DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and usp28

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	XP_001920096.1	Gene:	usp28 / 567050	ZFINID:	ZDB-GENE-041008-142	Length:	1163	Species:	Danio rerio

Alignment Length:	1203	Identity:	240/1203 - (19%)
Similarity:	405/1203 - (33%)	Gaps:	395/1203 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 ELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGY-------VGLVNQAMTCYLNSLLQALFM 416
            |.|...|.....|:..::.......|....|..|..:       ||:.|...||:.::::|:||.
Zfish   106 ERRELHRALEVSAEENAARIKRKRCEGSGESCSPAEWIRQEDCPVGIRNVGNTCWFSAVIQSLFH 170

  Fly   417 TPEFRNALYRW--------EFDNDNEAKNIPY--QLQKLFLNLQTS------PKAAVETTDLTRS 465
            .|.||..:..:        :..:.:|.:||.:  :|:.||..:..|      |.||||   |.|.
Zfish   171 LPVFRRLVLNYCLSERVLEKCKSHSEKRNIAFMQELRCLFALMVGSNRRFVDPSAAVE---LLRD 232

  Fly   466 FGWDSTEAWQQHDIQELCRVMFDALEHKFK--------NTKQANLISNLYEGKMNDYVKCLECNT 522
             .:.::||  |.|:.|....:.|.||..|:        ..||.|.:..|:.|   .:|      .
Zfish   233 -AFRTSEA--QQDVSEFTHKLLDWLEDAFQLAANGTNPEDKQNNPMVQLFYG---TFV------A 285

  Fly   523 EKTRE-------DTFLDIPLPVRPFGSSSAYGSIEEALR-AFVQPETLDGNNQYLCEKCKKKCDA 579
            |:..|       :.|...||.|      :.:.:::|.|. |.|:.|.
Zfish   286 ERLHEGEIVSNIEQFGQYPLQV------NGFNNLDECLEGAMVEGEI------------------ 326

  Fly   580 HKGLH------------FKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRS-- 630
             :.||            |...|.:||..|.||:|:.......|::.::.|||.:.::.:::::
Zfish   327 -ESLHSDQTLSSGQERWFSKLPPVLTFELSRFEFNQSLGRPEKIHKKLEFPQVIYMDRYLHKNVN 390

  Fly   631 ---GNSGE----------QNSQLNGTVD------------------------------------- 645
               |..||          ...:|.|..:
Zfish   391 QTHGRRGEVKRLKDQLTLLQQKLEGYKNYGSGPAKYPLADMLQYVLEFATTKPTNPGSPVPTNPP 455

  Fly   646 ---DCSTADSGSAMEDDNLS---SGVVTTASS------------------------SQHENDLN- 679
               |.|:.||.....||..|   ||...||:.                        |..|.:|:
Zfish   456 ISTDPSSGDSSQTEADDAGSSDGSGCPPTATQRTPIHKPFTQCRPPMEVPVQPAPHSVSEEELHF 520

  Fly   680 -----------DEDEGIDMSSSTSKSAKQGSGPYL--------YELFAIMIHSGSASGGHYYAYI 725
                       .|:...::.:|..|.::...|.|.        |.|.|:::|.|.||.|||:|||
Zfish   521 IRSCLQRWRAEVENTISELKASIDKVSQALEGMYSDNSLCQVPYRLHAVLVHEGQASAGHYWAYI 585

  Fly   726 KDFDNNEWFCFNDQNVTSITQEDIQR-SFGG-PNGSYYSSAYTSSTNAYMLMYRQVDAKRNELVA 788
            .|.....|..:||..|...|.|::.| |:|| .|.|.|...|.:....| |:....|.:..:::.
Zfish   586 YDHAQRRWLKYNDVLVAESTWEELVRDSYGGMTNASAYCLMYINDNLPY-LIAEDTDVETGQVLK 649

  Fly   789 KVADFPEHIKTLL--------PKLHSEEE-------------TRVSRLGRHITVTDLALPDLYKP 832
            .:...|..::..:        .:|...||             |..|      |.|:..:|:  :|
Zfish   650 GMDSLPSVLRRYVREDNRWFQQELREWEEQFCQAQRDETPVQTNTS------TSTEQPVPE--EP 706

  Fly   833 RVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDTIIQSLES 897
            :    ||..:..:                    |..|.:...|.|           |:....::.
Zfish   707 Q----NPEPEPTQ--------------------EQTNEDTEEPPS-----------DSTPAPVQE 736

  Fly   898 CTDPALTELRAAQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAARER 962
            ..:|.::.|..         :...|.:.|.::   ||           :...|.|        |.
Zfish   737 SEEPTVSPLNP---------ISPEASENEEQI---NG-----------SQTQDQP--------EE 770

  Fly   963 EASD----VLRRSIALRLHISEQQFLLATVRATVPK--AFVSYDPHPTPEALQHLQNMA---NTQ 1018
            |..|    |....:.....:.||        .|.|:  |....|....|||....::.|   |||
Zfish   771 EKPDQSQSVSAGELETETEVEEQ--------VTNPEGGAEAEVDAQTDPEASSTEESTAEDTNTQ 827

  Fly  1019 FKSITYFYLNVPN---------TDAATLEMLGVPTVESV--ECASGGDVVDAAMMNGVAPGHMSS 1072
            .:: ....:.:||         .|....||:..|.::.|  ..|...:..|   .:|...|.:.:
Zfish   828 PEN-EVSEVEIPNVGKILVRSDVDGYNEEMMLTPAMQGVIFAIAKAREAFD---KDGPEAGLIKA 888

  Fly  1073 SNDYDWRRYKRDLVEPMSQPSPSHGH------ESNSEDSSLSDGDRTLVETDNMAHRGGGDSQVS 1131
            .::...|.|:....|...|..|...|      ::.:.:..:   :|||:|.....:....|..||
Zfish   889 FHEEYLRLYELSQEETTPQQDPRLQHVLVYLFQNKAPERVI---ERTLLEQFGDRNLSFDDRAVS 950

  Fly  1132 ---STSHSPQLSSPEDEAASHDAMMRVHAYCNGNGSYAAADVVDPLLLPTSTNHFFYATKVECVD 1193
               ......:|..|||        |.:..|...:..|:....|...|| |....:......|.:.
Zfish   951 IMREARSKLRLIRPED--------MDMDEYLQWHDDYSMFKTVFAYLL-TGLEQYQNGKIREALI 1006

  Fly  1194 VVGTGSSSGHQSDEEAQLRKPTR--AYKLLVGTHMRMGAFKKHIEQLIQVPAAHFKLQRKHD--- 1253
            .:    :..|| |..|.|.|..|  ..:.|:..:.|     |.:::|.:..|..||.|.:.|
Zfish  1007 YL----AHAHQ-DNSALLTKGERKGVDQSLIALYRR-----KCLKELNEKAATLFKSQDESDVTE 1061

  Fly  1254 -NNLSNNQNNSLVHLIEGETLTVE---------------LGKTLEPDEFKAKI-HFL-RLADIDN 1300
             .:|.|......:||:..::::.|               ||:.:: |..:.|: .|| |:.|...
Zfish  1062 GESLMNECVIPCMHLMVRDSVSQEDLDVIELIRNCWCSYLGQDMD-DSLQEKLSEFLPRVLDCSA 1125

  Fly  1301 E-----------------TSKLPCVCEWVYNAN 1316
            |                 .|:|..|.|.:::|:
Zfish  1126 ERVVLKEPPKVRKSPHDLCSRLAAVMESIHSAS 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	119/540 (22%)
		UCH	395..776	CDD:278850	119/535 (22%)
usp28	XP_001920096.1	UBA_UBP25_like	19..55	CDD:270462
		UCH	149..>393	CDD:278850	65/283 (23%)
		Peptidase_C19I	151..628	CDD:239130	115/516 (22%)
		Peptidase_C19	151..>254	CDD:271592	30/108 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900