Protein Alignment Usp47 and usp34

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_009292973.3
• Gene: usp34 / 562779
• ZFINID: ZDB-GENE-100210-6
• Length: 3624
• Species: Danio rerio
• Alignment Length: 731
• Identity: 159/731 - (21%)
• Similarity: 271/731 - (37%)
• Gaps: 200/731 - (27%)

  Fly   380 ETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQK 444
            :..||.|        :|||.|...||||.|.:|.|:|.||.|.|::..::..|.:.|....:|||
Zfish  1944 DVRAECR--------FVGLTNLGATCYLASTIQQLYMIPEARQAVFTAKYSEDIKHKTTLLELQK 2000

  Fly   445 LFLNLQTSPKAAVETTDLTRSFGWDS--TEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLY 507
            :|..|..|.:.|.......:::..|.  ....:|.|:.|....:...:|...::.|  |.:..|:
Zfish  2001 MFTYLMESERKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLITKIEEMSQDLK--NTVKTLF 2063

  Fly   508 EGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEK 572
            .|.:.:.|..|:|:......:.|..:...|...  .:.|.|::|.    ...:||:|:|.|.|.:
Zfish  2064 GGVITNNVVSLDCDHVSQTAEEFYTVRCQVADM--KNIYESLDEV----TIKDTLEGDNMYTCSQ 2122

  Fly   573 CKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQN 637
            |.||..|.|...||..|.||:.:..|:.|:..||.:.|:|...:||..|::..:
Zfish  2123 CGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPY----------- 2176

  Fly   638 SQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPY 702
                              .||..::.|               |..||. ...|.:|.|:.    |
Zfish  2177 ------------------TEDFLMAKG---------------DRKEGF-RDDSDAKVAES----Y 2203

  Fly   703 LYELFAIMIHSGSASGGHYYAYIKD------FDNNEWFCFNDQNVTSITQEDI-QRSFGGP---- 756
            .|:|..:.:|:|:|.|||||::|:|      :.||:|:.|||..|.......: ...|||.
Zfish  2204 EYDLIGVTVHTGTADGGHYYSFIRDIINPHAYRNNKWYLFNDAEVKPFDSAQLASECFGGEMTTK 2268

  Fly   757 -----NGSYYSSAYTSSTNAYMLMYRQVDAKRNELVAKVADFPEHIKTLLPKLHSEEETRVSRLG 816
                 ...:...::..:.:||||.|::|:.                         |||.     |
Zfish  2269 TYDSVTDKFMDFSFEKTHSAYMLFYKRVEV-------------------------EEEN-----G 2303

  Fly   817 RHITVTDLALPDLYKPRVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRL 881
            :.... |:: |||.:   :.::.:::.::...::....|.....|.|:......:   |.|...:
Zfish  2304 KDFNF-DIS-PDLLE---WIWHDNMQFLQDKNIFEHTYFGFMWQLCSSIPSTLPD---PKSVSLM 2360

  Fly   882 VAYNSS---MDTIIQSLESCTDPALTELRAAQ----NYSLDFLLEYRAED----QEFEVYPPNGI 935
            .|..|:   ::|.|.|.|..|.....||...|    ..:.::.|:..|:|    .:..:..||.|
Zfish  2361 TAKLSTSFVLETFIHSKEKPTMLQWIELLTKQFNNSQAACEWFLDQMADDNWWPMQILIKCPNQI 2425

  Fly   936 TWYVFK----------------------VDLSTMAMDGPFLVYSAAREREASDVLRRSIALRLHI 978
            ...:|:                      ::..:..||||           ..|:..||...|.
Zfish  2426 VRQMFQRLCIHVIQRLRPVHAHLYLQPGMEDGSDDMDGP-----------VEDIGSRSCVTRF-- 2477

  Fly   979 SEQQFLLATVRATVPKAFVSYDPHPTPEALQHL------------------QNMANTQFKSI-TY 1024
                          .|..:|...|......:||                  |.:.:.|..|| .:
Zfish  2478 --------------VKTLLSIMEHGVKPHSKHLTEYFAFLYEFAKMGEEESQFLLSLQAISIMVH 2528

  Fly  1025 FYLNVPNTDAATLEML 1040
            ||:.....:...:|:|
Zfish  2529 FYMGTKGPENPQVEVL 2544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066
		peptidase_C19C	394..780	CDD:239124	104/403 (26%)
		USP47_C	1300..1534	CDD:466158
usp34	XP_009292973.3	peptidase_C19C	1950..2297	CDD:239124	105/411 (26%)
		DUF3517	2416..2749	CDD:463438	25/156 (16%)