DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and Usp40

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	NP_001185502.1	Gene:	Usp40 / 227334	MGIID:	2443184	Length:	1235	Species:	Mus musculus

Alignment Length:	1392	Identity:	290/1392 - (20%)
Similarity:	470/1392 - (33%)	Gaps:	423/1392 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 PRGYV---GLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDN----------DNEAKNIPYQLQ 443
            ||.:.   |:.||..||||:||||.|..|||||.||:....:.          |.:.:.||.|||
Mouse    34 PREFTNLSGIRNQGGTCYLSSLLQTLHFTPEFREALFSLGPEELGSLEDKDKPDAKVRIIPLQLQ 98

  Fly   444 KLFLNLQTSPKAAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYE 508
            :||..|....:.|..|.|||.||||.:.|..:|||:|||.|::|.|||.....|...:||..||.
Mouse    99 RLFAQLLLLDQEAASTIDLTDSFGWTNDEEMRQHDVQELNRILFSALETSLVGTSGHDLIHRLYH 163

  Fly   509 GKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKC 573
            |.:.:.:.|.||.....|::.|||:.:.|:     :..|..:|....:|:.|..|.:|.|.|..|
Mouse   164 GTIVNQIVCKECKNISERQEDFLDLTVAVK-----NVSGLEDELCNMYVEEEIFDYDNLYHCGTC 223

  Fly   574 KKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNS 638
            .:...|.|....:..|..||:.|.||:||:....|.|.....|||..:||..|..:|
Mouse   224 DRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKDTSCYTFPLRINLKPFCEQS-------- 280

  Fly   639 QLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYL 703
                                                  :|:|.:                   |:
Mouse   281 --------------------------------------ELDDME-------------------YM 288

  Fly   704 YELFAIMIHSGSASGGHYYAYIKDFDN-NEWFC---FNDQNV-------------------TSIT 745
            |:||:::||.|...||||:.||||.|: ..|.|   .:|.||                   |.:.
Mouse   289 YDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQCQEEISDTNVNVKAPQSEEEANDPLVVLKTILL 353

  Fly   746 QEDIQRSFGGPNGSYYSSAYTSSTNAYMLMYRQVDAKRNELVAKVADFPEHIKTLLPKLHSEEET 810
            ||:..:.   |...........:..::...||    |::..:.|.......|..|     |.:|:
Mouse   354 QEEANQI---PVDQLGQKLLKKTGISWNKKYR----KQHGPLRKFLQLHPQIFLL-----STDES 406

  Fly   811 RVSRLGRHITVT-----------------------DLALP---DLYKPRVY-------------- 835
            .||.|..|:|..                       |.:.|   |:...:|:
Mouse   407 TVSLLRNHLTQAPSDLQSCEQILHTLASESPGLNDDTSCPHWFDINDSKVHPIREKDITQQFQGK 471

  Fly   836 ------FY-------------NPS-------LKKMKITRVYV----------SQSFNINLVLMSA 864
                  ||             ||.       ||:|....:.:          :.:|.::|.|...
Mouse   472 ESAYMLFYRKATLQRPPEARANPRYRVPCHLLKEMDAANILLQMRRAECDSANSTFELHLHLGPH 536

  Fly   865 YEMLNVEQFAPLSRCRLVAYNSSMDTIIQSLESCTD------PALTELRAAQNYSLDFLLEYRAE 923
            |..                :|.::...:...||..|      ..|.:||    .|:..|||....
Mouse   537 YRF----------------FNGALHPAVSETESVWDLTFDKRKTLGDLR----QSIFQLLECWEG 581

  Fly   924 DQEFEVYP--PNGITWYVFKVDLSTMAMDGPFLVYSAAREREASDVLRRSIALRLHISEQQFLLA 986
            |....|..  |.|:..|        ..:||..|....|...:..|:               |:..
Mouse   582 DMVLSVAKRVPAGLHVY--------HTLDGDDLTLCEAEVADGEDI---------------FVWN 623

  Fly   987 TVRATVPKAFVSYDPHPTPEALQHLQ-----NMANTQFKSITYFYLNVPNTDAATLEMLGVPTVE 1046
            .|.....:....:|..|....:.||:     :......:|...|..|.  ...|....||.|
Mouse   624 GVEVGGVQIQTGFDCEPLLLNILHLELSGEGSKCEQLVESPHVFPANA--EVGAVFTALGTP--- 683

  Fly  1047 SVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRY-KRDLVEPMSQPSPSHG-----HESNSEDS 1105
                      ..|.:||.|     .|::...|... |.|:.:...:....:|     .:|:|:::
Mouse   684 ----------AGAILMNSV-----ESADGECWTAVPKEDMKKTFREQGLRNGSLILVQDSDSDNN 733

  Fly  1106 SL---------SDGDRTLVETDNMAHRGGGDSQV--SSTSHSP----QLSSPED-----EAASHD 1150
            ||         |..:...::..|.......:.||  :.|.|:.    ::.:.::     |.|.:.
Mouse   734 SLLPKQGRWTNSMNELNWLQVKNFCQSESEEKQVQIAVTMHTVVFDIRIKAIKELKLMKELAENS 798

  Fly  1151 AMMRVHAYCNGNGSYAAADVVDPLLLPTSTNHFFYATKVECVDVVGTGSSSGHQSDEEAQL---R 1212
            .:..:    :.||.         ||.|...:......:|:      .|||.|        |   :
Mouse   799 CLRPI----DRNGK---------LLCPVPDSSTLEEAEVK------MGSSVG--------LCLGK 836

  Fly  1213 KPTRAYKLL---VGTHMRMGA-FKKHIEQLIQV-PAAHFKLQRKHDNNLSNNQNNSLVHLIE--- 1269
            .||.:...|   :||.:..|| ....:|:.:.| ......|::       :.|...:.||.:
Mouse   837 APTSSQLFLFFALGTDIHPGAEMDIIVEETLSVRDCLKIMLEK-------SGQQGEIWHLRKMDW 894

  Fly  1270 ----------------------GETLTVELGKTLEPDEFKAKIHFL------------------- 1293
                                  |:||.:..||...|...|..|.:.
Mouse   895 CYEAGEPLCEEDATLKELMIRSGDTLLLTEGKLPPPGHLKMPIWWYQPARLSGHCESRDHLNCAF 959

  Fly  1294 ------RLADIDNETSKLPCVCEWVY------NANTTAEQAKKELVAKLHRIDAKYATLSVQNCR 1346
                  |.|.........|.....:|      :...|..:.|.:.:| |..: :|.|..|....|
Mouse   960 SQDSTWRAAPTQGAPGPEPAEVSLLYLGDMEISEEATLVELKSQALA-LPSV-SKLAVQSTALLR 1022

  Fly  1347 IWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPKDDSLTLFVRRWCPAKLEFGK 1411
            :|....:.|.::|..:.....:.|....||..::..::|.|..|:|..|...:|  .|.:..:..
Mouse  1023 VWTVESKRPSRLLRTNWRQLKEYRLGRRAELCLELLQKEEDLGPRDVLLRTQLR--IPGERAYSL 1085

  Fly  1412 FQEITLDQD-----SEIRLSLSQISDIPIDKLSYMKLNSNFPCTSISALSVNESSSW-YSVPTTL 1470
            ..::..|..     ..:|..::....:|::|:...|.   || .....|.:   ||| ..|....
Mouse  1086 ATDLIWDTTRGWTAGSLRQRVADFYSLPVEKIEIAKY---FP-EKFEWLPI---SSWNQQVAKRK 1143

  Fly  1471 DKYPLNSTQTGNIYLYKDRTVPARELTLEERRLMNAREKARLDRVGCVSTTRYAQRRERALKIY- 1534
            .|...::.|.|..||....|:..:.|..::    |.......|.:|..:..|.|..::::.:::
Mouse  1144 KKKNQDTLQGGPYYLKDGDTIGIKNLLFDD----NDDFSTIRDDIGKENQKRLALEKKKSREVHR 1204

  Fly  1535 LDSPEKSSNVTA-------SAPMDVHV 1554
            ..|.:..||...       .|.:.:||
Mouse  1205 AQSSDLFSNAGVPARFRGPEASLSIHV 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	120/421 (29%)
		UCH	395..776	CDD:278850	118/416 (28%)
Usp40	NP_001185502.1	peptidase_C19C	39..342	CDD:239124	114/372 (31%)
Usp40	NP_001185502.1	UCH	42..340	CDD:278850	114/367 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910