DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and Prdm8

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	NP_084223.2	Gene:	Prdm8 / 77630	MGIID:	1924880	Length:	688	Species:	Mus musculus

Alignment Length:	980	Identity:	182/980 - (18%)
Similarity:	261/980 - (26%)	Gaps:	441/980 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 DVQAERGLPNRADKTLPRSLTLKSSMVYSTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYPN-- 169
            |...:||:.:...|.:.:.||...:.||:|.:           ||....|||.....||.|.:
Mouse     3 DSGIQRGIWDGDAKAVQQCLTDIFTSVYTTCD-----------IPENAIFGPCVLSHTSLYDSIA 56

  Fly   170 -------DKNKARYFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQSN-------WMRYVASAY 220
                   ||....|.:||                         |.|.:|       |:|.|.||.
Mouse    57 FVALKSTDKRTVPYIFRV-------------------------DTSAANGSSEGLMWLRLVQSAR 96

  Fly   221 SLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLGYDVDPETTIFGACKQAVEAEEE 285
            .....||.|......:::.:.|.|..:|||:|||.|:....|
Mouse    97 DKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELL----------------------- 138

  Fly   286 ADEEEEEAEGEDGKPRYSMPAPEIPPDVAVSHITYVMGLHLPVGAGNGPANGSVAGSVSGATPPP 350
                                                  |..|          |.|..::|::  |
Mouse   139 --------------------------------------LLCP----------SRAHKMNGSS--P 153

  Fly   351 PTATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHASVIIGQDRSP--MASSD---KDTAGSPLS 410
            .|...|.:|             .....|::.|.|.        |.|  :.|:|   :|..|..|.
Mouse   154 YTCLECSQR-------------FQFEFPYVAHLRF--------RCPKRLHSTDANPQDEQGGGLG 197

  Fly   411 GLDHQMTPQDGSVRSVRSDEGYHSNECHEDGLTPPEDSSDSESEHNYVLDCSKKAIAPKETVIAQ 475
            ..||      |.....:..:.....:..|..|.|......:...|:|
Mouse   198 TKDH------GGGGGGKEQQQQQQQQQQEAPLIPGPKFCKAGPIHHY------------------ 238

  Fly   476 AQKPSSSPPAVVMANTTTNSMISHSSPTATPICETDKNEYRKFKVKMPLKYEFKNKTCVKQEPSL 540
               |:|||.|              |:|..:....:.|
Mouse   239 ---PASSPEA--------------SNPPGSAGAGSAK---------------------------- 258

  Fly   541 KEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHLGDEHMLMMERERERERERIQEREPSNQQPAS 605
                                       |||     |.|.|              .||..|.:.:|
Mouse   259 ---------------------------PST-----DFHNL--------------ARELENSRGSS 277

  Fly   606 STVIVLEHNSGGQARTIVPLSKPYYEPDP------PGERYMRFGQPSSSILETILTSQHRLEAAA 664
            |.|......|||.......||     ||.      .|:|  ||.:.:::            |...
Mouse   278 SCVAAPGVGSGGSGHQEAELS-----PDGVATGGCKGKR--RFPEEAAA------------EGGG 323

  Fly   665 AAANACRQANAATPPPTSPTEM---------AYSYKKSQRYGNAVSPDSSSNLGQNPE--QLSSS 718
            |.....|...:..|..||..|:         |.||...:..|...:|.|       ||  :...|
Mouse   324 AGLAGGRARFSERPLATSKEELVCTPQQYRAAGSYFGLEENGRLFAPPS-------PETGEAKRS 381

  Fly   719 AVV--------VGEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEAGGHS-----P 770
            |.|        ||.||...||...|..:..|.:                 |.|.|||.|     |
Mouse   382 AFVEVKKAGRAVGLQEEAAATDGAGGTAEDPDA-----------------GGGVAGGGSNGSSTP 429

  Fly   771 SPGYPGYPHY------GAAATSTFHSPPHSSHSPFDRQSNASSGAGSAT---------------- 813
            :.|.||.|..      |.:..........:..|.|...|....|.|:.|
Mouse   430 AAGSPGAPEKLLAPRPGGSLPGRLEGGSPARGSAFTSVSQLGGGGGAGTAGTAGGSGGGQTAASD 494

  Fly   814 ---------NLHLLQTSTQMLNHPL--MQPLTPLQRLSPLRISP----PSSLSPDG-----NSC- 857
                     .....|.|..:|...|  ::|..|...:.|.|:.|    |.::...|     .:|
Mouse   495 ERKSAFSQPARSFSQLSPLVLGQKLGALEPCHPGDGVGPTRLYPAAADPLAVKLQGAADLNGACG 559

  Fly   858 -----------------------PRSGSPLSPNSLASRG----------------YRSLPYPLKK 883
                                   |:|.:..:..:.|:.|                :.||..|.:.
Mouse   560 PLASGGGGGLPKQSPFLYATAFWPKSSAAAAAAAAAAAGPLQLQLPSALTLLPPSFTSLCLPAQN 624

  Fly   884 KDGKMHYECNVCCKTFGQLSNLKVHLRTH-------------SGERPFKCNVCTKSFTQLAHLQK 935
                   .|..|..:|...|:|..|:|:|             ..|...||.:|.:||.:..||.:
Mouse   625 -------WCAKCNASFRMTSDLVYHMRSHHKKEYAMEPLVKRRREEKLKCPICNESFRERHHLSR 682

  Fly   936 HHLVH 940
            |...|
Mouse   683 HMTSH 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	36/142 (25%)
		C2H2 Zn finger	892..912	CDD:275368	7/19 (37%)
		zf-H2C2_2	904..929	CDD:290200	10/37 (27%)
		C2H2 Zn finger	920..940	CDD:275368	7/19 (37%)
		zf-H2C2_2	932..957	CDD:290200	4/9 (44%)
		C2H2 Zn finger	948..968	CDD:275368
		zf-H2C2_2	960..985	CDD:290200
		C2H2 Zn finger	976..996	CDD:275368
		C2H2 Zn finger	1004..1023	CDD:275368
Prdm8	NP_084223.2	PR-SET_PRDM8	6..138	CDD:380969	41/167 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..309		39/244 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..506		23/125 (18%)
		C2H2 Zn finger	626..646	CDD:275368	7/19 (37%)
		zf-C2H2	666..687	CDD:333835	8/20 (40%)
		C2H2 Zn finger	667..687	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810