DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lin-28 and ybx1

DIOPT Version :9

Sequence 1:	NP_647983.1	Gene:	lin-28 / 38639	FlyBaseID:	FBgn0035626	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_571695.1	Gene:	ybx1 / 795398	ZFINID:	ZDB-GENE-000629-3	Length:	310	Species:	Danio rerio

Alignment Length:	138	Identity:	48/138 - (34%)
Similarity:	66/138 - (47%)	Gaps:	9/138 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 STSSANPANLASPTEECGCVRLGKCKWFNVAKGWGFLTPNDGGQEVFVHQSVIQMSG----FRSL 79
            |.||...|..|...:......||..|||||..|:||:..||..::|||||:.|:.:.    .||:
Zfish    19 SPSSPAAAATAGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSV 83

  Fly    80 GEQEEVEFECQRTSRGLEATRVSSRHGGSCQGSTY---RPRINRRTRRMRCYNCGEFANHIASEC 141
            |:.|.|||:.....:|.||..|:...|...|||.|   |.|..|..||.....  ::..:..|:.
Zfish    84 GDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRAPPR--DYQENYQSDP 146

  Fly   142 ALGPQPKR 149
            ...|:.||
Zfish   147 EAEPREKR 154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lin-28	NP_647983.1	CSP_CDS	41..101	CDD:239905	27/63 (43%)
ybx1	NP_571695.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		5/11 (45%)
		CSD	39..108	CDD:278729	29/68 (43%)
		C5-methylcytosine binding. /evidence=ECO:0000269\|PubMed:31399345, ECO:0007744\|PDB:6A6J	45..50		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..310		16/55 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586406
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000228
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740