DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and USP41

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	XP_016884653.1	Gene:	USP41 / 373856	HGNCID:	20070	Length:	336	Species:	Homo sapiens

Alignment Length:	371	Identity:	100/371 - (26%)
Similarity:	157/371 - (42%)	Gaps:	67/371 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 LGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDN--DNEAKNIPYQLQKLFLNLQTS 452
            :.|...|||.|...||.||||:|...|..:|...|.|.....  |.:.:::|:|:..|...:|.|
Human    27 MDPLCLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQDS 91

  Fly   453 PKAAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKC 517
            .:.||...:|.......:...:.|||..:|...:::.::.:..:......:..||..:|.|.:.|
Human    92 RQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQALYMIRMKDSLIC 156

  Fly   518 LECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKG 582
            |:|..|.:|..:.|.:.|..... .|....::|:||..|.||..|...::..||.|.||....:.
Human   157 LDCAMESSRNSSMLTLRLSFFDV-DSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQV 220

  Fly   583 LHFKSFPYILTLHLKRFDF-DYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDD 646
            |.....|..||:||.||.. :.||.   |:...:.|||:|:.              ||:
Human   221 LKLTHLPQTLTIHLMRFSIRNSQTR---KICHSLYFPQSLDF--------------SQI------ 262

  Fly   647 CSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMI 711
                                                  :.|...:..:.:|..|.  |||||::.
Human   263 --------------------------------------LPMKRESCDAEEQSGGQ--YELFAVIA 287

  Fly   712 HSGSASGGHYYAYIKDFDNNEWFCFNDQNVTSITQEDIQRSFGGPN 757
            |.|.|..|||..||::..:.:||||||.|:..::.||||.::|.||
Human   288 HVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPN 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	99/367 (27%)
		UCH	395..776	CDD:278850	99/366 (27%)
USP41	XP_016884653.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010