DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sse and Espl1

DIOPT Version :9

Sequence 1:	NP_523935.1	Gene:	Sse / 38640	FlyBaseID:	FBgn0035627	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001014976.1	Gene:	Espl1 / 105988	MGIID:	2146156	Length:	2118	Species:	Mus musculus

Alignment Length:	511	Identity:	115/511 - (22%)
Similarity:	193/511 - (37%)	Gaps:	124/511 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 QQMEQEKQPKKPINEIPEYLDFLDDVQDPTEGLTRISEKCNSLPQEWCVLQLCKSFN-------P 159
            |..:.:||.:.|  |:.|:|..||           :.|:...:|  ...:|...||.       |
Mouse  1635 QLSKAQKQQESP--ELAEHLQRLD-----------LKERPGGVP--LARIQRLFSFKALGSGCFP 1684

  Fly   160 ATTYSVFNEIIA----------------SDGAIYLTLLRHCRSSQLGPICLKISNENTANLFREY 208
            ......|.|.:|                ..|.:..|||.........||.:||.   ||......
Mouse  1685 QAEKESFQERLALIPSGVTVCVLALATLQPGTLSNTLLLTRLEKDNPPITVKIP---TAQNKLPL 1746

  Fly   209 STLVERFRRVVTVDPLNMKGKE-----AKQKYWEELNGFD--------TFQQKLLADFRDIISPY 260
            |.:::.|      |.:....||     .|:.:|......|        ..::::|..:|.::.|.
Mouse  1747 SAVLKEF------DAIQKDQKENSSCTEKRVWWTGRLALDQRMEALITALEEQVLGCWRGLLLPC 1805

  Fly   261 SFLFFGKRYDCTVVQKQIKATYTRVDDFCLLNQ--WGTHQRVLLSQAASHANRLEIADLK-LICY 322
            |       .|.::.|:..|...       ||.:  |......||....|.|..|...|:: |.|.
Mouse  1806 S-------ADPSLAQEASKLQE-------LLRECGWEYPDSTLLKVILSGARILTSQDVQALACG 1856

  Fly   323 ELSSNENEIQSAYELLKGLASDWAEVEERQPLASRRFPIILVVDERLDHLHWEQ--LVTVQEFSR 385
            ...:..:..|..      |:....:|:.::  |.|...::||:|:.|..|.||.  ::..|..:|
Mouse  1857 LCPAQPDRAQVL------LSEAVGQVQSQE--APRSQHLVLVLDKDLQKLPWESTPILQAQPVTR 1913

  Fly   386 VKSLHCLWRLFQNHKSNIKHGYYTTNIKRG--------------MCVINPDADLVNSGRRLRSFF 436
            :.|...|..             ||...:.|              ..|:||.::|.::..|.|:.|
Mouse  1914 LPSFRFLLS-------------YTVTKEAGASSVLSQGVDPQNTFYVLNPHSNLSSTEERFRASF 1965

  Fly   437 EYWLSQ--WQHLFETVPNEEVMVKQALQADCFVYAGHGSGLQYVNGRIICRARVRSVVFLFGCDS 499
            .   |:  |:.:...||:.:.:.....:.|.::|||||:|.::::|:.:.|...|:|..||||.|
Mouse  1966 S---SETGWKGVIGEVPSLDQVQAALTERDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSS 2027

  Fly   500 TRMLGTGLYSALYGAHDY--YHGALCPSIVGTLMPALDGNMDTVSVTILSRWLAPG 553
            ..:   .::..|.||...  |..|.||..:|.|....|.::|..:..:|..||..|
Mouse  2028 AAL---AVHGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAG 2080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sse	NP_523935.1	Peptidase_C50	171..538	CDD:281555	93/418 (22%)
Espl1	NP_001014976.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1309..1352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1408..1428
		Peptidase_C50	1718..2065	CDD:397569	91/396 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850527
Domainoid	1	1.000	65	1.000	Domainoid score	I10031
eggNOG	1	0.900	-	-		E1_COG5155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7216
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003217
OrthoInspector	1	1.000	-	-		oto94222
orthoMCL	1	0.900	-	-		OOG6_103054
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R264
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.710