DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and usp25

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	XP_009303832.1	Gene:	usp25 / 406790	ZFINID:	ZDB-GENE-040426-2847	Length:	1166	Species:	Danio rerio

Alignment Length:	1031	Identity:	215/1031 - (20%)
Similarity:	340/1031 - (32%)	Gaps:	382/1031 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 EPVDTLSKQQLSEQLQL----------YPQGRNLISPVDDAPSDLFISDAEQLSDDDLALGASAS 306
            |...|...|.|.:.||:          :...:|...|..|..:  :...|:..:|..:::|:.|
Zfish    25 EVTGTTDVQLLQQALQVSNGDLVEAVAFLTEKNAKVPQQDEAT--YYQTAQITNDRYISVGSQA- 86

  Fly   307 PTMLGPGYDYGAPTGDSDVEGVTGVTDPSTIGTDDGTYPALSNFYRRKYGGDEL----------- 360
                           |::|..:||         ||               .|:|
Zfish    87 ---------------DTNVIDLTG---------DD---------------KDDLQRAIALSLEES 112

  Fly   361 -RAWQRVNTTGADFVSSATTETEAEARQASL----------GPRGY---------VGLVNQAMTC 405
             ||::....|..:...|...|......:|||          .|..:         |||.|...||
Zfish   113 NRAFRETGITDEEQAISRVLEASIAENKASLKRTHTEVWSDSPNPHERKRMENCPVGLKNVGNTC 177

  Fly   406 YLNSLLQALFMTPEFRNALYRWEFD--------NDNEAKNIPY--QLQKLFLNLQTS------PK 454
            :.::::|:||...||:..:..:...        |..|.:|:|:  :|:.||..|..|      |.
Zfish   178 WFSAVIQSLFNLLEFQRLVLHYSPPARMQDLPRNQKEHRNLPFMQELRHLFSLLVGSKRKYVDPS 242

  Fly   455 AAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKF--------KNTKQANLISNLYEGKM 511
            .|||.  |..:|  .|:|: ||.|:.|....:.|.||..|        :..|..|.:..|:.|:.
Zfish   243 GAVEI--LKDAF--KSSES-QQQDVSEFTHKLLDWLEDAFQIKAEEDREGEKPKNPMVELFYGRF 302

  Fly   512 NDYVKCLEC----NTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYL--C 570
            . .|..||.    |||     .|...||.|      :.:..:.|.|.|.:    ::|..:.|  .
Zfish   303 L-AVGVLEGKKFENTE-----MFGQYPLQV------NGFKDLHECLEAAM----IEGEIESLHSA 351

  Fly   571 EKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINR------ 629
            |...|....|   .|...|.:||..|.||:|:.......|:::::.||..|.::.:::|
Zfish   352 ENSAKSGQEH---WFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPSMLYMDRYMDRNREITR 413

  Fly   630 ------------------------SGNSGEQNSQL------------------------------ 640
                                    |..||.:...|
Zfish   414 IKREEIRRLKEHLTVLQQRLERYLSYGSGPKRFPLADVLQYAMEFASSKPVCTSPVEDIDTTAPP 478

  Fly   641 NGTV-------------DDCSTAD-SGSAMEDDNLSSGVVT-----TAS---------------- 670
            .||:             |.|.:|: |||.::........|:     |.|
Zfish   479 GGTIAQLPPPASAGEQPDACVSAEGSGSGLQASQQQQQRVSIHKPFTQSRVPPDLPMHPAPRHIT 543

  Fly   671 --------------SSQHENDLNDEDEGIDMSSST------SKSAKQGSGPYLYELFAIMIHSGS 715
                          .|:.|||..|....|.....|      .||..|    ..|.|.|:::|.|.
Zfish   544 EEELRVLESCLHRWRSEVENDTRDLQASISRIHRTIELMYSDKSMMQ----VPYRLHAVLVHEGQ 604

  Fly   716 ASGGHYYAYIKDFDNNEWFCFNDQNVTSITQEDIQR-SFGGPNGSYYSSAYTSSTNAYMLMYRQV 779
            |:.|||:|||.|..:..|..:||..||..:.|::.| ||||     |.:|     :||.|||  :
Zfish   605 ANAGHYWAYIYDRHHQRWMKYNDIAVTKSSWEELVRDSFGG-----YRNA-----SAYCLMY--I 657

  Fly   780 DAKRNELVAKVADFPEHIKTLLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKM 844
            |.|:..|:.:..|               :||     |:.::..|...|||
Zfish   658 DDKKPFLIQEEFD---------------KET-----GQMLSGLDKLPPDL--------------- 687

  Fly   845 KITRVYVSQSFNINLVLMSAYEMLNV-----EQFAPLSRCRLVAYNSSMDTIIQSLESCTDPALT 904
               :|:|.....:....|..::.|..     |:.| |:.....|..:|:.....|.|.|: |..|
Zfish   688 ---KVFVEADNKLFEREMEEWDALQARKLQQEKLA-LAAAAAAAAAASVAVQPMSTEPCS-PDNT 747

  Fly   905 ELRAAQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREASDVLR 969
            ...||..:..:::          |...|:|        |...:..|....:..||.|.:.
Zfish   748 APSAAPQHDPEYM----------EQQSPSG--------DSKHLQEDTERAISKAAAEHDE----- 789

  Fly   970 RSIALRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYFYLNVPNTDA 1034
                     ...:.||.|.:::.|.:.::.||.|.|:                       |..|.
Zfish   790 ---------KSPEALLNTSQSSHPDSKLTSDPCPPPD-----------------------PEQDD 822

  Fly  1035 ATLEMLG--------VPTVES--VECASGGDVVDAAM---MNGVAPGHMSSSNDYD 1077
            .|....|        :|.|.:  ::...||...:|.|   |.|:......|.:.||
Zfish   823 PTCPPPGPQRVVEVAIPNVGTFVIQSKEGGYDDEAMMTPNMQGIIMAIGKSRSVYD 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899	4/12 (33%)
		peptidase_C19C	394..780	CDD:239124	127/540 (24%)
		UCH	395..776	CDD:278850	125/535 (23%)
usp25	XP_009303832.1	UBA_UBP25	14..59	CDD:270539	7/33 (21%)
		UCH	167..>408	CDD:278850	70/264 (27%)
		Peptidase_C19I	169..657	CDD:239130	126/527 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910