DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and ubp5

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	NP_588211.1	Gene:	ubp5 / 2539385	PomBaseID:	SPCC188.08c	Length:	1108	Species:	Schizosaccharomyces pombe

Alignment Length:	1099	Identity:	253/1099 - (23%)
Similarity:	404/1099 - (36%)	Gaps:	339/1099 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 WQRVNTTGADFVSSATTETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRW 427
            |...|    |:.|...|              |||||.||..|||:|||||:|::...||..:|:.
pombe   198 WHSFN----DYDSKIAT--------------GYVGLKNQGATCYMNSLLQSLYIIHAFRRIVYQI 244

  Fly   428 EFDNDNEAKNIPYQLQKLFLNLQ--TSPKAAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDAL 490
            ..|:.....:|.|.||:.|.|||  ..|   |.||:||:||||||.:::.|||:||..||:.|.|
pombe   245 PTDSPQGKDSIAYALQRCFYNLQFMNEP---VSTTELTKSFGWDSLDSFMQHDVQEFNRVLQDNL 306

  Fly   491 EHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRA 555
            |...::||..|.::||:.|||..|:.|:..|.|..|.:.:.||.|.|:      ...::|::.|:
pombe   307 ERSMRDTKVENALTNLFVGKMKSYIACVNVNFESARSEDYWDIQLNVK------GMKNLEDSFRS 365

  Fly   556 FVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQT 620
            ::|.|||:|:|.|..:....: :|.||:.|:|||.||.|.||||::|::....||:|||..||..
pombe   366 YIQVETLEGDNCYFADTYGFQ-EAKKGVIFESFPPILHLQLKRFEYDFERDMMIKINDRYEFPLE 429

  Fly   621 LNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGI 685
            .:...|::...:..:          :|.
pombe   430 FDAKAFLSPEADQSQ----------NCE------------------------------------- 447

  Fly   686 DMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKDFDNNEWFCFNDQNVTSIT-QEDI 749
                              |.|:.:::|||....|||||.:|...:..|:.::|..||..| :|.:
pombe   448 ------------------YVLYGVLVHSGDLHNGHYYALLKTEKDGPWYKYDDTRVTRATLREVL 494

  Fly   750 QRSFGGPNGSYYSSAYTSS-------TNAYMLMYRQVDAKRNELVAKVA--DFPEHIKTLL-PKL 804
            :.::|   |.|.......|       .:||||:|.:.| |.:||:..|:  :.|||:|..| |.:
pombe   495 EENYG---GDYIMHPPFRSPVKLKRFMSAYMLLYLRKD-KLDELMNPVSADEIPEHLKEALNPSI 555

  Fly   805 HSEEETRVSRLGRHI-TVTDLALPDLYKPRVYF----YNPSLKKMKITRVYVSQSFNINLVLMSA 864
            ...|..|..||..|: |...|..|:.|.....|    :..:.|:..|.:..:.:....:..:...
pombe   556 QLAELRRKERLESHLYTKVQLITPEFYSEHHEFDIADFGNAYKEETIPQFRIKKEAKFSEFIPIV 620

  Fly   865 YEMLNVEQFAPLSRCRLVAYNSSMDTIIQSLESCT----------DPALTELRAAQNYSLDFLLE 919
            .|.|...|     .|....|       :....:||          :..:.|::...|...:.|..
pombe   621 AEKLGYPQ-----ECMRFWY-------VVKRHNCTVRVESPVNELNSTMEEVKNVWNSQGEILRL 673

  Fly   920 YRAEDQEFEVYPPNGIT----------WYVFKVDLSTMAMDGPFLVYSAAREREASDVLRRSIAL 974
            |      .|:.|.|.::          |..|           .|:.|...:.:|.|.      ..
pombe   674 Y------LEITPENELSSSLTHQNTGEWNAF-----------IFVKYFDRKSQEISG------CG 715

  Fly   975 RLHISEQQFL-----LATVRATVPK--------------------------------AFVSYDPH 1002
            .||:::...:     |...||.:||                                ..:.::|
pombe   716 TLHVNKSDEIRSICPLLCERANLPKNTPLNIYEEIKPGMVDFLRLEKTFTQSELSTGDIICFEP- 779

  Fly  1003 PTPEALQHLQNMANTQFKSITYFYLNVPNT----------------------------DAATLEM 1039
            ..|.||:  .::.|:.|.|....|..:.|.                            |...:|:
pombe   780 CRPSALE--DDIVNSGFDSALKLYDFLSNKVLVLFRPRFIDQDSIIEFEMLLDRRIKYDDLCIEL 842

  Fly  1040 ---LGVPTVESVECASGGDVVDAAMMNGVA-PGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGHES 1100
               ||:          |.|.:.....|.:. ...|...||.:...|  :::....:..||:....
pombe   843 GQKLGI----------GADHIRLTTCNPLTYSAGMVVPNDSNITLY--EILYSSEEEMPSNVIFY 895

  Fly  1101 NSEDSSLSDGDR-TLVE----TDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMMRVHAYCN 1160
            .:.|.||||.|| .||.    .|.:|:                             :..|.||.|
pombe   896 ETMDVSLSDLDRKRLVRLRWLVDGLAN-----------------------------IELVEAYIN 931

  Fly  1161 GNGSYAAADVVDPLLLPTSTNHF----FYATKVECVDVVGTGSSSGHQSDEEAQLRKPTRAYKLL 1221
            .:|     |:.|  |.......|    ....||...:|.   .|..|:......|.:.......|
pombe   932 KSG-----DIND--LFGAVCERFPDSDLRKKKVRVYEVF---ESRYHRDLSLRTLIRTINPAATL 986

  Fly  1222 VGTHMRMGAFKKHIEQ-LIQVPAAHFKLQRKHDNNLSNNQNNSLVHLIEGETLTVE-----LGKT 1280
            ||..:.:...:.:.|: ::||...|..:.|.|....|        .:|:.:...::     ..:|
pombe   987 VGEVVPLDQLQLYPEEKIVQVHHFHKDIARIHGIPFS--------FVIKPQEKFIDTKLRLAART 1043

  Fly  1281 LEPDEFKAKIHFLRLADIDNE--------------TSKLPCVCEWVYNANTTAEQAKKE 1325
            ..|:...:.|.|. :.|.||.              ..||        |.....::|||:
pombe  1044 QYPESIFSVIKFC-VVDFDNNRVVYLNDEDITYDVVEKL--------NGTLALDRAKKD 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	126/395 (32%)
		UCH	395..776	CDD:278850	124/390 (32%)
ubp5	NP_588211.1	COG5077	15..1107	CDD:227409	253/1099 (23%)
		MATH_Ubp21p	56..188	CDD:239744
		peptidase_C19C	211..530	CDD:239124	127/397 (32%)
		USP7_ICP0_bdg	631..881	CDD:289221	43/294 (15%)
		USP7_C2	892..1092	CDD:291217	48/255 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810