Protein Alignment Usp47 and usp7

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_009297739.4
• Gene: usp7 / 553758
• ZFINID: ZDB-GENE-030131-3656
• Length: 1130
• Species: Danio rerio
• Alignment Length: 1159
• Identity: 265/1159 - (22%)
• Similarity: 431/1159 - (37%)
• Gaps: 387/1159 - (33%)

  Fly   350 FYRRK--YGGDELRAWQRVNTTGADFV--SSATTE--TEAEARQA----SLGPRGYVGLVNQAMT 404
            |:.::  :|.....:|..|......||  ...|.|  .:|:|...    |....|||||.||..|
Zfish   179 FFHKENDWGFSNFMSWSDVTDPERGFVEDDKVTFEVYVQADAPHGVAWDSKKHTGYVGLKNQGAT 243

  Fly   405 CYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFGWD 469
            ||:|||||.||.|.:.|.|:|....:.|:.:|::|..||::|..||.|.| .|.|..||:||||:
Zfish   244 CYMNSLLQTLFFTNQLRRAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK-PVGTKKLTKSFGWE 307

  Fly   470 STEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIP 534
            :.:::.|||:||||||:.|.:|:|.|.|.....|..|:.|||..|::|...:....|.:.:.||.
Zfish   308 TLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKHVDYRSERIEDYYDIQ 372

  Fly   535 LPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRF 599
            |.::  |..:.:    |:.:.:|..|.|||:|:|...:...: :|.||:.|.:||.||.|.|.||
Zfish   373 LSIK--GKKNIF----ESFKDYVAVEQLDGDNKYDAGEHGLQ-EAEKGVKFLTFPPILHLQLMRF 430

  Fly   600 DFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSG 664
            .:|.||...||:|||..||:.|.|:.|:.:.
Zfish   431 MYDPQTDQNIKINDRFEFPEQLPLDEFLQKP---------------------------------- 461

  Fly   665 VVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKDFD 729
                        |:.|                    |..|.|.|:::|||...||||..|:....
Zfish   462 ------------DVKD--------------------PANYILHAVLVHSGDNHGGHYVVYLNPKG 494

  Fly   730 NNE-------WFCFNDQNVTSITQED-IQRSFGGPNGSYYSSAYTSSTNAYMLMYRQVDAKRNEL 786
            :.:       |..|:|..|:..|:|: .:.::||.:...   :....||||||:|.: ::|.:|:
Zfish   495 DGKVSVTAPIWCKFDDDVVSRCTKEEATEHNYGGHDDDL---SVRHCTNAYMLVYIR-ESKLSEV 555

  Fly   787 VAKVA--DFPEH-IKTLLPKLHSEEETRVSRLGRHI-----TVTDLAL-----PDLYKPRVYFYN 838
            :..|.  |.|:. ::.|..:...|.:.|..|...|:     .||:...     .|:|..
Zfish   556 LQPVTDMDIPQQLVERLQEEKRVEAQKRKERQEAHLYMQVQMVTEDQFCGHQGNDMYDE------ 614

  Fly   839 PSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFA--PLSRCRLVAYNSSMDTIIQSLESCTD- 900
               :|:|.|...|.:|..:      |..:.|:.|..  |..:.||..        :|:..:.|.
Zfish   615 ---EKVKYTVFKVLKSSTL------AEFVQNLSQTMGFPQDQMRLWP--------MQARSNGTKR 662

  Fly   901 PALTELRAAQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREAS 965
            ||:.:..|..|.|:                           :|||.  .:.|:.::....:.|
Zfish   663 PAMLDYEADCNKSM---------------------------IDLSD--NENPWTIFLETVDPE-- 696

  Fly   966 DVLRRSIALRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYF-YLNV 1029
                               :|...||:||....:|       :.....|.:.:.:|:.|. ::..
Zfish   697 -------------------MAASGATLPKFDKDHD-------VMLFLKMYDPKTRSLNYCGHIYT 735

  Fly  1030 PNTDAATLEMLGVPTVESVECASGG--DVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEPMSQP 1092
            | ......::|      .|.|...|  ......:...|.|.......|||
Zfish   736 P-ISCKIRDLL------PVMCERAGFQQGTSLILYEEVKPNLTERIQDYD--------------- 778

  Fly  1093 SPSHGHESNSEDSSLS---DGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMMR 1154
                    .|.|.:|.   |||..:.:.|:                      ||::.:.
Zfish   779 --------VSLDKALDELMDGDIIVFQKDD----------------------PENDTSE------ 807

  Fly  1155 VHAYCNGNGSYAAADVVDPLLLPTSTNHF--FYATKVECVDVVGTGSSSGHQSDEEAQLRKPTRA 1217
                                 |||:.::|  .|    ..|||:....:..:...
Zfish   808 ---------------------LPTAKDYFRDLY----HRVDVIFCDKTIHNDPG----------- 836

  Fly  1218 YKLLVGTHMRMGAFK--KHIEQ-------LIQVPAAHFKLQRKHDNNLSNNQNNSLVHLIEGETL 1273
              .:|....||..|:  |.:.|       |:|    .||.|...|     ...|.|.|..|| ||
Zfish   837 --FVVTLSNRMNYFQVAKTVAQRLNTDPMLLQ----FFKSQGYRD-----GPGNPLRHNYEG-TL 889

  Fly  1274 TVELGKTLEPDEFKAKIHF----LRLADIDNETSKLPCVCEWVYNANTTAEQAKKELVAKLHRID 1334
            . :|.:..:|.:.| |:::    :::.|.:|..|         :.|
Zfish   890 R-DLLQFFKPRQPK-KLYYQQLKMKITDFENRRS---------FKA------------------- 924

  Fly  1335 AKYATLSVQNCRIWLKGGRIPIKILSDDE-TLYCDMRSSIAAEFIVQECEEEVDPQPK-DDSLTL 1397
                        |||.      .:..::| |||.|....:  ..:::||::.|:...| .:.|.|
Zfish   925 ------------IWLN------SMFREEEITLYPDKHGCV--RDLLEECKKAVELSDKGSEKLRL 969

  Fly  1398 FVRRWCPAKLEFGKFQEITLDQDSEIRLSLS-------QISDIPIDKLSYMKLN 1444
                     ||...::.|.:.|:.|:...||       :|.:||:|::...|.|
Zfish   970 ---------LEIVSYKIIGVHQEDELLECLSPAASRTFRIEEIPLDQVDLDKEN 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066
		peptidase_C19C	394..780	CDD:239124	127/393 (32%)
		USP47_C	1300..1534	CDD:466158	30/154 (19%)
usp7	XP_009297739.4	None