DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp47 and usp9x

DIOPT Version :9

Sequence 1:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster
Sequence 2:	NP_001123721.2	Gene:	usp9x / 100170466	XenbaseID:	XB-GENE-1010834	Length:	2548	Species:	Xenopus tropicalis

Alignment Length:	1011	Identity:	220/1011 - (21%)
Similarity:	351/1011 - (34%)	Gaps:	350/1011 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LQPHDNKDLVNLNAL--------ESQLMYEVAG--FEPQLKN--------HLILLPSGSWDGDVT 101
            |.|.||..:..|.|:        ||.|...:..  |.|....        :.:|:|:.:..|:..
Frog  1050 LMPPDNTIVEKLRAICLDHAKLGESSLSSSLDSLFFGPSASQVLYLTEVVYALLMPANAPLGEDA 1114

  Fly   102 KRFE--------LPIKRVVVKK---VMKSDGEKAKS-------------PATGEKKKRVVGEKTK 142
            ..|:        ||:...::.:   :..:|.|..:|             .|.|....|.|.|..
Frog  1115 SDFQYNFLKSGGLPLILSMLTRNNFLPNADMETRRSAYLNALKVAKLLLTAIGYGHVRAVAEAC- 1178

  Fly   143 KKPASGSSSPSKAKTTSEDSLAKTSISSESSPEKTSKIKTTAAKISKPGSEKAPRASPEEC---- 203
             :|....::|..|.|..:..:.:.::.:..:|.....::..|.::::..|::|.:..|:.|
Frog  1179 -QPVVEGTNPVSAATHDQAVVLQNALQNIPNPTSECMLRNVAIRLAQQISDEASKYIPDICVIRA 1242

  Fly   204 --------------------PELSTEINSKNTSSESP-----------VAKKTAKVTSKPT-LEL 236
                                .|:| :|..|..:...|           :...|......|| ||.
Frog  1243 IQKIIWASGCGSVQLVFSANEEIS-KIYEKTNAGNEPDPEDEQVCCEALEAMTLCFALIPTALEA 1306

  Fly   237 LSPIKPSSPIKE-----------LDCEPVDTLSKQQLSEQLQL---------------------- 268
            ||        ||           |.|:  ..|.:|...||..|
Frog  1307 LS--------KEKAWQTFIIDLLLHCQ--SKLVRQMAQEQFFLMATRCCMGHRPLIFFITLLFTV 1361

  Fly   269 ---------------YPQGRNLISPVDDAPSDLFISDAEQLSDDDLALGASASPTMLGPGYDYGA 318
                           :...|:|::...:  |::.|.:||.|.::::        ..|....|...
Frog  1362 LGSTARERAKHAGDYFTLLRHLLNYAYN--SNINIPNAEVLLNNEI--------DWLKRIRDDVK 1416

  Fly   319 PTGDSDV-----EGVTGVT-------DPST---IG------------TDDGTYPALSNFYRRKYG 356
            .||::.:     ||..|||       .|..   ||            .||..:|| ||.|.:...
Frog  1417 RTGETGIEETILEGHLGVTKELLAFQTPEKKYHIGCEKGGASLIKELIDDFIFPA-SNVYLQYIK 1480

  Fly   357 GDELRAWQRV------NTTGADFV---------------------------SSATTETEAEARQA 388
            ..||.|.|.:      .|..|.|.                           ..|.||.|......
Frog  1481 SGELPAEQAIPVCSSPATINAGFELLVALAVGCVRNLRQIVDTLNDMYYTGCEALTEWEYLPPVG 1545

  Fly   389 SLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWE-----FDN--------DNEAK---- 436
            ...|:|:|||.|...|||:||::|.|:|.|..||.:...|     .|:        |||:.
Frog  1546 PRLPKGFVGLKNAGATCYMNSVIQQLYMIPAIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPR 1610

  Fly   437 ----NIPYQ-----------------------LQKLFLNLQTSPKAAVETTDLTRSFGWDSTEAW 474
                ..|:|                       ||.:|.:|..|.....    :.|.| |.....|
Frog  1611 DDVFGYPHQYDDKPSLSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYY----VPRGF-WKQFRLW 1670

  Fly   475 -------QQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLD 532
                   :|||..|....:.|:|:...|......::|.:..|...|...|..|......|::|..
Frog  1671 GEPVNLREQHDALEFFNSLVDSLDEALKALGHPTMLSKVLGGSFADQKICQGCPHRYECEESFTT 1735

  Fly   533 IPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLK 597
            :.:.:|      .:.::.:::..:|:.:.|:|.|.|.||||.||.|..|.|..|..|.:|.:.||
Frog  1736 LNVDIR------NHQNLLDSMEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLK 1794

  Fly   598 RFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLS 662
            |||:|::....||.||...||:.|::..:                      |....:.:|.|:::
Frog  1795 RFDYDWERECAIKFNDYFEFPRELDMEPY----------------------TVAGVAKLEGDDVN 1837

  Fly   663 SGVVTTASSSQHENDL--NDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYI 725
            .           ||.:  ||:.|.....||.            |.|..:::|||.|||||||:||
Frog  1838 P-----------ENQVIPNDQTENEPPVSSK------------YRLVGVLVHSGQASGGHYYSYI 1879

  Fly   726 -----KDFDNNEWFCFNDQNVTSITQEDIQ----RSFGGPNGSYYSSAYTSST------------ 769
                 .|.:.|.|:.|:|.:||....:|.:    :.||   |.|....:....
Frog  1880 IQRNGGDGEKNRWYKFDDGDVTECKMDDDEEMKNQCFG---GEYMGEVFDHMMKRMSYRRQKRWW 1941

  Fly   770 NAYMLMYRQVDA--KRNELVAKVADF-----PEHIK 798
            |||:|.|.::|.  |.||:|..:::.     |..||
Frog  1942 NAYILFYERMDTLDKDNEMVKYISELTITSKPHQIK 1977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188	26/163 (16%)
		Rib_recp_KP_reg	122..265	CDD:282899	35/202 (17%)
		peptidase_C19C	394..780	CDD:239124	118/459 (26%)
		UCH	395..776	CDD:278850	116/454 (26%)
usp9x	NP_001123721.2	Ubiquitin_like_fold	885..968	CDD:421700
		peptidase_C19C	1551..1953	CDD:239124	118/460 (26%)
		DUF3517	2092..2471	CDD:403300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000