DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp47 and Usp18

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	NP_001014080.1	Gene:	Usp18 / 312688	RGDID:	1359153	Length:	362	Species:	Rattus norvegicus

Alignment Length:	431	Identity:	113/431 - (26%)
Similarity:	174/431 - (40%)	Gaps:	106/431 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 NFYRRKYGGDEL-RAWQRVNTTGADFVSSATTETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQ 412
            |..|::....|| .||.|                          |.|:|||.|...||.||||:|
  Rat    30 NMKRKRVLSRELCSAWDR--------------------------PHGFVGLHNIGQTCCLNSLIQ 68

  Fly   413 ALFMTPEFRNALYRWEFDN--DNEAKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFGWDSTEAWQ 475
            ...|..:||..|.|.....  :.:.:::|:||..|...:|.|.:.||..|:|.:.....:...:.
  Rat    69 VFMMNVDFRMVLKRITVPRGAEEQKRSVPFQLLLLLEKMQDSRQKAVLPTELVQCLQKYNVPLFV 133

  Fly   476 QHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPF 540
            |||...|...:::..:.:..:...|..:.:|:.....:.:.|:.|..|.:|....|.:.||:...
  Rat   134 QHDAAHLFLTIWNLTKDQITDIDLAERLQDLFTIWTEESLMCVGCGAESSRRGKLLTLSLPLFDM 198

  Fly   541 GSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQT 605
             .|....::|:|||.|.||:.|..:::..||.|.||....:......||..||:||.|  |..:.
  Rat   199 -DSKPLKTLEDALRCFFQPKELASSDKCFCETCGKKTPCKQAQKLTGFPQTLTIHLMR--FSVRN 260

  Fly   606 MHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTAS 670
            ...:|:...|.|||:|:.              ||:                        :.||..
  Rat   261 SQTVKICHSVYFPQSLDF--------------SQI------------------------LPTTDQ 287

  Fly   671 SSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKDFDNNEWFC 735
            |..|                             |||||::.|.|.|..|||.|||::..:.||||
  Rat   288 SEIH-----------------------------YELFAVIAHVGMADFGHYCAYIRNPVDGEWFC 323

  Fly   736 FNDQNVTSITQEDIQRSFGGPNGSYYSSAYTSSTNAYMLMY 776
            |||.:|..:|.:|:|.::|       ...|.....||:|:|
  Rat   324 FNDSHVCWVTWKDVQCTYG-------DHIYRWRETAYLLVY 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	105/385 (27%)
		UCH	395..776	CDD:278850	103/382 (27%)
Usp18	NP_001014080.1	UCH	52..357	CDD:278850	103/381 (27%)
Usp18	NP_001014080.1	Peptidase_C19	53..358	CDD:239072	103/382 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910