DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lin-28 and YBX1

DIOPT Version :9

Sequence 1:	NP_647983.1	Gene:	lin-28 / 38639	FlyBaseID:	FBgn0035626	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_004550.2	Gene:	YBX1 / 4904	HGNCID:	8014	Length:	324	Species:	Homo sapiens

Alignment Length:	185	Identity:	57/185 - (30%)
Similarity:	77/185 - (41%)	Gaps:	44/185 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TSQSSTSSANPANLASPTEECGCVR------LGKCKWFNVAKGWGFLTPNDGGQEVFVHQSVIQM 73
            |:.|...|..|..|.|.....|..:      ||..|||||..|:||:..||..::|||||:.|:.
Human    29 TTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKK 93

  Fly    74 SG----FRSLGEQEEVEFECQRTSRGLEATRVSSRHGGSCQGSTYRPRINRRTRRMRCYNCGEFA 134
            :.    .||:|:.|.|||:.....:|.||..|:...|...|||.|....|...|
Human    94 NNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRR----------- 147

  Fly   135 NHIASECALGPQPKRCHRCRGEDHLHADCPHKNVTQSHSNSKSISNNSSSSAAQE 189
                       .|:|    ||        |.:|..|::.||:|...|..|.:|.|
Human   148 -----------YPRR----RG--------PPRNYQQNYQNSESGEKNEGSESAPE 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lin-28	NP_647983.1	CSP_CDS	41..101	CDD:239905	27/63 (43%)
YBX1	NP_004550.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		6/19 (32%)
		Interaction with ss-DNA. /evidence=ECO:0000269\|PubMed:11851341	15..71		14/41 (34%)
		CSD	59..128	CDD:278729	29/68 (43%)
		C5-methylcytosine binding. /evidence=ECO:0000269\|PubMed:31358969, ECO:0007744\|PDB:6A6L	65..70		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..324		24/94 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151844
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000228
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740