DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and K02C4.3

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	NP_001309441.1	Gene:	K02C4.3 / 174300	WormBaseID:	WBGene00010502	Length:	1261	Species:	Caenorhabditis elegans

Alignment Length:	1369	Identity:	269/1369 - (19%)
Similarity:	440/1369 - (32%)	Gaps:	494/1369 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 VAKKTAKVTSKPTLELLSPIKPSSPIKELDCEPVDTLSKQQLSEQLQLYPQGRNLISPVDDAPSD 285
            :|.|.|:.      |:|..|:     |..:|:|.|        ||.            :.|..::
Worm    39 IADKVAEA------EILESIR-----KRSECKPTD--------EQF------------ISDIINE 72

  Fly   286 LFISDAEQLSDDDLALGASASPTMLGPGYDYGAPTGDSDVEGVTGVTDPSTIGTDDGTYPALSNF 350
            ||.|....        ....|...:||.:|   |...|...|....||   :.:.|.|:|.:|
Worm    73 LFYSGEPP--------KGRKSERFIGPLFD---PEKASTASGPMDCTD---VVSYDSTHPNIS-- 121

  Fly   351 YRRKYGGDELRAWQRVNTTGADFVSSATTETEAEARQASL---------GPRGYVGLVNQAMTCY 406
                    |:...:.|....|...|.|::.::..:|...|         .|....||.|...||:
Worm   122 --------EISKKEEVEMQSAIQQSLASSASQNISRPTMLMSNLEDMVRNPNFSTGLYNSGNTCW 178

  Fly   407 LNSLLQALFMTPEFRNALYR-----WEFDNDNEAKNIPYQLQK----------LFLNLQTSPKAA 456
            ||.|.|.|:..|:||:.||.     |   ::....|:..:.|:          ||..||.|....
Worm   179 LNCLSQVLYSIPKFRSILYHCAPLSW---HEQPITNVKIENQQHAELLMLFRGLFAELQFSEMKY 240

  Fly   457 VE-------TTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANL---ISNLYEGKM 511
            :|       ...|::|....||...|| |..|:..::||.|:..|.....|.|   .||:.:
Worm   241 IEVGPLINMVDKLSKSSKGPSTIGTQQ-DATEMLTLIFDWLQRAFDAALHAQLNPEFSNVSD--- 301

  Fly   512 NDYVKCLECNTEKTREDTF----------LDIP-----------------------LPVRPFGSS 543
            .:.:...:..|.....|..          |.:|                       .|...||:.
Worm   302 EENLVISDSTTTAPNSDIIGAPPGYNAANLSLPSSSHVDPKSTLNPMYVNEKEPSSTPTSLFGTR 366

  Fly   544 SAYGSIEEALRAF------------------VQPETLDGNNQYLCEKCK---------------- 574
            |....:.|::...                  ..|| :|.|.:..|:|.|
Worm   367 SKTIEVNESMDTEAATSSNLPGNSVENHPNPAAPE-VDDNKKAFCDKLKESFNNIFSSVCYTESV 430

  Fly   575 ------------KKC-----------DAHKGLHFKSF------------------PYILTLHLKR 598
                        :.|           :.|..|...:|                  |.::...|.|
Worm   431 AEDGTVSVKSNVRNCPQFFQLQVTYGNLHDALEAATFDHGLGNTASHVRNLYDPLPAVIFFGLSR 495

  Fly   599 FDFDYQTMHRIKLNDRVTFPQTLNLNTFIN-----------------------RSGNSG-EQNSQ 639
            |.|:...  ..||:|:.|||:.:.::.::.                       |:..|| .:..|
Worm   496 FSFNSNI--ESKLHDKFTFPKIIFMDRYLKCNKEQLVQLRSHRELCRDSLSEVRAKLSGLRRYPQ 558

  Fly   640 LNGTV---DDCSTA--------DSGSAMED----------------DNLSSGVV----------- 666
            .||.|   |...|.        |...|.|:                ||.||..|
Worm   559 GNGEVRLEDSFQTVWQAVSNFRDREDAHENTAFVGPLTPSTYQSSSDNCSSKFVKDGGKLFPTFT 623

  Fly   667 -----------------TTASSSQHENDLNDE---DEGIDMSSSTSKSAKQGSGPYLYELFAIMI 711
                             ..|..::..:.|.:|   .|.||.:....:..:     :.|||.||::
Worm   624 EGFFPGKAAFIETLQNMLEALKTEERDCLAEEARLQEVIDQTYEVPELQQ-----HKYELHAIIV 683

  Fly   712 HSGSASGGHYYAY--IKDFDN-NEWFCFNDQNVTSITQEDIQR-SFGGPNGSYYSSAYTSSTNAY 772
            |||.|:.|||:.|  .|..|. .||...||||...:....::. |||  .||      ..:.:||
Worm   684 HSGEANRGHYWTYKLKKSIDGLEEWEKLNDQNADRVDWPKVESDSFG--TGS------RDAPSAY 740

  Fly   773 MLMYRQVDA----------------------------KRNELVAKVADFPEH-------IKTLLP 802
            ||||.:.||                            ||:|...|:..|.|:       .....|
Worm   741 MLMYVRSDAEWLVSADKLTALEAFETIPPDLQEKVLQKRDEFKEKLQRFRENKEFNYQQFSVDSP 805

  Fly   803 KLHSEEETRVSRLGRHITVTDLALPD----------LYKPRVYFYN----PSLKKMKITRVYVSQ 853
            .:.|.|||..|.......:.|:.:.|          |...|:..|:    |.::..::.|: |||
Worm   806 TVQSTEETPSSFSWYRDELEDIDIGDENANPTKNDYLLNARLDSYSVPIAPDVETSEMKRM-VSQ 869

  Fly   854 SFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDTIIQSLESCTD---PALTELRAAQNYSLD 915
            .:|            .:.:.||..      |..|.|.:..:|.|..:   ..:..:.:...|.:.
Worm   870 MWN------------QITKIAPRK------YTDSQDLLDSNLRSVMEGESGGINFINSRLGYDIH 916

  Fly   916 FLLEYRAE-DQEFE-VYPPNG-ITWYVFKV-DLSTMAMDGPFLVYSAAREREASDVLRRSIALRL 976
               |.|:: |.:.| ||  |. |..|:..| ||..: .:..|:|:...:.:            |:
Worm   917 ---ELRSDADNDVEGVY--NAFINEYLGLVKDLHEL-QNSKFVVFVGFQLQ------------RI 963

  Fly   977 HISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNM-ANTQFKS---------ITYFY----- 1026
            |:...::||....|......:|      ..|...|..| :|:..|.         :::|:
Worm   964 HVPVLRYLLVRAMAVSELGIIS------QRANNELSGMSSNSHDKGTAMLQIALLLSHFFELGVM 1022

  Fly  1027 -----------LNVPNTDAATLEMLGVPTVESVECASGGDVVDAAMMNG---------------- 1064
                       ::|...|.......|...:|...||..| ..:|.:.||
Worm  1023 SAWGCRSSLENIHVILNDFKKKNSRGSEQIEVTYCAMIG-ARNARICNGLLREMAYFLESYSIFF 1086

  Fly  1065 VAPGHMSSSNDYDWRRYKRDLVEPMS----QPSPSHGHESNSEDS-SLSDGDRTLVETDNMAHRG 1124
            |:..|:.:...:......:.:::.|:    |......|.|.:|.. ...|..|.:|.:..:.|..
Worm  1087 VSQKHIEACTVFSTITMIKLIMQHMASKTLQLIDMEFHLSKNERRVRFEDIIREVVSSVCIIHHW 1151

  Fly  1125 GGDSQVSSTSHSPQLSSPEDEAASHDAMMRVHAYCNGNGSYAAADVVDPLLLPTSTNHFFYATKV 1189
                   |.|:|.:.   ::|....:.|..:|.......|..:.:|.||              |.
Worm  1152 -------SKSYSKEF---QNEINLKELMGLLHLKVEFMVSLTSFEVADP--------------KY 1192

  Fly  1190 ECVD-----VVGTGSSSGHQSDE--------EAQLRKPTRAYKLLVGTHMRMG----AFKKHIEQ 1237
            ||:.     ||.|.......|:|        ..:||:..:.:|.|..|.:::.    ::...||.
Worm  1193 ECLQAFKAMVVNTVMDLERASNELDYDVLDGAVELRELKKYFKELQLTDVKVNNIITSYDPIIES 1257

  Fly  1238 LIQV 1241
            |:::
Worm  1258 LVKI 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188	3/12 (25%)
		Rib_recp_KP_reg	122..265	CDD:282899	10/43 (23%)
		peptidase_C19C	394..780	CDD:239124	126/604 (21%)
		UCH	395..776	CDD:278850	124/599 (21%)
K02C4.3	NP_001309441.1	UCH	168..744	CDD:278850	124/598 (21%)
		Peptidase_C19I	169..745	CDD:239130	125/598 (21%)
		Peptidase_C19	169..>299	CDD:271592	39/133 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900