DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and Usp24

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	NP_001258135.1	Gene:	Usp24 / 313427	RGDID:	1306799	Length:	2617	Species:	Rattus norvegicus

Alignment Length:	1508	Identity:	325/1508 - (21%)
Similarity:	530/1508 - (35%)	Gaps:	457/1508 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TDKESEQCTVSVFDQTP-GSEQKKINVVVRSHFTVKRVIDLIGTQFSYEKFELLLQPHDNKDLVN 65
            |.::...|      .|| .|..::::|..||...|:.:|...         .:.:|..:..|...
  Rat  1277 TSRQMSLC------GTPEKSSYRQLSVSDRSSIRVEEIIPAA---------RVAIQTMEANDFTA 1326

  Fly    66 LNALESQLMY-------EVAGFEPQLKNHLILLPSGSWDGDVTKRFELPIKRVVVKKVMKSDGEK 123
            ..|...:|.:       ::.|....:|....|.|:|                  ::..:.|.|..
  Rat  1327 TVACFMRLSWAAAAGRLDLVGSSQPIKESNSLFPAG------------------IRNRLSSSGSN 1373

  Fly   124 AKSPATGE-----------------KKKRVVGEK----------TKKKPASGSSSPSKAKTTSED 161
            ..|.:.||                 |...:.||.          ..::.||..|.|..|     |
  Rat  1374 CSSSSEGEPAALHAGICVRQQSVSTKDALIAGEALSLLVTCLQLRSQQLASFYSLPCVA-----D 1433

  Fly   162 SLAKTSISSESSPEK---------TSKIKTTA-AKISKPG--------SEKAPRASP-------- 200
            .:....:.|.|:..:         .|:..|:| .::.||.        :.:.|..||
  Rat  1434 FIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPEVQKPNQFLLGVILTAQLPLWSPTSIMRGVN 1498

  Fly   201 ----EECPE---LSTEINSKNTSSE------SPVAKKTAKVTSKPTLELLSPIKPSSPIKELDCE 252
                .:|.|   |..::....|:||      ||.|....:||.....|         |.:..:||
  Rat  1499 QRLLSQCMEYFDLRCQLLDDLTTSEMEQLRVSPAAMLEDEVTWLDNFE---------PNRTAECE 1554

  Fly   253 PVDT----------LSKQQLS----EQLQLYPQGRNLISP-VDDAPSDLFISDAEQLSDDDLALG 302
            ..:.          |.|..||    |:..|   |.:||.| :||.   ||.:....|:....|..
  Rat  1555 TSEADNILLAGHLRLIKTLLSLCGAEKEVL---GSSLIKPLLDDF---LFRASRIILNSHSPAGS 1613

  Fly   303 ASASPTMLGP----------GYDYGAPTGDSDVEGVTGVTDPSTIGTDDGTYPALSNFYRRKYGG 357
            |:.|.....|          .|:......||....:..:| ...:.......|||:..:
  Rat  1614 AAISQQDFHPKCSTVNSRLAAYEVLVMLADSSPSNLQIIT-KELLSMHHQPDPALTKEF------ 1671

  Fly   358 DELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRN 422
                          |::      ...::|..|    |:|||.|...|||:|::.|.|:|.|....
  Rat  1672 --------------DYL------PPVDSRSIS----GFVGLRNGGATCYMNAVFQQLYMQPGLPE 1712

  Fly   423 ALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFGWDSTEAW--QQHDIQELCRV 485
            :|...:.|.||...::.||:|.||.:|..|........:..:.|...:.|.:  :|.|..|....
  Rat  1713 SLLSVDDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTS 1777

  Fly   486 MFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIE 550
            :.|.::...|...:..:..|.::|..:|...|.:|.....||:.|:.:.|.|      ::..|:|
  Rat  1778 LIDQMDEYLKKMGREQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGV------TSCQSLE 1836

  Fly   551 EALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRV 615
            .:|..||:.|.|:|:|.|.|||||:|....|....||.|.:|.:||.||.||:::...||.::::
  Rat  1837 ISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQI 1901

  Fly   616 TFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLN- 679
            .||..||:..:                ||       :|.|.:|          :||...||..|
  Rat  1902 RFPWMLNMEPY----------------TV-------AGMARQD----------SSSEVGENGRNM 1933

  Fly   680 DEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKD---FDNNEWFCFNDQNV 741
            |:..|   .|...|.|...:    |||..:::|||.|..||||::|||   ....:|:.|||
  Rat  1934 DQGGG---GSPRKKVALTEN----YELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFND--- 1988

  Fly   742 TSITQEDIQ------RSFGGPNGSYYSSAYTSST----------NAYMLMYRQVDAKRNELVAK- 789
            |.|.:.|:.      ..||   |.|....|..:.          |||||.|::|..:.:.::.|
  Rat  1989 TVIEEFDLNDETLEYECFG---GEYRPKVYDQTNPYPDVRRRYWNAYMLFYQRVSDQNSPVLPKK 2050

  Fly   790 ----------------VADFPEHIKTLLPKLHSEEETRVSRLGRHITVTDL--ALPDLYKPRVY- 835
                            ....||......|:.|.....|:|.|.:.:...:.  ...:....|:|
  Rat  2051 SRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQ 2115

  Fly   836 -FYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFA-PLSRCRL-VAYNSSMDTIIQS--- 894
             ..:.:||.||...||.|..|:..|.|.|    ||..:.. |...|.. |:...::..:.|:
  Rat  2116 MVRDENLKFMKNRDVYSSDYFSFVLSLAS----LNATKLKHPHYPCMAKVSLQLAVQFLFQTYLR 2176

  Fly   895 ----LESCTDPALTELRAAQNYSLD---FLLEY--RAEDQEF-EVY------------------- 930
                |...|:..:..:.|..:.|||   :|:||  .:|.:|. :|:
  Rat  2177 TKKKLRVDTEEWIATIEALLSKSLDACQWLVEYFISSEGRELVKVFLLECSVREVRVAVATILEK 2241

  Fly   931 PPNGITWY---------VFKVDLSTMAMDGP---------FLVYSAARERE---ASDVLRRSIAL 974
            ..:...:|         :.:|.|:.:..|.|         |.:::...:::   |.|:|.|..||
  Rat  2242 TLDSALFYQDKLKSLHQLLEVLLALLDKDVPENCKNCAQYFSLFNTFVQKQGIRAGDLLLRHSAL 2306

  Fly   975 RLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYFYLNVPNTDAATLEM 1039
            |..||   |||...:..                 ..::..::.|.:.    :.|:.||.|    :
  Rat  2307 RHMIS---FLLGVSQQN-----------------SQIRRWSSAQARE----FGNLHNTVA----L 2343

  Fly  1040 LGVPTVESVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGHESNSED 1104
            |.:.|             |.:....||||.........        |.|.|...|.  ||.....
  Rat  2344 LVLHT-------------DVSSQRNVAPGIFKQRPPIS--------VAPSSPLLPL--HEEVEAL 2385

  Fly  1105 SSLSDGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMMRVHAY---CNGNGSYA 1166
            ..||:|...|:|.                     :.:..:...|..|:|.:..|   ||.:.|:.
  Rat  2386 LFLSEGKPYLLEV---------------------MFALRELTGSLLALMEMVVYCCFCNEHFSFT 2429

  Fly  1167 AADVVDPLLLPTSTNHFFYAT--------------KVECVDVV-----GTGSSSGHQSDEEAQLR 1212
            ....:.. .|.|:..|....|              :||.|..|     |..:...|.:..::
  Rat  2430 MLHFIKN-QLETAPPHELKNTFQLLHEILVMEDPIQVERVKFVFETENGLLALMHHSNHVDS--- 2490

  Fly  1213 KPTRAY---KLLVGTHMRMGAFKKHIEQLIQVPAAHFK-----LQRKHDNNLSNNQNNSLVHLIE 1269
              :|.|   |.||....:..|.|::.::    .:.|:.     ||:|...:....|:|     :.
  Rat  2491 --SRCYQCVKFLVTLAQKCPAAKEYFKE----NSHHWSWAVQWLQKKMSEHYWTPQSN-----VS 2544

  Fly  1270 GETLTVELGKTLE 1282
            .||.|   |||.:
  Rat  2545 NETST---GKTFQ 2554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188	35/180 (19%)
		Rib_recp_KP_reg	122..265	CDD:282899	41/222 (18%)
		peptidase_C19C	394..780	CDD:239124	121/407 (30%)
		UCH	395..776	CDD:278850	119/402 (30%)
Usp24	NP_001258135.1	UBA_UBP24	6..42	CDD:270472
		peptidase_C19C	1684..2041	CDD:239124	122/408 (30%)
		UCH	1686..2036	CDD:278850	119/401 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810