Protein Alignment Usp47 and Usp8

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Alignment Length: 814
• Identity: 175/814 - (21%)
• Similarity: 292/814 - (35%)
• Gaps: 253/814 - (31%)

  Fly    34 TVKRVIDLIGTQFSYEKFELLLQPH-----------DNKDLVNLNALESQLMYEVAGFEPQLKNH 87
            |.:..|.::  :..||.|.::...|           :|.|:..::.:|...::::...|
  Fly   255 TYRAPIQIV--EGGYEYFIMMYPTHCTNPSVQAPQQNNNDIETIDDIEYPSIHDITMKE------ 311

  Fly    88 LILLPSGSWDGDVTKRFELPIKRVVVKKVMKSDGEKAKSPATGEKKKRVVGEKTKKKPASGSSSP 152
                       |::.:...|          :.|..:|..||...     |.|:...:|    |.|
  Fly   312 -----------DISAKDFRP----------RPDFNRANKPAATR-----VNEQGISRP----SPP 346

  Fly   153 SKAKTTSEDSLAKTSISSESSPEKTSKIKTTAAKISKPGSEKAPRASPEECPELSTEINSKNTSS 217
            :|.........|:....:|.:.|:..|    |:|:.|..:.:....:..|..||...|....:.:
  Fly   347 AKPIAEIMRDQAEFLQRAEQNDEQLEK----ASKMWKRQAAEGDGLNATEDQELHFRILQLESKA 407

  Fly   218 ESPVAKKTAKVTSKPTLELLSPIKP----SSPIKELDCEPVDTL-----SKQQLSEQLQLYPQGR 273
            :..:      |.:....|.||.|:.    :..:.:.:.|....:     .:|:|.||.:|..|.|
  Fly   408 QDYI------VENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKIRERQRLDEQHELERQER 466

  Fly   274 NLISPVDDAPSDLFISDAEQLSDDDLALGASA-----SPTMLGPGYDYGAPTGDSDVEGV----- 328
                              |:|    ||:....     |||..||      |:...::|.|
  Fly   467 ------------------ERL----LAIARETKKHYKSPTPSGP------PSPGRNLEDVHVVSD 503

  Fly   329 --------TGVTDPSTIGTDDGTYPALSNFYRRKYGGDELRAWQRVNTTGADFVSSATTETEAEA 385
                    ||..|| ||..:....|......:.:....| |..|||.    ||         :..
  Fly   504 SLESLLQLTGDPDP-TIAPNKAEIPTFDRAMKPQPRNVE-RTSQRVR----DF---------SPV 553

  Fly   386 RQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPE---------FRNALYRWEFDNDNEAKNIPYQ 441
            ...::| ||..||.|...|||:||:||.|..||:         ::|.:.|....|....:.:...
  Fly   554 IGQNVG-RGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAAL 617

  Fly   442 LQKLFLNLQTSPKAAVETTDLTRSFG-----------WDSTE------AWQQHDIQEL----CRV 485
            :::|:    ......|.:.||....|           .||.|      .|...|:|.|    .|.
  Fly   618 IKELW----NGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQRE 678

  Fly   486 MFDALEH---KFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYG 547
            |..|.|.   :|...|: ::|.:|:.|:|...|||:.|:.|....::|.::.|.:.|   :|...
  Fly   679 MISASEKAWLEFTKAKE-SMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPP---NSNVC 739

  Fly   548 SIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLN 612
            .:.:.:..:...|.:.|.|   |..||.|.||.|.|.....|.:|.:|||||..|
  Fly   740 QLNQCMDMYFSGERIHGWN---CPSCKTKRDAIKKLDISKLPPVLVVHLKRFYAD---------- 791

  Fly   613 DRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHEND 677
                                                .::|||.|                :.:|.
  Fly   792 ------------------------------------PSNSGSYM----------------KKQNY 804

  Fly   678 LNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKDFDNNEWFCFNDQNVT 742
            |....|.:||:...:::..:...|..|:|:|:..|.|:..||||.|:.|..:..:||.|:||.|:
  Fly   805 LRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVS 869

  Fly   743 SITQEDIQRSFGGPNGSYYSSAYTSSTNAYMLMY 776
            ::...::           .|||      ||:|.|
  Fly   870 ALDSSNV-----------VSSA------AYILFY 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066	25/130 (19%)
		peptidase_C19C	394..780	CDD:239124	101/416 (24%)
		USP47_C	1300..1534	CDD:466158
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705	5/24 (21%)
		Smc	<361..>511	CDD:440809	35/187 (19%)
		Peptidase_C19R	564..887	CDD:239139	100/413 (24%)