DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and usp24

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	XP_002931653.2	Gene:	usp24 / 100497137	XenbaseID:	XB-GENE-6035156	Length:	2577	Species:	Xenopus tropicalis

Alignment Length:	1440	Identity:	294/1440 - (20%)
Similarity:	506/1440 - (35%)	Gaps:	459/1440 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SEQKKINVVVRSHFTVKRVIDLIGTQFSYEKFELLLQPHDNKDLVNLNALESQLMY-------EV 77
            |..::::|..||...|:.:|...         .:.:|..:..|.....|...:|.:       ::
Frog  1255 SSYRQLSVSDRSSIRVEEIIPAA---------RVAIQTMEVNDFTCTVACFMRLSWAAAAGRLDL 1310

  Fly    78 AGFEPQLKNHLILLPSGSWDGDVTKRFELPIKRVVVKKVMKSDGEKAKSPATGE----------- 131
            .|....:|....|.|:|                  ::..:.|.|....|.:.||
Frog  1311 VGSNQPIKESNTLFPAG------------------LRSRLSSSGSNCSSGSEGESTSLHAWICVR 1357

  Fly   132 ------KKKRVVGEKTK--------KKPASGS--SSPSKAKTTSEDSLAKTSISSESSPEKTSKI 180
                  |...:.||...        :....||  :.||.|..|.:..|...|          ::|
Frog  1358 QQSVSTKDAIIAGEALSLLVTCLQLRSQQLGSFYNLPSVADFTIDILLGSPS----------AEI 1412

  Fly   181 KTTAAKISKPGSEKAPRASPEECPELSTEINSKNTSSESPVAKKTAKVTSKPTLELLSPI----- 240
            :..|                  |.:|.| ::..:|||...|        .||.|.||:.|
Frog  1413 RRVA------------------CDQLYT-LSQTDTSSYPEV--------QKPNLFLLTVILSAQL 1450

  Fly   241 ---KPSSPIK--------------ELDCEPVDTLSKQQLSEQLQLYPQGR-------------NL 275
               .|:|.::              :|.|:.:|.|:..:: |||.:.|...             |.
Frog  1451 PLWSPTSIMRGINQRLLAQCTEYFDLRCQLLDDLTCSEM-EQLNVSPATMLEDEITWLDNFEPNR 1514

  Fly   276 ISPVDDAPSD-LFISDAEQLSDDDLALGASASPTMLGPGY------DY-----------GAPTGD 322
            .:..:.:.:| ::::...:|....|:| ..|...||||..      |:           .:|.|.
Frog  1515 TAECETSEADNVWLAGHLRLIKTLLSL-CGAEKEMLGPSLIKQLLDDFLFRASRIILNSHSPAGS 1578

  Fly   323 SDVEGVTGVTDPSTIGTDDGTYPALSNFYRRKYGGDELRAWQRVN---------TTGADFVSSAT 378
            :.:.........||:.:....|..|...........:|...:.::         |...|::....
Frog  1579 AAISQQDFHPKCSTMNSRLAAYEVLVMLAESSLANLQLITKELLSMHHQPDPAVTKEFDYLPPVD 1643

  Fly   379 TETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQ 443
            :.:.:          |:|||.|...|||:|::.|.|:|.|....||...|.|.||..:::.||:|
Frog  1644 SRSNS----------GFVGLKNGGATCYMNAVFQQLYMQPGLPEALLSMEGDTDNPDESVFYQVQ 1698

  Fly   444 KLFLNLQTSPKAAVETTDLTRSFGWDSTEAW-------QQHDIQELCRVMFDALEHKFKNTKQAN 501
            .||.:|..|.....    :..:| |...:.|       :|.|..|....:.|.::...|...:..
Frog  1699 SLFGHLMESKLQYY----IPENF-WKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGREQ 1758

  Fly   502 LISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNN 566
            :..|.::|..:|...|.:|.....||:.|:.:.|.|      ::..|:|.:|..||:.|.|:|:|
Frog  1759 IFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGV------TSCQSLEISLDQFVRGEILEGSN 1817

  Fly   567 QYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSG 631
            .|.|||||.|....|....||.|.:|.:||.||.||:::...||.::::.||..||:..:
Frog  1818 AYYCEKCKDKRTTVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIKFPWMLNMEPY----- 1877

  Fly   632 NSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAK 696
                       ||       :|.|.:|.:..:|          ||..:.:..|   .|...|.|.
Frog  1878 -----------TV-------AGMARQDSSCEAG----------ENGRHIDPGG---GSPRKKVAP 1911

  Fly   697 QGSGPYLYELFAIMIHSGSASGGHYYAYIKD---FDNNEWFCFNDQNVT--SITQEDIQ-RSFGG 755
            ..:    |||..:::|||.|..||||::|||   ....:|:.|||..|.  .:..|.|: ..||
Frog  1912 TEN----YELVGVIVHSGQAHAGHYYSFIKDRRGSGKGKWYKFNDTVVEEFDLNDETIEYECFG- 1971

  Fly   756 PNGSYYSSAYTSST----------NAYMLMYRQVDAKRNELVAK-----------------VADF 793
              |.|....|..|.          |||||.|::|..:.:.::.|                 ....
Frog  1972 --GEYRPKVYDQSNPYPDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSS 2034

  Fly   794 PEHIKTLLPKLHSEEE-----TRVSRLG--RHITVTDLALPDLYKPRVY--FYNPSLKKMKITRV 849
            |:......|:.|...:     |::.|.|  :.:.|..:.|      |:|  ..:.:||.||...|
Frog  2035 PDISPQSSPRPHRPNDRLSILTKLVRKGEKKGLFVEKIPL------RIYQTVRDENLKFMKNRDV 2093

  Fly   850 YVSQSFNINLVLMSA-YEMLNVEQFAPLS----------------------RCRLVAYNSSMDTI 891
            |.|..|:..|.|.|. ...|....:.|::                      |.....:.:::|.:
Frog  2094 YNSDYFSFVLSLASVNATKLKHPLYQPMAKVSAQLAIQFLFHTYLRTKRKLRVDTEEWIATIDAL 2158

  Fly   892 I-QSLESC--------------------TDPALTELRAAQNYSLDFLLEYRAEDQEFEVYPPNGI 935
            : :|.|:|                    .:.::.|:|||    :..:||...:...|.....||:
Frog  2159 VSKSCEACQWLMEYFVCSEGKELVKIFLLESSIREVRAA----VATILEKTLDAALFHGDKVNGV 2219

  Fly   936 TWYVFKVDLSTMAMDGP---------FLVYSAAREREAS---DVLRRSIALRLHIS--------- 979
             ..:.::.||.:..|.|         |.::|...:::.|   |:|.|..||:..|:
Frog  2220 -HLLIEMLLSLLEKDVPESCKNCAQYFYLFSNFVQKQGSRAVDLLLRYSALKHFINFLLGPNRQN 2283

  Fly   980 ------------EQQFLLATVRATVPKAFVS---------YDPHPT------------------- 1004
                        |..:|.:|:...|..:.||         :.|||:
Frog  2284 NQNRRWSSPQAREFGYLHSTIALLVLYSDVSSHRTVAPGVFKPHPSTNTCGSPLLLHAEVEALMF 2348

  Fly  1005 -PE----------ALQHLQN-------------MANTQFK-SITYFYLN---------VPNTDAA 1035
             ||          ||:.|..             ..|.:|. ::.:|..|         :.|....
Frog  2349 MPEGKPYLLEVMFALRELPGSLTVLIEMVVYCCFCNERFSLTLLHFIKNQLETAPPHELKNVFTL 2413

  Fly  1036 TLEMLGVP---TVESVECASGGDVVDAAMMNGVAPGHMSSS------------------------ 1073
            ..|:|.:.   .::.::.....|.:.|.|.:.   .|:.||
Frog  2414 LYEILVIEDPLQLQRLKFTFESDGLLALMHHS---NHVDSSRCYQCVKFLVTLAQKCPAAKEYFK 2475

  Fly  1074 -NDYDWRRYKRDLVEPMSQPSPSHGHESNSEDSSLSDGDRTLVETDNMAHRGG--GDSQVSSTSH 1135
             |.:.|....:.|.:.||:...:.....::|.|:.....||:...|.:|:...  .:...|.:|:
Frog  2476 DNSHHWSWAVQWLQKKMSEHCWAPQSNISNETSTAKTFQRTVSAQDTLAYATALLNEKDQSGSSN 2540

  Fly  1136 SPQLSSPEDE 1145
            ..: |||.:|
Frog  2541 GSE-SSPANE 2549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188	27/141 (19%)
		Rib_recp_KP_reg	122..265	CDD:282899	35/191 (18%)
		peptidase_C19C	394..780	CDD:239124	122/408 (30%)
		UCH	395..776	CDD:278850	120/403 (30%)
usp24	XP_002931653.2	UBA_UBP24	6..42	CDD:270472
		Ubl_UBP24	917..995	CDD:340585
		peptidase_C19C	1649..2005	CDD:239124	123/409 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910