DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and USP40

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	NP_001369225.1	Gene:	USP40 / 55230	HGNCID:	20069	Length:	1256	Species:	Homo sapiens

Alignment Length:	1406	Identity:	300/1406 - (21%)
Similarity:	475/1406 - (33%)	Gaps:	522/1406 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 YPALSNFYRRKYG-GDELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGYV---GLVNQAMT 404
            |..:||   .:|| |.:|:                |...|..|      ||.:.   |:.||..|
Human    10 YSTVSN---NQYGKGKKLK----------------TKALEPPA------PREFTNLSGIRNQGGT 49

  Fly   405 CYLNSLLQALFMTPEFRNALYRWE------FDN----DNEAKNIPYQLQKLFLNLQTSPKAAVET 459
            ||||||||.|..|||||.||:...      |::    |.:.:.||.|||:||..|....:.|..|
Human    50 CYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAAST 114

  Fly   460 TDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEK 524
            .|||.||||.|.|..:|||:|||.|::|.|||.....|...:||..||.|.:.:.:.|.||....
Human   115 ADLTDSFGWTSNEEMRQHDVQELNRILFSALETSLVGTSGHDLIYRLYHGTIVNQIVCKECKNVS 179

  Fly   525 TREDTFLDIPLPVRPFGSSSAYGSIEEAL-RAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSF 588
            .|::.|||:.:.|:      ....:|:|| ..:|:.|..|.:|.|.|..|.:...|.|....:..
Human   180 ERQEDFLDLTVAVK------NVSGLEDALWNMYVEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKL 238

  Fly   589 PYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSG 653
            |..||:.|.||:||:....|.|.....|||..:||..|..:|
Human   239 PPFLTVSLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQS----------------------- 280

  Fly   654 SAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASG 718
                                   :|:|.:                   |:|:||:::||.|...|
Human   281 -----------------------ELDDLE-------------------YIYDLFSVIIHKGGCYG 303

  Fly   719 GHYYAYIKDFDN-NEWFCFNDQNVTSITQEDIQRSFGGPNGSYYSSAYTSSTNAYMLMYRQVDAK 782
            |||:.||||.|: ..|....:::...:..:|:|..                        .::|
Human   304 GHYHVYIKDVDHLGNWQFQEEKSKPDVNLKDLQSE------------------------EEID-- 342

  Fly   783 RNELVAKVADFPEHIKTLLPKLHSEEETR---VSRLGRHITVTDLALPDLYKPRVYFYNPSLKKM 844
                         |...:|..:..|||..   |.:||:.:                     |||:
Human   343 -------------HPLMILKAILLEEENNLIPVDQLGQKL---------------------LKKI 373

  Fly   845 KITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDTIIQSLESCTDPALTELRAA 909
            .|       |:|      ..|.    :|..||   |......|...::.|.||       .:|..
Human   374 GI-------SWN------KKYR----KQHGPL---RKFLQLHSQIFLLSSDES-------TVRLL 411

  Fly   910 QNYSLDFLLEYRAEDQE-FEVYPP------NGIT---WYVFKVDLSTMAMDGPFLVYSAAREREA 964
            :|.||....:::..||: |::.||      |.|:   |:    |::               :.:.
Human   412 KNSSLQAESDFQRNDQQIFKMLPPESPGLNNSISCPHWF----DIN---------------DSKV 457

  Fly   965 SDVLRRSIALRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYFYLNV 1029
            ..:..:.|..:....|..::|...::.:.:         .|||      .||.:: .:....||
Human   458 QPIREKDIEQQFQGKESAYMLFYRKSQLQR---------PPEA------RANPRY-GVPCHLLN- 505

  Fly  1030 PNTDAATLEMLGVPTVESVECASGGDVVDAAM--------MNGVAPGHMSSSND-----YDWRRY 1081
             ..|||.:|:    ..:..||.|..:..:..:        .||.....:|.:..     :|.|:.
Human   506 -EMDAANIEL----QTKRAECDSANNTFELHLHLGPQYHFFNGALHPVVSQTESVWDLTFDKRKT 565

  Fly  1082 KRDLVEPMSQ-----------------PSPSHGHESNSEDSSLSDGDRTLVETD----------N 1119
            ..||.:.:.|                 |:..|.::      ||...:.||.||:          |
Human   566 LGDLRQSIFQLLEFWEGDMVLSVAKLVPAGLHIYQ------SLGGDELTLCETEIADGEDIFVWN 624

  Fly  1120 MAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMMRVHAYCNGNGSYAAADVVDPLLLPTSTNHFF 1184
            ....||...| :.....|.|            :..:|...:.:|......:..|.:.|.:.....
Human   625 GVEVGGVHIQ-TGIDCEPLL------------LNVLHLDTSSDGEKCCQVIESPHVFPANAEVGT 676

  Fly  1185 YATK------VECVDVVGTGSSSGHQSDEEAQLRKPTRAYKLLVGTHMRMGAFKKHIEQLIQVPA 1243
            ..|.      |..::..|.....|..:..:..:||..|...|..|:.:
Human   677 VLTALAIPAGVIFINSAGCPGGEGWTAIPKEDMRKTFREQGLRNGSSI----------------- 724

  Fly  1244 AHFKLQRKHDNN----------LSNNQNNSLVHL-----IEGETLTVELGKTLEPDEFKAKIHFL 1293
               .:|..||:|          .|.|:.:.| |:     :|.|...|::..|:....|..:|..:
Human   725 ---LIQDSHDDNSLLTKEEKWVTSMNEIDWL-HVKNLCQLESEEKQVKISATVNTMVFDIRIKAI 785

  Fly  1294 R-------LAD------IDNETSKLPCVCEWVYNANTTAEQAKKELVAKLHRIDAKYATLSVQNC 1345
            :       |||      || ...||.|.....|    |.::|:.::.:.|.....| |..|.|..
Human   786 KELKLMKELADNSCLRPID-RNGKLLCPVPDSY----TLKEAELKMGSSLGLCLGK-APSSSQLF 844

  Fly  1346 RIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPKDDSLTLFVRR--------- 1401
            ..:..|.               |::.....|.:|   ||.:..:   |.|.|.:::
Human   845 LFFAMGS---------------DVQPGTEMEIVV---EETISVR---DCLKLMLKKSGLQGDAWH 888

  Fly  1402 -----WCPAKLEFG---------KFQEITLD--------QDSEIRLSLSQISDI------PIDKL 1438
                 ||   .|.|         :.|.|||.        ||:.::..|....|.      .:..|
Human   889 LRKMDWC---YEAGEPLCEENSARSQLITLGTGFSFQPCQDATLKELLICSGDTLLLIEGQLPPL 950

  Fly  1439 SYMKL-----------------NSNFPCTSISALSVNESSSWYSVPTTLDKYPLNSTQ------- 1479
            .::|:                 .....||          |||..|      :...|:|
Human   951 GFLKVPIWWYQLQGPSGHWESHQDQTNCT----------SSWGRV------WRATSSQGASGNEP 999

  Fly  1480 -------TGNIYLYKDRTV--------------------PA--RELTLEERR----LMNAREKAR 1511
                   .|:|.:.:|.|:                    ||  |..|:|.:|    |...|:..|
Human  1000 AQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWTVERKRPGRLLRTDRQPLR 1064

  Fly  1512 LDRVGCVSTTRYAQRRERALKIYLDSPEKSSNVTASAPMDV 1552
            ..::|            |.::|.|:..:|..|:   .|.||
Human  1065 EYKLG------------RRIEICLEPLQKGENL---GPQDV 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	116/400 (29%)
		UCH	395..776	CDD:278850	116/395 (29%)
USP40	NP_001369225.1	peptidase_C19C	39..344	CDD:239124	117/414 (28%)
USP40	NP_001369225.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D77113at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020