio

Alignment Length:	853	Identity:	189/853 - (22%)
Similarity:	311/853 - (36%)	Gaps:	248/853 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 ALGASASPTMLGPGYDYGAPTGDSDVEGVTGVTDPSTIGTDDGTYPALSNFYRRKYGGDELRAWQ 364
            |:...::|..:..|::.........|..:..:.|            .|::.|  ..|.:.|..|:
Zfish  1492 AIPVCSTPATINAGFELLVALAIGCVRNLKQIVD------------TLTDMY--YLGCEPLTEWE 1542

  Fly   365 RVNTTGADFVSSATTETEAEARQASLGPR---GYVGLVNQAMTCYLNSLLQALFMTPEFRNAL-- 424
            .:                     ..:|||   |:|||.|...|||:||::|.|:|.|..||.:
Zfish  1543 YL---------------------PPVGPRPTKGFVGLKNAGATCYMNSVIQQLYMIPPIRNGILA 1586

  Fly   425 --------------------------------YRWEFDN--------DNEAKNIPY--QLQKLFL 447
                                            |:.:||:        |.:..||..  |||.:|.
Zfish  1587 IEGTGSDVDDDMSGDEKQDNESNVDPRDEVFGYQHQFDDKPSLSKSEDRKEYNIGVLRQLQVIFG 1651

  Fly   448 NLQTSPKAAVETTDLTRSFGWDSTEAW-------QQHDIQELCRVMFDALEHKFKNTKQANLISN 505
            :|.:|.....    :.|.| |.....|       :|||..|....:.|:|:...|......::|.
Zfish  1652 HLASSRLQYY----VPRGF-WKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSK 1711

  Fly   506 LYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLC 570
            :..|...|...|..|......|::|..:.:.:|      .:.::.:::..:|:.:.|:|.|.|.|
Zfish  1712 VLGGSFADQKICQGCPHRYECEESFTTLNVDIR------NHQNLLDSMEQYVKGDLLEGANAYHC 1770

  Fly   571 EKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGE 635
            |||.||.|..|.|..|..|.:|.:.|||||:|::....||.||...||:.|::..:
Zfish  1771 EKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPY--------- 1826

  Fly   636 QNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQH-EN-----DLNDEDEGIDMSSSTSKS 694
                   ||                  :||.....|..| ||     ..|:..|.....||.
Zfish  1827 -------TV------------------AGVAKLEGSDVHPENQQQVIQQNEPSEPEPPCSSR--- 1863

  Fly   695 AKQGSGPYLYELFAIMIHSGSASGGHYYAYI-------KDFDNNEWFCFNDQNVTSITQEDIQ-- 750
                     |.|..:::|||.|||||||:||       .:.:.|.|:.|:|.:||....:|.:
Zfish  1864 ---------YRLVGVLVHSGQASGGHYYSYIIQRNGSGGEGERNRWYKFDDGDVTECKMDDDEEM 1919

  Fly   751 --RSFGGPNGSYYSSAYTSST------------NAYMLMYRQVDA--KRNELVAKVADFPEHIKT 799
              :.||   |.|....:....            |||:|.|.::|.  |.:|||..:.:.....|.
Zfish  1920 KNQCFG---GEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTLDKDSELVKYITELTVSSKP 1981

  Fly   800 LLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKMKITRVY---VSQSFNINLVL 861
            ...|:.|..|..|.                 |..|.|.:   .:|:.:..|   :.:....|.|.
Zfish  1982 HQVKMPSAIERSVR-----------------KQNVQFMH---NRMQYSLEYFQFIRKLLTCNSVY 2026

  Fly   862 MSA-----YEMLNVEQFAPLSRCRLVA---YNSSMDT--IIQSLES-CTDPALTELRAAQN---- 911
            :::     :.:...|:.|.:| .:|.|   :::...|  |::...| ..|.....||.::|
Zfish  2027 LNSPPGQDHLLPEAEEMAMIS-IQLAARFLFSTGFHTKKIVRGPASDWYDALCILLRHSKNVRYW 2090

  Fly   912 YSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMA----MDG--PFLVYSAAREREASDVLRR 970
            ::.:.|..|.....|:.:..|:......|...:..:|    .||  |..:.|.....:..|
Zfish  2091 FAHNVLFAYPNRFSEYLLECPSAEVRGAFSKLIVFIAHFSLQDGPCPTPIASPGPSSQGCD---- 2151

  Fly   971 SIALRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYFYLNVPNTDAA 1035
                .|.:||..|          :|.::.......|..:|||     |:.::...|.|:...:..
Zfish  2152 ----NLSLSEHLF----------RAVLNLLRREVSEHGRHLQ-----QYFNLFVMYANLGLAEKT 2197

  Fly  1036 TLEMLGVP 1043
            .|..||||
Zfish  2198 QLLKLGVP 2205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	119/465 (26%)
		UCH	395..776	CDD:278850	117/460 (25%)
usp9	XP_005167793.1	peptidase_C19C	1554..1961	CDD:239124	119/466 (26%)
usp9	XP_005167793.1	UCH	1556..1956	CDD:278850	117/459 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910