Protein Alignment Usp47 and usp47

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_021333046.1
• Gene: usp47 / 100101645
• ZFINID: ZDB-GENE-070719-7
• Length: 1374
• Species: Danio rerio
• Alignment Length: 1450
• Identity: 491/1450 - (33%)
• Similarity: 711/1450 - (49%)
• Gaps: 261/1450 - (18%)

  Fly   238 SPIKPSSPIKELDCEPVDTLSKQQLSEQLQL--------------------YPQGRNLIS----- 277
            |.|:.::....:.|...||.:.:.::|:|.|                    |..|...:|
Zfish    34 SQIESAAEEPRVLCIVQDTTNAKTVNERLTLNLPASTTLSKFFEDVAHKAGYVNGTFCLSWANTG 98

  Fly   278 ---PVDDAPS-DLFISDAE-------QLSDDD-----LALGASASPTMLGPGYDYGAPTGDSDVE 326
               |:|.|.. .|.:|..|       ||:|.|     :|...||              |.||.
Zfish    99 DMAPLDQASEMSLVMSGFEAGKRNFLQLTDKDGEQPQIASDESA--------------TADSG-- 147

  Fly   327 GVTGVTDPST---IG--TDDGTYPALSNFYRRKYGGDELRAWQRVNTTGADFVSSATTETEAEAR 386
               |:.|.|.   ||  ..|||....|::....|.                 .||...::|.
Zfish   148 ---GLDDSSQDRFIGPLPRDGTVGCSSDYSSPSYS-----------------YSSILNKSET--- 189

  Fly   387 QASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNE--AKNIPYQLQKLFLNL 449
                   |||||||||||||||||||.||||||||||||.|||::..|  ..:||||||:||:.|
Zfish   190 -------GYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYNWEFEDSEEDPVTSIPYQLQRLFVLL 247

  Fly   450 QTSPKAAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDY 514
            |||.|.|:||||:||||||||:|||||||:||||||||||||.|:|.|:||:||:.||:||:.||
Zfish   248 QTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINQLYQGKLKDY 312

  Fly   515 VKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDA 579
            |:||||..|..|.||:|||||.:||||:|.|:||:||||:||:|||||||.|||.||:|||||||
Zfish   313 VRCLECGYESWRIDTYLDIPLVIRPFGASQAFGSVEEALQAFIQPETLDGPNQYFCERCKKKCDA 377

  Fly   580 HKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTV 644
            .|||.|..|||:|||.||||||||.||||||||||:|||:.|:::.||:.......|..
Zfish   378 RKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSPFIDVEDEKSPQTE------ 436

  Fly   645 DDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDE---DEGI--DMSSSTSKSAKQGSGPYLY 704
               |..|||:..|.         :..|.|..||.:.:   ||||  |.:||..:..|..|. ..:
Zfish   437 ---SCTDSGAENEG---------SCHSDQMSNDFSTDDGVDEGICLDNASSAERVLKPKSS-LTF 488

  Fly   705 ELFAIMIHSGSASGGHYYAYIKDFDNNEWFCFNDQNVTSITQEDIQRSFGGPNGS--YYSSAYTS 767
            |||::|:|||||:||||||.||.|.:::|:.||||:|:.|||:||::::||.:||  |||||:.|
Zfish   489 ELFSVMVHSGSAAGGHYYACIKSFSDSQWYSFNDQHVSKITQDDIRKTYGGSSGSRGYYSSAFAS 553

  Fly   768 STNAYMLMYRQVDAKRNELVAKVADFPEHIKTLL--PKLHSEEETRVSRLGRHITVTDLALPDLY 830
            ||||||||||..|..||....:|.|||||||.|:  .|...|:|.|...:.|:..
Zfish   554 STNAYMLMYRLKDPSRNAKFLEVEDFPEHIKRLVQREKESEEQEKRQREIERNTC---------- 608

  Fly   831 KPRVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDTIIQSL 895
            |.:::..:|....|...::.|.:...:|.....||:::::|...||..||||.|:...:.:.:|.
Zfish   609 KIKLFCMHPVKMMMMENKLEVHKDKTLNEATEMAYKLMDLEGVVPLDCCRLVKYDEFHEYLERSY 673

  Fly   896 ESCTDPALTELRAA--QNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSA 958
            |...|..:..|...  .:|..|.|||.|..:|.|:.|.|..:...|..|||.:.::..|..|.:
Zfish   674 EGEEDMPMGLLLGGVKSSYMFDLLLEIRRPEQAFQPYKPGEVMVKVHVVDLKSESIAAPVSVRA- 737

  Fly   959 AREREASDVLRRSIALRLHISEQQFLLA--------TVRATVPKAF----VSYDPHPTPEALQHL 1011
                          .|...|:|.:.|:|        |:|..:.:.:    :.|.|:.|.:
Zfish   738 --------------YLNQTITEFKQLIAQATGLCAETMRVVLERCYNDLRLLYVPNKTLK----- 783

  Fly  1012 QNMANTQFKSITYFYLNVPNTD--AATLEMLGVPTVESVECASGGDVVDAAMMNGVAPGHMS--- 1071
               |...|:|...|..:..:||  ||..:.:....::    ..|..:.....:...:||..:
Zfish   784 ---AEGFFRSNKVFVESSDSTDHQAAFTDSVLWKLLD----RHGNTIRLFVSLPEQSPGSFANRT 841

  Fly  1072 --------SSNDYDWRRYKRDLVEPMSQPSPS-------HGHESNSEDSSLSDGDRTLVETD--- 1118
                    |.:.:|..:..|..||.:.:.|..       ...:...:.||.||..::...:|
Zfish   842 SCPKASADSEDSFDGAKAGRKSVEAILEESTEKLKNLSLQQQQQQQQTSSTSDSQKSSEHSDFEH 906

  Fly  1119 --NMAHRGGGDSQVSSTSHSPQLSS------PEDE-------------AASHDAMMRVHA---YC 1159
              :.|......||.|.|.:..:.:|      |.:|             :...|.:...|:   .|
Zfish   907 IESPAQEPDASSQPSQTENCTRAASDTDNQFPSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLC 971

  Fly  1160 NG-NGSYAAADVVDPLLLPTSTNHFFYATKVECVDVVGTGSSSGHQSDEEAQLRKPTR------- 1216
            |. :|....|:.:|...:.:|.....:..|.|..|.....|.:..:.||..:.:..|:
Zfish   972 NADSGPLPLANGLDSHSITSSRRSKAHEGKKETWDTAEEDSGTDSEYDENGKSKADTQYLYFKAE 1036

  Fly  1217 -----------AYKLLVGTHMR--MGAFKKHIEQLIQVPAAHFKLQRKHDNNL---SNNQNNSLV 1265
                       ...|||....|  :.|||:::|..:.||:..||:.|.:.||.   |...|.:|.
Zfish  1037 PYSQEDGAGDGQKSLLVHVDKRITLAAFKQNLEPFVGVPSTQFKVFRVYANNQEFESVRLNETLS 1101

  Fly  1266 HLIEGETLTVELGKTLEPDEFKAKIHFLRLADIDNETSKLPC--VCEWVYNANTTAEQAKKELVA 1328
            ...:...:|:.||:.|:..|::.|::.|.:.|.:      ||  :.:.|:....|..|:|:||:.
Zfish  1102 FFSDDNKITIRLGRALKKGEYRVKVYQLLVNDPE------PCKFLLDTVFAKGMTVRQSKEELLP 1160

  Fly  1329 KLHRIDAKYATLSVQNCRIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPKDD 1393
            :|.  |.....||:...|:..|..:.|..:..|......|:..|...| :..|..||.:......
Zfish  1161 QLK--DQCKLDLSIDRFRLRKKTWKNPGTVFLDYHVYEEDINISSNLE-VFLEVLEEPERMKSMS 1222

  Fly  1394 SLTLFVRRWCPAKLEFGKFQEITLDQDS--EIRLSLSQISDIPIDKLSYMKLNSNFPCTSISALS 1456
            .|.:..||||||:::...|:|:.|:..|  |::..||::|.||::.|.:.|....||| .||.|.
Zfish  1223 QLAVLTRRWCPAQMKLEAFREVVLESSSVEELKEKLSEVSGIPLENLEFAKGRGTFPC-DISVLE 1286

  Fly  1457 VNESSSWYSVPTTLDKYPLNSTQTGNIYLYKDRTVPARELTLEERRLMNAREKARLDRVGCVSTT 1521
            :::...|....:||:.:||.....|.:..|:|.:....||:.|||..:..:|.:||.:.|  ...
Zfish  1287 IHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDSSEELMELSEEERNELMKKESSRLLKTG--HRV 1349

  Fly  1522 RYAQRRERALKIYLD-SPEK 1540
            .|:.|:|:||||||| .|.|
Zfish  1350 SYSPRKEKALKIYLDGGPTK 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066	2/10 (20%)
		peptidase_C19C	394..780	CDD:239124	242/394 (61%)
		USP47_C	1300..1534	CDD:466158	70/237 (30%)
usp47	XP_021333046.1	peptidase_C19C	190..567	CDD:239124	242/395 (61%)
		MSCRAMM_ClfA	<902..>1028	CDD:468110	23/125 (18%)
		USP47_C	1123..1362	CDD:466158	73/250 (29%)