DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and puf

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster

Alignment Length:	1410	Identity:	278/1410 - (19%)
Similarity:	482/1410 - (34%)	Gaps:	441/1410 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 GYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEA-KNIP--YQLQKLFLNLQTSPKA 455
            |||||.|...|||:.|.:|.|:|.|:.|.|:.|..   .|.| |:.|  .:||::|..|..|.:.
  Fly  2013 GYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVP---PNAARKHGPTLLELQRMFAYLLESERK 2074

  Fly   456 AVETTDLTRSFGWD--STEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCL 518
            :.......|.:..|  .....:|.|:.|....:...||....:.|  :|:..|:.|.:::.|..|
  Fly  2075 SYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPDLK--HLVKRLFCGSLSNNVVSL 2137

  Fly   519 EC-NTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKG 582
            :| :..:|.|| |..:...|      :...:::|:|......:||:|:|.|.|.:|.||..|.|.
  Fly  2138 DCGHVSRTAED-FYTVRCQV------ADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKR 2195

  Fly   583 LHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDC 647
            ..||..|.||..:..|:.|:..||.:.|:|...:||..||:..::.::....:...:......:.
  Fly  2196 ACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEK 2260

  Fly   648 STADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIH 712
            ..|| ||...:||           .:.|..|:|:.|..                |.|||..:.:|
  Fly  2261 EGAD-GSGDGNDN-----------EKAEATLDDDIEEC----------------YEYELVGVTVH 2297

  Fly   713 SGSASGGHYYAYIKD------FDNNEWFCFNDQNVTSITQEDI-QRSFGGPNGS---------YY 761
            :|:|.|||||::||:      ..:..||.|||..|.......| ...|||...|         |.
  Fly  2298 TGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQIAAECFGGEMTSKTYDSVTEKYL 2362

  Fly   762 SSAYTSSTNAYMLMYRQ-----VDAKRNELVAKVADFPEHIKTLLPKLHSEEETRVSRLGRHITV 821
            ..::..:.:||||.|.:     :..:.:||:......|    |:..|..:||.|::......|..
  Fly  2363 DFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPTPSP----TVEEKSEAEEPTKMETSSSEIKA 2423

  Fly   822 -----TDLALPDLYKP-------------------RVYFYNPSLKKM-KITRVYVSQSFNINLVL 861
                 .::...|..||                   :.....|..||: |.:|....:|....
  Fly  2424 DVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETDE--- 2485

  Fly   862 MSAYEMLNV---EQFAPLSRCRLVAYNSSMDTIIQSLESCTDPALTELRAAQNYSLDF--LLEYR 921
             ...||..|   |:..|.:.|.....|::.::     ::..|...:..:|||...| |  ||...
  Fly  2486 -KPTEMTTVSTEEEKQPTANCDNHQQNNNSNS-----KASNDQQPSTSKAAQKLQL-FRPLLNKE 2543

  Fly   922 AED----------QEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREASDVLRRSIALRL 976
            .||          |:..::..   |::.|...:.      ..:..|...|.:.:     .:|.:|
  Fly  2544 LEDWIWQDNRQFLQDRNIFEH---TYFNFMWQIC------GHIPQSLISETDVT-----CMAAKL 2594

  Fly   977 HISEQQFLLATVRATVPKAFVSYDPHPTPEA-LQHLQNMANTQFKSITYFYLNVPNTDAATLEML 1040
            .:|   |.:.|        |:.....||... ::.|....|...::..:|..::.......:::|
  Fly  2595 SVS---FFIET--------FIHAKEKPTMVPWVELLTKQFNASQEACEWFLSHMSQEPYWPVQVL 2648

  Fly  1041 GVPTVESVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGH---ESNS 1102
                   ::|                |..|..      :.::|.::..:.|...||.|   |..:
  Fly  2649 -------IQC----------------PNQMVR------QMFQRLVIHVIQQLRASHAHLYLEVET 2684

  Fly  1103 EDSSLSDGDRTLVETDNMAHRGGGDSQVSSTSHSP---------------QLSSPEDEAASHDAM 1152
            ::.     |:.|:...:...|..| |.:|...|..               :.|...||.|.:  :
  Fly  2685 DED-----DKELIGQASCVTRFIG-SLISLLEHGARANLRHLSEYFGLLCEFSRMGDEEAMY--L 2741

  Fly  1153 MRVHAYCNGNGSYAAADVVDPLLLPTSTNHFFYATKVECVDVVGTGSSSGHQSDEEA---QLRKP 1214
            :|:.                  :|.:..:.:....:.:.:|:   .|.:...|.|||   :..:|
  Fly  2742 LRIG------------------VLKSLVDFYLGHKQTDSIDI---SSDNEDNSSEEALSVEKMRP 2785

  Fly  1215 TRAYKLLV----------GTHMRMGAFKKHIEQLIQVPAAHFKLQRKHDNNLSNNQNNSLVHLI- 1268
            ....|::.          |...|:....|....:.......|..|:..| .::.:|...|:|.:
  Fly  2786 ASLDKMIALCASLVERSRGADFRLRLSPKDFSAIAGGKGFPFLYQQIKD-GINPHQTKHLIHALC 2849

  Fly  1269 -EGETLTVEL-----GKTLEPDEFKAKIHFLRLADIDNETS----KLPC---------------- 1307
             ..|.|..::     ....:..|..|.  |.:|..:..||.    .|||
  Fly  2850 RWDERLATQIIGMLFASVTKHTELCAP--FFKLLTLLTETQGGPVGLPCFTQLILPRMWDAAEYC 2912

  Fly  1308 ---VCEWVYNANTTAEQAKKELVAK----------LHRIDAKYATLSVQNCRIWLKGGRIPI--- 1356
               |.:|:      :.||.|..:|.          |.:....:....|:|...:|....:|.
  Fly  2913 PQSVLDWL------SLQATKNKIAHAWILQSAEKWLEQFLLAHDNTRVRNAAAFLLVALVPSQPF 2971

  Fly  1357 ----------KILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPKDDSLTLFVRRWCPAKLEFGK 1411
                      |:|:.:...|.|:.|.  |:.::.:.            :||.:|...||::
  Fly  2972 RANFRAHSQHKLLALNPHSYRDINSD--AQAVLHQV------------ITLLLRLLRPARV---- 3018

  Fly  1412 FQEITLDQDSEIRLSLSQISDIPIDKL------SYMKLNSNFPCTSISALSVNESSSWY------ 1464
            :.:|.....:::....:.:|...:.|.      |||:                  |.|.
  Fly  3019 YADIGAHGTTKLTAYFNLLSYCMVSKTEKLMASSYMR------------------SLWELFHPRL 3065

  Fly  1465 ---SVPTTLDKY-------------PLNSTQTGN---------------------IYLYKDRTVP 1492
               |||...:|:             |.|:.|..|                     |..|....:|
  Fly  3066 SEPSVPAHHNKHALLTFWHHSLVDCPENAAQVANCPEITRNIAFNYILADHDDAEIVTYNRSMLP 3130

  Fly  1493 A----------------RELTLEER-----------------------RLM--------NAREKA 1510
            |                |:|:..:.                       :||        :|.|:.
  Fly  3131 AYYGLLRLCCEQSRALTRQLSQHQNLQWAFKNITPHPTQYAAAVDELFKLMALFATRHPDASEQE 3195

  Fly  1511 RLD-----RVGCVSTTRYAQRRE------RALKIYLDSPEKSSNV 1544
            :||     |...||.|.....|.      .||||.:|:.|..:.|
  Fly  3196 KLDVTQFRRAVIVSYTSSLDARVSWSTLISALKILVDNEEDRTMV 3240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	114/412 (28%)
		UCH	395..776	CDD:278850	112/402 (28%)
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	114/408 (28%)
		UCH	2014..2377	CDD:278850	112/402 (28%)
		DUF3517	2723..>2877	CDD:288853	27/179 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910