DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lin-28 and lin28b

DIOPT Version :9

Sequence 1:	NP_647983.1	Gene:	lin-28 / 38639	FlyBaseID:	FBgn0035626	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	XP_021324027.1	Gene:	lin28b / 103752590	ZFINID:	ZDB-GENE-140811-1	Length:	256	Species:	Danio rerio

Alignment Length:	189	Identity:	80/189 - (42%)
Similarity:	106/189 - (56%)	Gaps:	25/189 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SSTSSANPANLASPTEECGCVRLGKCKWFNVAKGWGFLT-------PNDGGQEVFVHQSVIQMSG 75
            |.|:...|.:|:..         |.||||||..|:||::       |.|...:||||||.:.|.|
Zfish    55 SDTARTPPQSLSGS---------GYCKWFNVRMGFGFISMTSSEGKPVDPPLDVFVHQSKLVMEG 110

  Fly    76 FRSLGEQEEVEFECQRTSRGLEATRVSSRHGGSCQGSTYRPR-----INRRTRRMRCYNCGEFAN 135
            ||||.|.|:|||..:|:|:|||:.||:...||.|.||..||:     :.|:.:..||||||...:
Zfish   111 FRSLREGEQVEFTFKRSSKGLESLRVTGPGGGPCSGSERRPKAKAPPLKRKPKGDRCYNCGGLDH 175

  Fly   136 HIASECALGPQPKRCHRCRGEDHLHADCPHKNVTQSHSNSKSISNNSSSSAAQEKSEEA 194
            | |.||.|.||||:||.|:...|:.|.||||.   :.|.|.|......|::||...||:
Zfish   176 H-AKECGLPPQPKKCHYCQSVTHMVAQCPHKG---APSPSASQDPQRPSTSAQSPEEES 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lin-28	NP_647983.1	CSP_CDS	41..101	CDD:239905	34/66 (52%)
lin28b	XP_021324027.1	CSP_CDS	69..137	CDD:239905	35/67 (52%)
lin28b	XP_021324027.1	AIR1	<157..209	CDD:331526	25/55 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586409
Domainoid	1	1.000	70	1.000	Domainoid score	I9487
eggNOG	1	0.900	-	-		E1_COG1278
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	140	1.000	Inparanoid score	I4481
OMA	1	1.010	-	-		QHG45847
OrthoDB	1	1.010	-	-		D1604809at2759
OrthoFinder	1	1.000	-	-		FOG0000228
OrthoInspector	1	1.000	-	-		otm25032
orthoMCL	1	0.900	-	-		OOG6_105612
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1972
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.670