DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and USP47

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	NP_001317137.1	Gene:	USP47 / 55031	HGNCID:	20076	Length:	1375	Species:	Homo sapiens

Alignment Length:	1457	Identity:	492/1457 - (33%)
Similarity:	703/1457 - (48%)	Gaps:	262/1457 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 STEINSK---NTSSESPVAKKTAKVTSK-----PTLELLSPIKPSSPIKELDCEPVDTLSKQQLS 263
            |..:|.:   |..:.:||.|....|.:|     .|.:|:.    .:.|...|..|:|..|.:.|.
Human    53 SKTVNERITLNLPASTPVRKLFEDVANKVGYINGTFDLVW----GNGINTADMAPLDHTSDKSLL 113

  Fly   264 EQLQLYPQGRNLISPVDDAPSDLFISDAEQ---LSDDDLALGASASPTMLGPGYDYGAPTGDSDV 325
            : ....|..:|.:...|        .|.||   |.:|..|...|.....:||     .|.
Human   114 D-ANFEPGKKNFLHLTD--------KDGEQPQILLEDSSAGEDSVHDRFIGP-----LPR----- 159

  Fly   326 EGVTGVTDPSTIGTDDGTYPALSNFYRRKYGGDELRAWQRVNTTGADFVSSATTETEAEARQASL 390
            ||..|.|               |::..:.|.                 .||...::|.
Human   160 EGSGGST---------------SDYVSQSYS-----------------YSSILNKSET------- 185

  Fly   391 GPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNE--AKNIPYQLQKLFLNLQTSP 453
               |||||||||||||||||||.||||||||||||:|||:...|  ..:||||||:||:.||||.
Human   186 ---GYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSK 247

  Fly   454 KAAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCL 518
            |.|:||||:||||||||:|||||||:||||||||||||.|:|.|:||:||:.||:||:.|||:||
Human   248 KRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCL 312

  Fly   519 ECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGL 583
            ||..|..|.||:|||||.:||:|||.|:.|:||||.||:|||.|||.|||.||:|||||||.|||
Human   313 ECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGL 377

  Fly   584 HFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCS 648
            .|..|||:|||.||||||||.||||||||||:|||:.|:::|||:.......|..         |
Human   378 RFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTFIDVEDEKSPQTE---------S 433

  Fly   649 TADSGSAMEDDNLSSGVVTTASSSQHENDL-NDE--DEGI--DMSSSTSKSAKQG--SGPYLYEL 706
            ..|||:..|.         :..|.|..||. ||:  ||||  :.:|.|.|.:|.|  ....:|||
Human   434 CTDSGAENEG---------SCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYEL 489

  Fly   707 FAIMIHSGSASGGHYYAYIKDFDNNEWFCFNDQNVTSITQEDIQRSFGGPNGS--YYSSAYTSST 769
            |::|:|||||:||||||.||.|.:.:|:.||||:|:.||||||:::.||.:||  |||||:.|||
Human   490 FSVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASST 554

  Fly   770 NAYMLMYRQVDAKRNELVAKVADFPEHIKTLLPKLH--SEEETRVSRLGRHITVTDLALPDLYKP 832
            |||||:||..|..||....:|.::|||||.|:.|..  .|:|.|...:.|:..          |.
Human   555 NAYMLIYRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTC----------KI 609

  Fly   833 RVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDTIIQSLES 897
            :::..:|:.:.|...::.|.:...:...:..||:|:::|:..||..||||.|:...|.:.:|.|.
Human   610 KLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEVIPLDCCRLVKYDEFHDYLERSYEG 674

  Fly   898 CTDPALTELRAA--QNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAR 960
            ..|..:..|...  ..|..|.|||.|..||.|:.|.|..:...|..|||...::..|..|  .|.
Human   675 EEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQSYKPGEVMVKVHVVDLKAESVAAPITV--RAY 737

  Fly   961 EREASDVLRRSIALRLHISEQQF------------LLATVRATVP--------KAFVSYDPHPTP 1005
            ..:.....::.|:..:|:..:..            ||:....|:.        |.||.     :.
Human   738 LNQTVTEFKQLISKAIHLPAETMRIVLERCYNDLRLLSVSSKTLKAEGFFRSNKVFVE-----SS 797

  Fly  1006 EAL--------QHLQNMANTQFKSITYFYLNVP---------------------NTDAATLEMLG 1041
            |.|        .||..:.:....:|..|.| :|                     |.|.....:.|
Human   798 ETLDYQMAFADSHLWKLLDRHANTIRLFVL-LPEQSPVSYSKRTAYQKAGGDSGNVDDDCERVKG 861

  Fly  1042 -VPTVESVEC----------------ASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEPM 1089
             |.:::|||.                ...||..|::          .|:...|:...:..|.|..
Human   862 PVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSS----------KSTETSDFENIESPLNERD 916

  Fly  1090 SQPSPSH----GHESNSEDSSLSDGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHD 1150
            |..|..:    .|...|:..:....:|:..:.:|.......||.:.|:|||..
Human   917 SSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSD------------ 969

  Fly  1151 AMMRVHAYCNG-NGSYAAADVVDPLLLPTSTNHFFYATKVECVDVVGTGSSSGHQSDEEAQLR-- 1212
                  ..||. |.....|:.:|...:.:|........|.|..|.....|.:..:.||..:.|
Human   970 ------TLCNADNAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGE 1028

  Fly  1213 --------KPTRA-------YKLL---VGTHMRMGAFKKHIEQLIQVPAAHFKLQRKHDNNL--- 1256
                    :|..|       :|.|   |...:.:.|||:|:|..:.|.::|||:.|.:.:|.
Human  1029 MQYMYFKAEPYAADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFE 1093

  Fly  1257 SNNQNNSLVHLIEGETLTVELGKTLEPDEFKAKIHFLRLADIDNETSKLPCVCEWVYNANTTAEQ 1321
            |...|.:|....:...:|:.||:.|:..|::.|::.|    :.||......:.:.|:....|..|
Human  1094 SVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVYQL----LVNEQEPCKFLLDAVFAKGMTVRQ 1154

  Fly  1322 AKKELVAKLHRIDAKYATLSVQNCRIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEV 1386
            :|:||:.:|.  :.....||:...|:..|..:.|..:..|......|:..|...| :..|..:.|
Human  1155 SKEELIPQLR--EQCGLELSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWE-VFLEVLDGV 1216

  Fly  1387 DPQPKDDSLTLFVRRWCPAKLEFGKFQEITLDQDS--EIRLSLSQISDIPIDKLSYMKLNSNFPC 1449
            :.......|.:..|||.|::::...|||:.|:..|  |:|..||:||.||:|.:.:.|....|||
Human  1217 EKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLSEISGIPLDDIEFAKGRGTFPC 1281

  Fly  1450 TSISALSVNESSSWYSVPTTLDKYPLNSTQTGNIYLYKDRTVPARELTLEERRLMNAREKARLDR 1514
             .||.|.:::...|....:||:.:||.....|.:..|:|:|....|||.|:|..:..:|.:||.:
Human  1282 -DISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDEQRNELMKKESSRLQK 1345

  Fly  1515 VGCVSTTRYAQRRERALKIYLD-SPEK 1540
            .|  ....|:.|:|:||||||| :|.|
Human  1346 TG--HRVTYSPRKEKALKIYLDGAPNK 1370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188	8/34 (24%)
		Rib_recp_KP_reg	122..265	CDD:282899	16/65 (25%)
		peptidase_C19C	394..780	CDD:239124	244/396 (62%)
		UCH	395..776	CDD:278850	241/391 (62%)
USP47	NP_001317137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..452		8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..859		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..968		18/97 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	983..1024		8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160338
Domainoid	1	1.000	477	1.000	Domainoid score	I432
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9929
Inparanoid	1	1.050	693	1.000	Inparanoid score	I688
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47402
OrthoDB	1	1.010	-	-		D387934at33208
OrthoFinder	1	1.000	-	-		FOG0006160
OrthoInspector	1	1.000	-	-		oto91063
orthoMCL	1	0.900	-	-		OOG6_106012
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3900
SonicParanoid	1	1.000	-	-		X4445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800