DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp47 and Usp7

DIOPT Version :9

Sequence 1:NP_523937.2 Gene:Usp47 / 38644 FlyBaseID:FBgn0016756 Length:1556 Species:Drosophila melanogaster
Sequence 2:NP_001019961.1 Gene:Usp7 / 360471 RGDID:1306915 Length:1103 Species:Rattus norvegicus


Alignment Length:1158 Identity:260/1158 - (22%)
Similarity:434/1158 - (37%) Gaps:370/1158 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   340 DDGTYP-ALSNFYRRK---YGGDELRAWQRVNTTGADFV--SSATTE--TEAEARQA----SLGP 392
            ||.::. .:|:.:..|   :|.....||..|......|:  ...|.|  .:|:|...    |...
  Rat   147 DDKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKH 211

  Fly   393 RGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPKAAV 457
            .|||||.||..|||:|||||.||.|.:.|.|:|....:.|:.:|::|..||::|..||.|.| .|
  Rat   212 TGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK-PV 275

  Fly   458 ETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNT 522
            .|..||:||||::.:::.|||:||||||:.|.:|:|.|.|.....|..|:.|||..|::|.|.:.
  Rat   276 GTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDY 340

  Fly   523 EKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKS 587
            ...|.:.:.||.|.::  |..:.:.|..:    :|..|.|||:|:|...:...: :|.||:.|.:
  Rat   341 RSDRREDYYDIQLSIK--GKKNIFESFVD----YVAVEQLDGDNKYDAGEHGLQ-EAEKGVKFLT 398

  Fly   588 FPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADS 652
            .|.:|.|.|.||.:|.||...||:|||..||:.|.|:.|:.::                      
  Rat   399 LPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKT---------------------- 441

  Fly   653 GSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSAS 717
                                    |..|                    |..|.|.|:::|||...
  Rat   442 ------------------------DPKD--------------------PANYILHAVLVHSGDNH 462

  Fly   718 GGHYYAYIKDFDNNEWFCFNDQNVTSITQED-IQRSFGGPNGSYYSSAYTSSTNAYMLMYRQVDA 781
            ||||..|:....:.:|..|:|..|:..|:|: |:.::||.:...   :....||||||:|.: ::
  Rat   463 GGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDL---SVRHCTNAYMLVYIR-ES 523

  Fly   782 KRNELVAKVA--DFPEHIKTLLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKM 844
            |.:|::..|.  |.|:.:...|     :||.|:....|                        |:.
  Rat   524 KLSEVLQAVTDHDIPQQLVERL-----QEEKRIEAQKR------------------------KER 559

  Fly   845 KITRVYVSQSFNINLVLMSAY------EMLNVEQFAPLSRCRLVAY----NSSMDTIIQSLESCT 899
            :...:|:    .:.:|....:      :|.:.|      :.|...:    |||:...:|||....
  Rat   560 QEAHLYM----QVQIVAEDQFCGHQGNDMYDEE------KVRYTVFKVLKNSSLAEFVQSLSQTM 614

  Fly   900 DPALTELRAAQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREA 964
            .....::|.       :.::.|:...:......|........::||.  .:.|:.::....:.| 
  Rat   615 GFPQDQIRL-------WPMQARSNGTKRPAMLDNEADGSKTMIELSD--NENPWTIFLETVDPE- 669

  Fly   965 SDVLRRSIALRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYF-YLN 1028
                                ||...||:||....:|       :.....|.:.:.:|:.|. ::.
  Rat   670 --------------------LAASGATLPKFDKDHD-------VMLFLKMYDPKTRSLNYCGHIY 707

  Fly  1029 VPNTDAATLEMLGVPTVESVECASGGDVVDAAMM--NGVAPGHMSSSNDYDWRRYKRDLVEPMSQ 1091
            .| ......::|      .|.|...|.:.|.:::  ..|.|.......|||              
  Rat   708 TP-ISCKIRDLL------PVMCDRAGFIQDTSLILYEEVKPNLTERIQDYD-------------- 751

  Fly  1092 PSPSHGHESNSEDSSLS---DGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMM 1153
                     .|.|.:|.   |||..:.:.|:                      ||::.:.     
  Rat   752 ---------VSLDKALDELMDGDIIVFQKDD----------------------PENDNSE----- 780

  Fly  1154 RVHAYCNGNGSYAAADVVDPLLLPTSTNHF--FYATKVECVDVVGTGSSSGHQSDEEAQLRKPTR 1216
                                  |||:..:|  .|    ..|||:....:..:...          
  Rat   781 ----------------------LPTAKEYFRDLY----HRVDVIFCDKTIPNDPG---------- 809

  Fly  1217 AYKLLVGTHMRMGAFK--KHIEQ-------LIQVPAAHFKLQRKHDNNLSNNQNNSLVHLIEGET 1272
               .:|....||..|:  |.:.|       |:|    .||.|...|     ...|.|.|..|| |
  Rat   810 ---FVVTLSNRMNYFQVAKTVAQRLNTDPMLLQ----FFKSQGYRD-----GPGNPLRHNYEG-T 861

  Fly  1273 LTVELGKTLEPDEFKAKIHF----LRLADIDNETSKLPCVCEWVYNANTTAEQAKKELVAKLHRI 1333
            |. :|.:..:|.:.| |:::    :::.|.:|..| ..|                          
  Rat   862 LR-DLLQFFKPRQPK-KLYYQQLKMKITDFENRRS-FKC-------------------------- 897

  Fly  1334 DAKYATLSVQNCRIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPKDDSLTLF 1398
                         |||..     :...::.|||.|....:  ..:::||::.|:   ..|..:..
  Rat   898 -------------IWLNS-----QFREEEITLYPDKHGCV--RDLLEECKKAVE---LGDEASGR 939

  Fly  1399 VRRWCPAKLEFGKFQEITLDQDSEIRLSLS-------QISDIPIDKLSYMKLN 1444
            :|     .||...::.|.:.|:.|:...||       :|.:||:|:::..|.|
  Rat   940 LR-----LLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVNIDKEN 987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp47NP_523937.2 TEBP_beta <119..234 CDD:254188
Rib_recp_KP_reg 122..265 CDD:282899
peptidase_C19C 394..780 CDD:239124 127/386 (33%)
UCH 395..776 CDD:278850 125/381 (33%)
Usp7NP_001019961.1 Interaction with TSPYL5. /evidence=ECO:0000250|UniProtKB:Q93009 1..209 13/61 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
Interaction with p53/TP53 and MDM2. /evidence=ECO:0000250|UniProtKB:Q93009 54..209 13/61 (21%)
COG5077 56..1101 CDD:227409 260/1158 (22%)
MATH_HAUSP 68..203 CDD:239741 13/55 (24%)
Necessary for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q93009 71..206 13/58 (22%)
peptidase_C19C 213..524 CDD:239124 127/388 (33%)
USP7_ICP0_bdg 621..866 CDD:289221 64/388 (16%)
USP7_C2 876..1087 CDD:291217 30/167 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5077
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D387934at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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