DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp47 and Usp34

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	XP_006514628.1	Gene:	Usp34 / 17847	MGIID:	109473	Length:	3583	Species:	Mus musculus

Alignment Length:	807	Identity:	171/807 - (21%)
Similarity:	291/807 - (36%)	Gaps:	206/807 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 ETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQK 444
            :..||.|        :|||.|...||||.|.:|.|:|.||.|.|::..::..|.:.|....:|||
Mouse  1924 DVRAECR--------FVGLTNLGATCYLASTIQQLYMIPEARQAVFTAKYSEDMKHKTTLLELQK 1980

  Fly   445 LFLNLQTSPKAAVETTDLTRSFGWDS--TEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLY 507
            :|..|..|...|.......:::..|.  ....:|.|:.|....:...:|......|  |.:.:|:
Mouse  1981 MFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLITKVEEMSPELK--NTVKSLF 2043

  Fly   508 EGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEK 572
            .|.:.:.|..|:|.......:.|..:...|...  .:.|.|::|.    ...:||:|:|.|.|..
Mouse  2044 GGVITNNVVSLDCEHVSQTAEEFYTVRCQVADM--KNIYESLDEV----TIKDTLEGDNMYTCSH 2102

  Fly   573 CKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQN 637
            |.||..|.|...||..|.||:.:..|:.|:..||.:.|:|...:||..|::..:
Mouse  2103 CGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPY----------- 2156

  Fly   638 SQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPY 702
                              .||..:..               :|..||.......||..:.    |
Mouse  2157 ------------------TEDFLMGK---------------SDRKEGFKDVGDRSKDTES----Y 2184

  Fly   703 LYELFAIMIHSGSASGGHYYAYIKD------FDNNEWFCFNDQNVTSITQEDI-QRSFGGP---- 756
            .|:|..:.:|:|:|.|||||::|:|      :.||:|:.|||..|.......: ...|||.
Mouse  2185 EYDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLASECFGGEMTTK 2249

  Fly   757 -----NGSYYSSAYTSSTNAYMLMYRQVDAKR-----------NELVAKVADFPEHIKTLLPKLH 805
                 ...:...::..:.:||||.|::::.:.           :||:..:  :.::::.|..| :
Mouse  2250 TYDSVTDKFMDFSFEKTHSAYMLFYKRMEPEEENGREYKFDVSSELLEWI--WHDNMQFLQDK-N 2311

  Fly   806 SEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNV 870
            ..|.|....:.:..:.....|||   |:..    ||...|::..:|.::|
Mouse  2312 IFEHTYFGFMWQLCSCIPSTLPD---PKAV----SLMTAKLSTSFVLETF--------------- 2354

  Fly   871 EQFAPLSRCRLVAYNSSMDTIIQSLESCTDPALTELRAAQNYSLDFLLEYRAED----QEFEVYP 931
                        .::....|::|.:|     .||:.......:.::.|:..|:|    .:..:..
Mouse  2355 ------------IHSKEKPTMLQWIE-----LLTKQFNNSQAACEWFLDRMADDDWWPMQILIKC 2402

  Fly   932 PNGITWYVFK----------------VDLSTMAMDGPFLVYSAAREREASDVLRRSIALRLHISE 980
            ||.|...:|:                :.|.....||     |...:....|:..||...|.   .
Mouse  2403 PNQIVRQMFQRLCIHVIQRLRPVHAHLYLQPGMEDG-----SDDMDASVEDIGGRSCVTRF---V 2459

  Fly   981 QQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMA-----NTQF-------KSITYFYLNVPNTD 1033
            :..||.......|     :..|.| |....|...|     .:||       .::.:||:.....:
Mouse  2460 RTLLLIMEHGVKP-----HSKHLT-EYFAFLYEFAKMGEEESQFLLSLQAISTMVHFYMGTKGPE 2518

  Fly  1034 AATLEMLGVPTVESVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGH 1098
            ...:|:|.....|..|  ...|::..|.                 .:|:...:|.|.........
Mouse  2519 NPQVEVLSEEEGEEEE--EEEDILSLAE-----------------EKYRPAALEKMIALVALLVE 2564

  Fly  1099 ESNSEDSSLSDGDRTLVETDNMAHRGG 1125
            :|.||      ...||.:||..|..||
Mouse  2565 QSRSE------RHLTLSQTDMAALTGG 2585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	102/403 (25%)
		UCH	395..776	CDD:278850	101/398 (25%)
Usp34	XP_006514628.1	peptidase_C19C	1930..2279	CDD:239124	103/412 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910