DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sse and ESPL1

DIOPT Version :9

Sequence 1:	NP_523935.1	Gene:	Sse / 38640	FlyBaseID:	FBgn0035627	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_036423.4	Gene:	ESPL1 / 9700	HGNCID:	16856	Length:	2120	Species:	Homo sapiens

Alignment Length:	523	Identity:	117/523 - (22%)
Similarity:	204/523 - (39%)	Gaps:	87/523 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LTESAELENQRPTAEELIKSATKLEKKDYKSKKFLQNIIKYLQQMEQEKQP-KKPINEIPEYLDF 123
            :|||..:..:......|.:..:|.:|     .:....|...||.:..::.| ..|:..|.....|
Human  1620 VTESVSITCRHQLLTHLHRQLSKAQK-----HRGSLEIADQLQGLSLQEMPGDVPLARIQRLFSF 1679

  Fly   124 --LDDVQDPTEGLTRISEKCNSLPQ--EWCVLQLCKSFNPATTYSVFNEIIASDGAIYLTLLRHC 184
              |:....|........|:...:|.  ..|||.|. :..|              |.:..|||...
Human  1680 RALESGHFPQPEKESFQERLALIPSGVTVCVLALA-TLQP--------------GTVGNTLLLTR 1729

  Fly   185 RSSQLGPICLKI-SNENTANLFREYSTLVERFRRVVTVDPLNMKGKE-----AKQKYWEELNGFD 243
            ......|:.::| :.:|..:|    .:::..|      |.:....||     .|:::|......|
Human  1730 LEKDSPPVSVQIPTGQNKLHL----RSVLNEF------DAIQKAQKENSSCTDKREWWTGRLALD 1784

  Fly   244 TFQQKLLADF-RDIISPYSFLFFGKRYDCTVVQKQIKATYTRVDDFCLLNQWGTHQRVLLSQAAS 307
            ...:.|:|.. :.::..:..|......:....|:.     :|:.:......|....|.||....|
Human  1785 HRMEVLIASLEKSVLGCWKGLLLPSSEEPGPAQEA-----SRLQELLQDCGWKYPDRTLLKIMLS 1844

  Fly   308 HANRLEIADLKLICYELSSNENE-----IQSAYELLKGLASDWAEVEERQPLASRRFPIILVVDE 367
            .|..|...|::.:.|.|...:.|     :..|...|:||.         .|..|.   ::||:|:
Human  1845 GAGALTPQDIQALAYGLCPTQPERAQELLNEAVGRLQGLT---------VPSNSH---LVLVLDK 1897

  Fly   368 RLDHLHWEQLVTVQEF--SRVKSLHCLWRLFQNHKSNIKHGYYTTNIKRGM------CVINPDAD 424
            .|..|.||.:.::|..  :|:.|..     |....|.||....:..:.:|:      .|:||..:
Human  1898 DLQKLPWESMPSLQALPVTRLPSFR-----FLLSYSIIKEYGASPVLSQGVDPRSTFYVLNPHNN 1957

  Fly   425 LVNSGRRLRSFFEYWLSQ--WQHLFETVPNEEVMVKQALQADCFVYAGHGSGLQYVNGRIICRAR 487
            |.::..:.|:.|.   |:  |:.:...||..|.:.:...:.|.::|||||:|.::::|:.:.|..
Human  1958 LSSTEEQFRANFS---SEAGWRGVVGEVPRPEQVQEALTKHDLYIYAGHGAGARFLDGQAVLRLS 2019

  Fly   488 VRSVVFLFGCDSTRMLGTGLYSALYGAHDY--YHGALCPSIVGTLMPALDGNMDTVSVTILSRWL 550
            .|:|..||||.|..:...|   .|.||...  |..|.||..:|.|....|.::|..:..:|..||
Human  2020 CRAVALLFGCSSAALAVRG---NLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWL 2081

  Fly   551 APG 553
            ..|
Human  2082 GAG 2084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sse	NP_523935.1	Peptidase_C50	171..538	CDD:281555	90/390 (23%)
ESPL1	NP_036423.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1355
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1412..1485
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1507..1561
		Peptidase_C50	1721..2069	CDD:281555	89/385 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160153
Domainoid	1	1.000	67	1.000	Domainoid score	I9900
eggNOG	1	0.900	-	-		E1_COG5155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7216
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003217
OrthoInspector	1	1.000	-	-		oto90633
orthoMCL	1	0.900	-	-		OOG6_103054
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R264
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.620