DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and prdm8

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	NP_001039151.1	Gene:	prdm8 / 733976	XenbaseID:	XB-GENE-984391	Length:	589	Species:	Xenopus tropicalis

Alignment Length:	896	Identity:	157/896 - (17%)
Similarity:	244/896 - (27%)	Gaps:	401/896 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 KTLPRSLTLKSSMVYSTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYPN---------DKNKAR 175
            |.:.:.||...:.||:|.:           ||....|||.....||.|.:         ||....
Frog    19 KAVQQCLTDIFTSVYTTCD-----------IPENAIFGPCVLSHTSLYDSIAFIALKSTDKRTVP 72

  Fly   176 YFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQSN-------WMRYVASAYSLSVMNLVACQHQ 233
            |.:||                         |.|.:|       |:|.|.||.:....||.|....
Frog    73 YIFRV-------------------------DTSAANGSSEGLMWLRLVQSARNKEEQNLEAYIKN 112

  Fly   234 ENIYFYTTRDILPNEELMVWYCKDFASRLGYDVDPETTIFGA---------CKQAVEAE------ 283
            ..:::.:.|.:..:|||:|||.|:....|.......|.:...         |.|..:.|
Frog   113 GQLFYRSLRRVAKDEELLVWYGKELTDLLLLSPTSRTPVKNTVSSQSICLECNQKFQFEFPFVAH 177

  Fly   284 ----------------EEADEEEEEAEGEDGKPRYSMPAPEIPPDVAVSHITYVMGLHLPVGAGN 332
                            |.|.::..|.|     ||.:|.|     ....:.:|:    :.|....:
Frog   178 VRFRCPKRLQGSDSNLEHASKDNRELE-----PRNTMSA-----SAKYNKLTF----YQPQKENH 228

  Fly   333 GPANG---------SVAGSVSGATPPPPTATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHA-- 386
            .|...         :|.||.|..:..|..|.  ..|..|.   ||......|...:.::...:
Frog   229 KPTTDFHNLARDMENVRGSSSSFSSLPNKAN--LTRQDPD---STPDGLHRAKRKYDENQEESRS 288

  Fly   387 --SVIIGQ--DRSPMASSDKDTAGSPLSGLDHQMTPQDGSVRSVRSDEGYHSNECHEDGLTPPED 447
              |.:.|:  || |:.||.:|...||               :..|:...|:..|..:  |..|..
Frog   289 KKSDVSGRFLDR-PIPSSKEDLVCSP---------------QPFRTSSYYNLEESGQ--LFAPPS 335

  Fly   448 SSDSESEHNYVLDCSKKAIAPKETVIAQAQKPSSSPPAVVMANTTTNSMISHSSPTATPICETDK 512
            ....|::.:..::..|.:...::   ..|:..|.||              |||:..:.|
Frog   336 PETGEAKRSAFVEVKKTSRGVED---LNAEHKSMSP--------------SHSNSPSEP------ 377

  Fly   513 NEYRKFKVKMPLKYEFKNKTCVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHLGDE 577
               ::.:|:                            |:.:..::         .|.|:......
Frog   378 ---KRLQVR----------------------------PENQAGER---------SPITSAFSSVP 402

  Fly   578 HMLMMERERERERERIQEREPSNQQPASSTVIVLEHNSGGQARTIVPLSKPYYEPDPPGERYMRF 642
            .|..:|          |||:.:..||..|.   ..|.|
Frog   403 QMTNLE----------QERKSAFSQPTRSG---FNHIS--------------------------- 427

  Fly   643 GQPSSSILETILTSQHRLEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSN 707
              |...:.:.|::|...|:        |...|..|                   .....||..|.
Frog   428 --PLQVMGQKIISSGINLD--------CPGENVGT-------------------ARLFQPDPLSV 463

  Fly   708 LGQNPEQLSSSAVVVGEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEAGGHSPSP 772
            ..|:||                   |.|.|:                          ..|..|
Frog   464 KLQSPE-------------------INGNCT--------------------------LQGSLP-- 481

  Fly   773 GYPGYPHYGAAATSTFHSPPHSSHSPFDRQSNASSGAGSATNLHLLQTSTQMLNHPLMQPLTPLQ 837
                                  ..|||                 |..|:           ..|..
Frog   482 ----------------------KQSPF-----------------LFATT-----------FWPKS 496

  Fly   838 RLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQL 902
            ...||::..||:|:            |.|.|     :.||..|.:.       .|..|..:|...
Frog   497 SAGPLQLQMPSTLT------------LLPPS-----FTSLCLPAQN-------WCAKCNASFRMT 537

  Fly   903 SNLKVHLRTH-------------SGERPFKCNVCTKSFTQLAHLQKHHLVH 940
            |:|..|:|:|             ..|...||.:|.:||.:..||.:|...|
Frog   538 SDLVYHMRSHHKKEYAMEPLVKRRREEKLKCPICNESFRERHHLSRHMTSH 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	35/142 (25%)
		C2H2 Zn finger	892..912	CDD:275368	7/19 (37%)
		zf-H2C2_2	904..929	CDD:290200	10/37 (27%)
		C2H2 Zn finger	920..940	CDD:275368	7/19 (37%)
		zf-H2C2_2	932..957	CDD:290200	4/9 (44%)
		C2H2 Zn finger	948..968	CDD:275368
		zf-H2C2_2	960..985	CDD:290200
		C2H2 Zn finger	976..996	CDD:275368
		C2H2 Zn finger	1004..1023	CDD:275368
prdm8	NP_001039151.1	PR-SET_PRDM8	10..141	CDD:380969	38/157 (24%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	567..588	CDD:333835	8/20 (40%)
		C2H2 Zn finger	568..588	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910