DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and Usp28

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	XP_006243068.1	Gene:	Usp28 / 315639	RGDID:	1311555	Length:	1143	Species:	Rattus norvegicus

Alignment Length:	1068	Identity:	220/1068 - (20%)
Similarity:	357/1068 - (33%)	Gaps:	371/1068 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 SKQQLSEQLQLYPQGRNLISPVDDAPSDLFISDAEQLSDDDL--ALGASASPTMLGPGYDYGAPT 320
            |.|.|..||:       .|:.:.| ||  |:.:|.:.|:.|:  |:.......:..|.:|
  Rat    20 SCQMLLNQLR-------EITGIQD-PS--FLHEALKASNGDITQAVSLLTDQRVKEPSHD----- 69

  Fly   321 GDSDVEGVTGVTDPSTIGTDDGTYPALSNFYRRKYGG-DELRA--------WQRVNTTGADF--- 373
                    |..|:||.:.....:...|:......:.. |:|:|        ...:.|...|.
  Rat    70 --------TAATEPSEVEESATSKDLLAKVIDLTHDNKDDLQAAIALSLLESPNIQTDSRDLNRI 126

  Fly   374 --VSSATTETEAEARQASLG----PRGY-------VGLVNQAMTCYLNSLLQALFMTPEFRNALY 425
              .:||.|:.....|....|    |..:       |||.|...||:.::::|:||..||||..:.
  Rat   127 HEANSAETKRSKRKRCEVWGENHNPNNWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVL 191

  Fly   426 RWEFDND--------NEAKNIPY--QLQKLFLNLQTS------PKAAVETTDLTRSFGWDSTEAW 474
            .:....:        .|.:||.:  :||.||..|..|      |.||:   ||.:.....|.|
  Rat   192 SYSLPQNILENCRSHTEKRNIMFMQELQYLFALLLGSNRKFVDPSAAL---DLLKGAFRSSEE-- 251

  Fly   475 QQHDIQELCRVMFDALEHKFK---------NTKQANLISNLYEGKMNDYVKCLECNTEKTRE--- 527
            ||.|:.|....:.|.||..|:         .||..|.:..|:.|..         .||..||
  Rat   252 QQQDVSEFTHKLLDWLEDAFQLAVNVNSNPRTKSENPMVQLFYGTF---------LTEGVREGKP 307

  Fly   528 ----DTFLDIPLPVRPFGSSSAYGSIEEALR-AFVQPETL----DGNNQYLCEKCKKKCDAHKGL 583
                :||...||.|      :.|.:::|.|. |.|:.:..    |.:.:|..|:
  Rat   308 FCNNETFGQYPLQV------NGYHNLDECLEGAMVEGDIALLPSDRSVKYGQER----------- 355

  Fly   584 HFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSG----------------- 631
            .|...|.:||..|.||:|:.......|:::::.|||.:.::.::.:|.
  Rat   356 WFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQVIYMDRYMYKSKELIRSKRESIRKLKEEI 420

  Fly   632 -------------NSG---------------------EQNSQLNGTVD----------------- 645
                         .||                     ...|.|:|:|:
  Rat   421 QVLQQKLERYVKYGSGPSRFPLPDMLKYVIEFASTKPASESCLSGSVEHMTLPLPSVHCPISDLT 485

  Fly   646 --------DCSTADSGS------AMEDDNLSSGVVTTASS------------------------- 671
                    .||....||      |:.:..:.:|..|:..|
  Rat   486 AKESSSPKSCSQNAEGSFSSPEDALPNSEVMNGPFTSPHSSLEMPAPPPAPRTVTDEEMNFVKTC 550

  Fly   672 -----SQHENDLNDEDEGIDMSSSTSKSAKQGSGPYL----YELFAIMIHSGSASGGHYYAYIKD 727
                 |:.|.|:.|....|  ||:|....:....|.|    |.|.|:::|.|.||.|||:|||.:
  Rat   551 LQRWRSEIEQDIQDLKNCI--SSTTQAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYN 613

  Fly   728 FDNNEWFCFNDQNVTSITQEDIQR-SFGGPNGSYYSSAYTSSTNAYMLMY--------------- 776
            .....|..:||.:||..:.|:::| |:||          ..:.:||.|||
  Rat   614 QPRQIWLKYNDISVTESSWEELERDSYGG----------LRNVSAYCLMYINDKLPHCSAEAAHG 668

  Fly   777 -----RQVDAKRNEL-----------VAKVADFPEHIKTLLPKLHSEEETRVSRLGRHITVTDLA 825
                 .:|:|...||           ..:|.::.|.....:|::.|..
  Rat   669 ESDQTAEVEALSVELRQYIQEDNWRFEQEVEEWEEEQSCKIPQMESSP----------------- 716

  Fly   826 LPDLYKPRVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDT 890
                        |.|.:....::...:.|.:....|.|.:.::..||.|........||.
  Rat   717 ------------NSSSQDFSTSQESSAASSHGVRCLSSEHAVIAKEQTAQAIANTAHAYE----- 764

  Fly   891 IIQSLESCTDPALTELRAA-----QNYSLDFLLEYRAEDQEFE-VYPPNGITWYVFKVDLSTM-- 947
                 :|..:.||:|.:.|     |..:|....|..||.::.| ..|||.   .|.:|::.::
  Rat   765 -----KSGVEAALSEHKEAEPEKPQETNLAEQSEQAAEVKDTEAAAPPNS---EVSEVEIPSVGR 821

  Fly   948 ------------------AMDGPFLVYSAAREREASDVLRRSIALRLHISEQQFLLATVRATVPK 994
                              ||.|..|..:.||:....|.....:....|  |:...|..:....|.
  Rat   822 ILVRSDADGYDEEVMLSPAMQGVLLAIAKARQTFDRDGSEAGLIKAFH--EEYSRLYQLAKETPT 884

  Fly   995 AFVSYDPHPTPEALQHLQNMANTQFKSITYFYLN-VPN--TDAATLEMLGVPTVESVECASGGDV 1056
            :      |..|. |||:          :.||:.| .|.  .:...||......:...|.:.....
  Rat   885 S------HSDPR-LQHV----------LVYFFQNEAPKRVVERTLLEQFADRNLSYDERSISIMK 932

  Fly  1057 VDAAMMNGVAPGHMSSSNDYDWRRYKRD 1084
            |..|.:..:.|..|   |..:::|:..|
  Rat   933 VAQAKLMEIGPEDM---NMEEYKRWHED 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899	3/6 (50%)
		peptidase_C19C	394..780	CDD:239124	124/566 (22%)
		UCH	395..776	CDD:278850	122/541 (23%)
Usp28	XP_006243068.1	UBA_UBP28	23..64	CDD:270540	12/50 (24%)
		UCH	161..>399	CDD:278850	71/268 (26%)
		Peptidase_C19I	163..654	CDD:239130	122/533 (23%)
		Peptidase_C19	163..>271	CDD:271592	35/112 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810